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| 1 | Sedation-associated hiccups in adults undergoing gastrointestinal endoscopy and colonoscopy显示文摘AIM:To investigate whether the incidence of hiccups in patients undergoing esophagogastroduodenoscopy (EGD) or same-day bidirectional endoscopy (EGD and colonoscopy;BDE) with sedation is different from those without sedation in terms of quantity,duration and typical onset time.METHODS:Consecutive patients scheduled for elective EGD or same-day BDE at the gastrointestinal endoscopy unit or the health examination center were allocated to two groups:EGD without sedation (Group A) and BDE with sedation (Group B).The use of sedation was based on the patients' request.Anesthesiologists participated in this study by administrating sedative drugs as usual.A single experienced gastroenterologist performed both the EGD and the colonoscopic examinations for all the patients.The incidence,duration and onset time of hiccups were measured in both groups.In addition,the association between clinical variables and hiccups were analyzed.RESULTS:A total of 435 patients were enrolled in the study.The incidences of hiccups in the patients with and without sedation were significantly different (20.5% and 5.1%,respectively).The use of sedation for patients undergoing endoscopy was still significantly associated with an increased risk of hiccups (adjusted odds ratio:8.79,P < 0.001) after adjustment.The incidence of hiccups in males under sedation was high (67.4%).The sedated patients who received 2 mg midazolam developed hiccups more frequently compared to those receiving 1 mg midazolam (P = 0.0028).The patients with the diagnosis of gastroesophageal reflux disease (GERD) were prone to develop hiccups (P = 0.018).CONCLUSION:Male patients undergoing EGD or BDE with sedation are significantly more likely to suffer from hiccups compared to those without sedation.Midazolam was significantly associated with an increased risk of hiccups.Furthermore,patients with GERD are prone to develop hiccups. | Chien Cheng Liu Cheng Yuan Lu Chih Fang Changchien Ping Hsin Liu Daw Shyong Perng | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 2 | Mucosal polymerase chain reaction for diagnosing Helicobacter pylori infection in patients with bleeding peptic ulcers显示文摘AIM: Helicobacter pylori(Hpylori) has been linked to chronic gastritis, peptic ulcers, gastric cancer and MALT-lymphoma.Conventional invasive tests are less sensitive than noninvasive tests in diagnosing H pylori infection in patients with bleeding peptic ulcers. Polymerase chain reaction is a sensitive and accurate method for diagnosing H pylori infection. The aim of this study was to evaluate the diagnostic role of mucosal polymerase chain reaction for H pylori infection in patients with bleeding peptic ulcers.METHODS: In patients with bleeding, non-bleeding peptic ulcers and chronic gastritis, we checked rapid urease test,histology, bacterial culture and mucosal polymerase chain reaction for detecting H pylori infection. Positive H pylori infection was defined as positive culture or both a positive histology and a positive rapid urease test. For mucosal polymerase chain reaction of Hpylori, we checked vacA (s1a, s1b, s1c, s2, m1, m1T, m2),iceA1,iceA2 and cag A.RESULTS: Between October 2000 and April 2002, 88 patients with bleeding peptic ulcers (males/females: 60/28, gastric ulcers/duodenal ulcers: 55/33), 81 patients with non-bleeding peptic ulcers (males/females: 54/27, gastric ulcers/duodenal ulcers: 45/36) and 37 patients with chronic gastritis (males/females: 24/13) were enrolled in this study. In patients with bleeding peptic ulcers, non-bleeding peptic ulcers and chronic gastritis, 45 patients (51%), 71 patients (88%)and 20 patients (54%) respectively were found to have positive H pylori infection (P<0.001). In patients with bleeding peptic ulcers, non-bleeding peptic ulcers and chronic gastritis, polymerase chain reaction for H pylori infection was positive in 54 patients (61%), 70 patients (86%) and 20 patients (54%) respectively (P<0.001). The sensitivity,positive predictive value and diagnostic accuracy of mucosal polymerase reaction for Hpylori infection were significantly lower in patients with bleeding peptic ulcers (84%, 79%and 81%) than in patients with non-bleeding peptic ulcers (99%, 99% and 98%) (P<0.001, P<0.01 and P<0.001respectively). The sensitivity, negative predictive value and diagnostic accuracy of mucosal polymerase reaction for H pylori were significantly lower in patients with bleeding peptic ulcers (84%, 83% and 81%) than in patients with chronic gastritis (100%, 100% and 100%) (P= 0.02, P= 0.02and P = 0.001).CONCLUSION: Mucosal polymerase chain reaction for detecting H pylori infection is not reliable in patients with bleeding peptic ulcers. | Hwai-Jeng Lin Wen-Ching Lo Chin-Lin Perng Guan-Ying Tseng Anna Fen-Yau Li Yueh-Hsing Ou | 2005 | World Journal of Gastroenterology2005，11，3： | 3 |
| 3 | Feature-based process plan generation from 3 D DSG inputs显示文摘 | Perng D B Cheng C T | 1994 | Computers Industrial Engineering1994，26，3： | 3 |
| 4 | A strategic website evaluation of online travel agencies显示文摘 | Wen-Chih Chiou Chin-Chao Lin Chyuan Perng | 2010 | Tourism Management2010，，6： | 2 |
| 5 | Prospective Survey for the Etiology and Outcome of Peptic Ulcer Bleeding: A Community Based Study in Southern Taiwan显示文摘 | Chi-Yang Chang Ming-Shiang Wu Ching-Tai Lee Jau-Chung Hwang Chi-Ming Tai Daw-Shyong Perng Chih-Wen Lin Wen-Lun Wang Jung-Der Wang Jaw-Town Lin | 2011 | Journal of the Formosan Medical Association2011，，4： | 2 |
| 6 | A gene capable of blocking a; poptosis can substitute for the herpes simplex virus type latency-associated transcript gene and restore wild-type reactivation levels 显示文摘 | Perng GC Maguen B Jin L | 2002 | J Viral2002，76，3： | 1 |
| 7 | Matrix metalloprotease- 9 induces transforming growth factor-13 (1) production in airway epithelium via activation of epidermal growth factor receptors 显示文摘 | Perng DW Chang KT Su KC | 2011 | Life Sci2011，89，56： | 1 |
| 8 | Efficacy and safety of nemonoxacin versus levofloxacin for community-acquired pneumonia显示文摘 | van Rensburg DJ Perng RP Mitha IH | 2010 | Antimicrob Agents Chemother2010，54，10： | 1 |
| 9 | Assessment of oral bioavailability enhancing approaches for SB-247083 using flow-through cell dissolution testing as one of the screens显示文摘 | PERNG CY KEARNEY AS PALEPU NR | 2003 | Int J Pharm2003，250，1： | 1 |
| 10 | High strain rate tensile properties of an(Al203 particles)-(A1 alloy 6061T6)metal matrix composite显示文摘 | PERNG C C HWANG J R DOONG J L | 1993 | Materials Science and Engineering A1993，171，12： | 1 |
| 11 | A phase Ⅱ trial of gemcitabine plus UFUR combination chemotherapy in non-small-cell lung cancer patients failing previous chemotherapy显示文摘 | Chen YM Perng RP Tsai CM | 2006 | Lung Cancer2006，52，3： | 1 |
| 12 | Hydroxyapatite coating on Ti-6Al-4V alloy using a sol -gel derived precursor显示文摘 | Hsieh M F Perng L H Chin T S | 2002 | Materials Chemistry and Physics2002，，74： | 1 |
| 13 | Endoscopic removal of a huge duodenal Brunner′s glanf adenoma: a new technique显示文摘 | Huang CH Perng CL Yang YH | 1999 | Gastrointest Endosc1999，50，： | 1 |
| 14 | Elevated-temperature,low-cycle fatigue behaviour of an Al2O3p/6061T6 aluminum matrix composite显示文摘 | PERNG C C HWANG J R DOONG J L | 1993 | Composites Science and Technology1993，49，3： | 1 |
| 15 | Dexamethasone and pentastarch produce additive attenuation of ischaemia/ reperfusion lung injury显示文摘 | Chiang CH Wu CP Perng WC | 2000 | Clin Sci2000，99，5： | 1 |
| 16 | Risk of Parkinson disease after depression:a nationwide population-based study显示文摘 | Shen CC Tsai SJ Perng CL | 2013 | J Neurolog2013，81，17： | 1 |
| 17 | The characteristics study on sintering of municipal solid waste incinerator ashes显示文摘 | Wang K S Chiang K Y Perng J K | 1998 | J Hazard Mater1998，59，23： | 1 |
| 18 | Thermal and elec- trical properties of PVD Ru(P) film as Cu diffusion barrier 显示文摘 | Perng D C Hsu K C Tsai S W | 2010 | Microelectronie Engineering2010，87，3： | 1 |
| 19 | A Novel Internal Thread Defect Auto-inspection System显示文摘 | Perng D B Chen S H Chang Yuanshuo | | 0，，5： | 1 |
| 20 | A phase II trial vinorelbine and cisplatin in previously untreated inoperable non-small-cell lung cancer显示文摘 | Perng RP Shih JF Chen YM | 2000 | Am J Clin Oncol2000，23，： | 1 |
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