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| 1 | Percutaneous coronary intervention in nonagenarians: pros and cons显示文摘Percutaneous coronary intervention is a mainstay in the management of symptomatic or high-risk coronary artery disease. The bulk of clinical evidence and experience underlying this fact relies, however, on relatively young patients. Indeed, few data of very limited quality are available which adequately define the risk-benefit and cost-benefit profile of coronary angioplasty and stenting in very old subjects, such as those of 90 years of age or older (i.e., nonagenarians). The aim of this review is to provide a concise, yet practical, synthesis of the available evidence on percutaneous coronary revascularization in the very elderly. The main arguments elaborated upon are to what extent we can extrapolate findings from studies including younger patients to nonagenarians, whether we should provide higher priority to prognosis or quality of life in such patients, and whether we can afford to allocate vast resources to care for such subjects in an era of financial constraints. Our review of 18 studies and 1082 patients suggest that percutaneous coronary intervention is feasible and associated with acceptable short- and long-term results in this population, which is nonetheless fraught with a high mortality risk irrespective of the revascularization procedure. Accordingly, the pros and cons of percutaneous coronary intervention should be carefully weighed when considering this treatment in nonagenarians. | Giuseppe Biondi Zoccai Antonio Abbate Fabrizio D'Ascenzo Davide Presutti Mariangela Peruzzi Elena Cavarretta Antonino G.M. Marullo Marzia Lotrionte Giacomo Frati | 2013 | Journal of Geriatric Cardiology2013，10，1： | 6 |
| 2 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 3 | The IGF-1 receptor in can-cer biology显示文摘 | Baserga R Peruzzi F Reiss K | 2003 | Int J Cancer2003，107，6： | 1 |
| 4 | Hyponatremia in acute spinal cord inj ury显示文摘 | Peruzzi WT Shapiro BA Meyer PR Jr et al | 1994 | Crit Care Med1994，22，2： | 1 |
| 5 | MicroRNAs in cancer: biomarkers, functions and therapy显示文摘 | Hayes J Peruzzi PP Lawler S | 2014 | Trends Mol Med2014，20，8： | 1 |
| 6 | New Insights into the Steen Solution Properties: Breakthrough in Antioxidant Effects via NOX2 Downregulation 显示文摘 | Carnevale R Biondi-Zoccai G Peruzzi M | 2014 | Oxide Med Cell Longev2014，2180，： | 1 |
| 7 | Changes in soil organic matter associated with pig rearing: Influence of stocking densities and land gradient on forest soils in central Italy显示文摘 | BONDI G PERUZZI E MACCI C | 2015 | Agriculture Ecosystems and Environment2015，211，： | 1 |
| 8 | Hyponatremia in acute spinal cord injury显示文摘 | Peruzzi WT Shapiro BA Meyer PR Jr | 1994 | Crit Care Med1994，22，2： | 1 |
| 9 | Gliomas and seizures 显示文摘 | Prakash O Lukiw WJ Peruzzi F | 2012 | Med Hypoth-eses2012，79，5： | 1 |
| 10 | MicroRNAs in cancer:biomark- ers,functions and therapy 显示文摘 | Hayes J Peruzzi PP Lawler S | 2014 | Trends Mol Med2014，20，： | 1 |
| 11 | MMPll: a novel target antigen for cancer immunotherapy显示文摘 | Peruzzi D Moil F Conforti A | 2009 | Clin Can- cer Res2009，15，12： | 1 |
| 12 | The IGF - 1 receptor in cancer biology显示文摘 | BASERGA R PERUZZI F REISS K | 2003 | Int J Cancer2003，107，： | 1 |
| 13 | Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy显示文摘 | Dharmawardana P G Peruzzi B Giubellino A Burke T R Jr Bottaro D P | 2006 | Anticancer Drugs2006，17，： | 1 |
| 14 | Ityponatremia in a-cute spinal cord injury 显示文摘 | PERUZZI W T SHAPIRO B A MEYER P R JR | 1994 | Crit Care Med1994，22，2： | 1 |
| 15 | The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo显示文摘 | Peruzzi B Araten DJ Notaro R Luzzatto L | 2010 | Mutat Res2010，705，1： | 1 |
| 16 | Cardiovascular and respiratory reflexes from muscles during dynamic and static exercise显示文摘 | Tallarida G Baldoni F Peruzzi G | 1981 | J Appl Physiol1981，50，4： | 1 |
| 17 | MicroRNAs in cancer:biomarkers,functions and therapy显示文摘 | HAYES J PERUZZI PP LAWLER S | 2014 | Trends Mol Med2014，20，8： | 1 |
| 18 | Presence and role of nitric oxide in the central nervous system of the freshwater snail Planorbarius comeus : possible implication in neuron microglia communication 显示文摘 | Elisa Peruzzi Giovanna Fontana Dario Souetti | 2004 | Brain Res2004，，1005： | 1 |
| 19 | IgACE:a placebocontrolled,randomized trial of angiotensin-converting enzyme inhibitors in ehildren and young people with IgA nephropathy and moderate proteinuria显示文摘 | Coppo R Peruzzi L Amore A | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 20 | Treatment of IgA nephropathy with angiotensin converting enzyme inhibitors: design of a prospective randomized muhicenter trial显示文摘 | Coppo R Chiesa M Peruzzi ct al | 2001 | J Nephrol2001，14，6： | 1 |
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