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| 1 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 2 | Gastric partitioning for the treatment of malignant gastric outlet obstruction显示文摘BACKGROUND Gastric outlet obstruction(GOO)is one of the main complications in stage IV gastric cancer patients.This condition is usually managed by gastrojejunostomy(GJ).However,gastric partitioning(GP)has been described as an alternative to overcoming possible drawbacks of GJ,such as delayed gastric emptying and tumor bleeding.AIM To compare the outcomes of patients who underwent GP and GJ for malignant GOO.METHODS We retrospectively analyzed 60 patients who underwent palliative gastric bypass for unresectable distal gastric cancer with GOO from 2009 to 2018.Baseline clinicopathological characteristics including age,nutritional status,body mass index,and performance status were evaluated.Obstructive symptoms were graded according to GOO score(GOOS).Surgical outcomes evaluated included duration of the procedure,surgical complications,mortality,and length of hospital stay.Acceptance of oral diet after the procedure,weight gain,and overall survival were the long-term outcomes evaluated.RESULTS GP was performed in 30 patients and conventional GJ in the other 30 patients.The mean follow-up was 9.2 mo.Forty-nine(81.6%)patients died during that period.All variables were similar between groups,with the exception of worse performance status in GP patients.The mean operative time was higher in the GP group(161.2 vs 85.2 min,P<0.001).There were no differences in postoperative complications and surgical mortality between groups.The median overall survival was 7 and 8.4 mo for the GP and GJ groups,respectively(P=0.610).The oral acceptance of soft solids(GOOS 2)and low residue or full diet(GOOS 3)were reached by 28(93.3%)GP patients and 22(75.9%)GJ patients(P=0.080).Multivariate analysis demonstrated that GOOS 2 and GOOS 3 were the main prognostic factors for survival(hazard ratio:8.90,95%confidence interval:3.38-23.43,P<0.001).CONCLUSION GP is a safe and effective procedure to treat GOO.Compared to GJ,it provides similar surgical outcomes with a trend to better solid diet acceptance by patients. | Marcus Fernando Kodama Pertille Ramos Leandro Cardoso Barchi Rodrigo Jose de Oliveira Marina Alessandra Pereira Donato Roberto Mucerino Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 2 |
| 3 | Soy protein concentrate and isolated soy protein similarly lower blood serum cholesterol but differently affect thyroid hormones in hamsters显示文摘 | Potter SM Pertile J Berber-Jimenez MD | 1996 | J Nutr1996，126，8： | 1 |
| 4 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 5 | Mechanisms involved in the antinociception caused by melatonin in mice显示文摘 | Mantovani M Kaster MP Pertile R et a1 | 2006 | J Pineal Res2006，41，4： | 1 |
| 6 | Role of the hepatocyte growth factor gene in refractive error显示文摘 | Veerappan S Pertile KK Islam AF | 2010 | Ophthalmology2010，117，2： | 1 |
| 7 | Chromosome translocations in couples with in-vitro fertilization implantation failure显示文摘 | Stem C Pertile M Norris H | 1999 | Hum Reprod1999，14，8： | 1 |
| 8 | Trisomy 16 mosaicism at ehorionic villus sampling and amniocentesis with a normal physical and intellectual outcome显示文摘 | Coman D Gardner RJ Pertile MD | 2010 | Fetal Diagn Ther2010，28，： | 1 |
| 9 | Incidence of en-dophthalmitis in a large series of 23-gauge and 20-gaugetransconjunctival pars plana vitrectomy 显示文摘 | Parolini B Romanelli F Prigione G Pertile G | 2009 | Graefes Arch ClinExp Ophthcdnwl2009，247，7： | 1 |
| 10 | Incidence of endophthalmitis in a large series of 23-gauge and 20-gauge transconjunctival pars plana vitrectomy 显示文摘 | Parolini B Romanelli F Prigione G Pertile G | 2009 | Graefe Arch Clin Exp Ophthalmol2009，247，7： | 1 |
| 11 | Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability显示文摘 | PERTILE M D GRAHAM A N CHOO K H | 2009 | Genome Res2009，19，： | 1 |
| 12 | Accuracy analysis of a pointing mechanism for communication applications显示文摘 | PERTILE M DEBEI S ZACCARIOTTO M | | 0，，10： | 1 |
| 13 | Fine mapping linkage analysis identifies a novel susceptibility locus for myopia on chromosome 2q37 adjacent to but not overlapping MYP12 显示文摘 | Sch~iche M Chen CY Pertile KK Richardson A J Dimai M Mitchell P | 2009 | Mol Vis2009，15，： | 1 |
| 14 | Burnout, compassion fatigue,and compassion satisfaction among staff in conl- munity-based mental health services显示文摘 | Rossi A Cetrano G Pertile R | 2012 | Psychiatry Res2012，200，23： | 1 |
| 15 | Effecacy of a combination vaccine containing MDV CVI988 strain and HVT against challenge with virulent MDV 显示文摘 | Weststrate M W Pertile T L | 1999 | Acta virol1999，43，23： | 1 |
| 16 | Chromosome translocations in couples with in vitro fertilization implantation failure 显示文摘 | Stern C Pertile M Norris H | 1999 | Hum Reprod1999，14，： | 1 |
| 17 | Microsurgery for treatment of peripheral lymphedema:long-term outcome and future perspectives显示文摘 | Campisi C Eretta C Pertile D | 2007 | Microsurgery2007，27，4： | 1 |
| 18 | Melatonin exerts an antidepressant-like effect in the tail suspension test in mice:Evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway 显示文摘 | MANTOVANI M PERTILE R CALIXTO J B | 2003 | Neurosci Lett2003，343，1： | 1 |
| 19 | Reovirus infection in chickens primes splenic adherent macrophages to produce nitric oxide in response to T cell-produced factors显示文摘 | PERTILE T L SHARMA J M WALSER M M | 1995 | Cell Immunol1995，164，2： | 1 |
| 20 | Postoperative complications and intraocular pressure in 943 consecutive cases of 23-gauge transconjunctival pars plana vitrectomy with 1-year follow-up显示文摘 | Parolini B Prigione G Romanelli F Cereda MG Sartore M Pertile G | | 0，，01： | 1 |
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