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| 1 | New Insights into Plant Isoprenoid Metabolism显示文摘Isoprenoids are a hugely diverse family of compounds derived from the C5 precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).Although all free-living organisms synthesize isoprenoids,they are particularly abundant and diverse in plants,with tens of thousands structures known to date.The highest variety of plant isoprenoids are specialized (secondary) metabolites that participate in the interaction of plants with their environment.These include pigments,volatiles,and defense compounds,some of which have applications in industry and agriculture.For example,isoprenoid drugs are used against cancer (taxol) or malaria (artemisin).But plants also synthesize isoprenoids with essential (primary) functions in respiration (ubiquinone),photosynthesis (carotenoids,chlorophylls,tocopherols,phylIoquinones,plastoquinone),membrane architecture (sterols),and growth regulation (brassinosteroids,cytokinins,gibberellins,abscisic acid,strigolactones).Despite their economic importance and biological relevance,our knowledge of the core pathways for the production of the universal isoprenoid precursors IPP and DMAPP in plant cells remained incomplete until the mid-1990s.Impressive progress in the last decade has resulted in the complete elucidation of several isoprenoid pathways,the identification of regulatory mechanisms,the discovery of new functions and properties of specific isoprenoids,and the successful manipulation of isoprenoid biosynthesis in a number of metabolic engineering approaches.In this update article,we will discuss some of the most recent advances in the plant isoprenoid field,focusing on the pathways supplying the C5 precursors in plant cells and the novel insights into regulatory matters. | Pablo Pulido Catalina Perello Manuel Rodriguez-Concepcion | 2012 | Molecular Plant2012，5，5： | 22 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Oyu Tolgoi,Mongolia:Siluro-Devonian porphyry Cu-Au-(Mo) and high-sulfidation Cu mineralization with a Cretaceous chalcocite blanket显示文摘 | PERELLO J COX D GARAMJAV D | 2001 | Economic Geology2001，96，： | 1 |
| 4 | Leptin activates oxytocin neurons ofthe hypothalamic paraventricular nucleus in both controland diet-induced obese rodents 显示文摘 | Perello M Raingo J | 2013 | PLoS One2013，8，59： | 1 |
| 5 | Optimized burst LSP design for absolute QoS guarantees in GMPLS-controlled OBS networks显示文摘 | Pedroso P Perello Oareglio | 2012 | Journal of Optical Communications and Net- working2012，4，2： | 1 |
| 6 | Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions 显示文摘 | Mizisin AP Li L Perello M | 1996 | Am J Physiol1996，270，39： | 1 |
| 7 | Establishing sustainable strategies in urban underground engineering显示文摘 | Esparza J C Perello J C Calvo M A | 2004 | Science and Engineering Ethics2004，10，3： | 1 |
| 8 | Esters in wines: New insight through the establishment of a database of French wines显示文摘 | Antalick G Perello M C de Revel G | 2014 | American Journal of Enology and Viticulture2014，65，3： | 1 |
| 9 | Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing显示文摘 | CAKIR I CYR N E PERELLO M | 2013 | J Bioi Chern2013，288，24： | 1 |
| 10 | Vascular injury by tacks during totally extraperitoneal endoscopic inguinal hernioplasty显示文摘 | Moreno-Egea A Paredes PG Perello JM | 2010 | Surg Laparosc Endosc Percutan Tech2010，20，3： | 1 |
| 11 | GMPLS control plane network design with resilience guarantees 显示文摘 | RUIZ M PERELLO J VELASCO L | 2011 | Journal of Lightwave Technology2011，29，1： | 1 |
| 12 | Ghrelin mediates stress - induced food - reward behavior in mice显示文摘 | Chuang JC Perello M Sakata I | 2011 | J Clin Invest2011，121，7： | 1 |
| 13 | Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C vires-related cirrhosis显示文摘 | PERELLO A ESCORSELL A BRU C | 1999 | Hepatology1999，30，： | 1 |
| 14 | TIPS is a useful longterm derivative therapy for patients with Budd chiarisyndrome uncontrolled by medicaitherapy显示文摘 | Perello A Garcia-Pagan JC Gilabert R | 2002 | Hepatology2002，35，5： | 1 |
| 15 | Hypothalamic Sirt1 regulates food intake in a rodent model system显示文摘 | CAKIR I PERELLO M LANSARI 0 | 2009 | PLoS One2009，4，12： | 1 |
| 16 | Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function,but not food intake,in the absence of full hypothalamic NPY-ergic activity显示文摘 | Moreno G Perello M Gaillard RC | 2005 | Endocrine2005，26，2： | 1 |
| 17 | Human health risks derived from dietary exposure to toxic metals in Catalonia, Spain: temporal trend 显示文摘 | Perello G Llobet JM Gomez - Catalfn J | 2014 | Biological Trace Element Research2014，162，13： | 1 |
| 18 | Influence of septoria tritici on yield, yield components, and test weight of wheat under two nitrogen fertilization conditions显示文摘 | Simon M R Perello A E Cordo C A Struik P C | 2002 | Crop Science2002，42，6： | 1 |
| 19 | Diagnostic and management ofspontaneous rectus sheath hematoma 显示文摘 | Smithson A Ruiz J Perello R | 2013 | Eur J Intern Med2013，24，： | 1 |
| 20 | Factors affecting calcium oxalate dihydrate fragmented calculi regrowth显示文摘 | COSTA-BAUZA A PERELLO J ISERN B | 2006 | BMC Urol2006，6，： | 1 |
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