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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Leptin activates oxytocin neurons ofthe hypothalamic paraventricular nucleus in both controland diet-induced obese rodents 显示文摘 | Perello M Raingo J | 2013 | PLoS One2013，8，59： | 1 |
| 3 | Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions 显示文摘 | Mizisin AP Li L Perello M | 1996 | Am J Physiol1996，270，39： | 1 |
| 4 | Establishing sustainable strategies in urban underground engineering显示文摘 | Esparza J C Perello J C Calvo M A | 2004 | Science and Engineering Ethics2004，10，3： | 1 |
| 5 | Esters in wines: New insight through the establishment of a database of French wines显示文摘 | Antalick G Perello M C de Revel G | 2014 | American Journal of Enology and Viticulture2014，65，3： | 1 |
| 6 | Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing显示文摘 | CAKIR I CYR N E PERELLO M | 2013 | J Bioi Chern2013，288，24： | 1 |
| 7 | GMPLS control plane network design with resilience guarantees 显示文摘 | RUIZ M PERELLO J VELASCO L | 2011 | Journal of Lightwave Technology2011，29，1： | 1 |
| 8 | Ghrelin mediates stress - induced food - reward behavior in mice显示文摘 | Chuang JC Perello M Sakata I | 2011 | J Clin Invest2011，121，7： | 1 |
| 9 | Hypothalamic Sirt1 regulates food intake in a rodent model system显示文摘 | CAKIR I PERELLO M LANSARI 0 | 2009 | PLoS One2009，4，12： | 1 |
| 10 | Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function,but not food intake,in the absence of full hypothalamic NPY-ergic activity显示文摘 | Moreno G Perello M Gaillard RC | 2005 | Endocrine2005，26，2： | 1 |
| 11 | Influence of septoria tritici on yield, yield components, and test weight of wheat under two nitrogen fertilization conditions显示文摘 | Simon M R Perello A E Cordo C A Struik P C | 2002 | Crop Science2002，42，6： | 1 |
| 12 | Sensory and analytical re-evaluation of ' Brett character' 显示文摘 | Romano A Perello M C Lonvaud-Funel A | 2009 | Food Chemistry2009，114，1： | 1 |
| 13 | Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner 显示文摘 | Perello M Sakata I Bimbaum S | 2010 | Biol Psychiatry2010，67，9： | 1 |
| 14 | Dyspepsiaand irritable bowel syndrome after a Salmonellagastroenteritis outbreak : one-year follow-up cohort study显示文摘 | Mearin F Perez--Oliveras M Perello A | 2005 | Gastroenterology2005，129，1： | 1 |
| 15 | Development,validation and application of a specific method for the quantitative determination of wine esters by headspace-solid-phase microextraction-gas chromatography-mass spectrometry显示文摘 | ANTALICK G PERELLO M C DE REVEL G | | 0，，04： | 1 |
| 16 | Variety and variability of glycosidase activities in an Oenococcus oeni strain collection tested with synthetic and natural substrates显示文摘 | GAGNE S LUCAS P M PERELLO M C | | 0，，01： | 1 |
| 17 | I~ptin signaling in Kissl neurons arises after pubertal development 显示文摘 | Cravo R M Frazao R Perello M | 2013 | PLoS One2013，8，58： | 1 |
| 18 | Development, valida-tion and application of a specific method for the quantitative determina-tion of wine esters by headspace-solid-phase microextraction-gas chro-matography-mass spectrometry显示文摘 | ANTALICK G PERELLO M C de REVEL G | 2010 | Food Chemistry2010，121，4： | 1 |
| 19 | A survey of seasonal temperatures and vineyard altitude influ- ences on 2 - methoxy -3 - isobutylpyrazine, C13 - norisoprenoids, and the sensory profile of Brazilian Cabernet sauvignon wines 显示文摘 | Falcao L D de Revel G Perello M C | 2007 | Journal of Agricultural and Food Chemistry2007，55，09： | 1 |
| 20 | Diffusion Entropy technique applied to the study of the market activity显示文摘 | Palatella L Perello J Montero M | 2005 | Physica A2005，355，： | 1 |
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