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	题名	作者	年代	出处	被引量
1	Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.	Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns	2015	World Journal of Gastroenterology2015，21，17：	4
2	Establishing sustainable strategies in urban underground engineering显示文摘	Esparza J C Perello J C Calvo M A	2004	Science and Engineering Ethics2004，10，3：	1
3	Vascular injury by tacks during totally extraperitoneal endoscopic inguinal hernioplasty显示文摘	Moreno-Egea A Paredes PG Perello JM	2010	Surg Laparosc Endosc Percutan Tech2010，20，3：	1
4	Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C vires-related cirrhosis显示文摘	PERELLO A ESCORSELL A BRU C	1999	Hepatology1999，30，：	1
5	TIPS is a useful longterm derivative therapy for patients with Budd chiarisyndrome uncontrolled by medicaitherapy显示文摘	Perello A Garcia-Pagan JC Gilabert R	2002	Hepatology2002，35，5：	1
6	Influence of septoria tritici on yield, yield components, and test weight of wheat under two nitrogen fertilization conditions显示文摘	Simon M R Perello A E Cordo C A Struik P C	2002	Crop Science2002，42，6：	1
7	Diagnostic and management ofspontaneous rectus sheath hematoma 显示文摘	Smithson A Ruiz J Perello R	2013	Eur J Intern Med2013，24，：	1
8	Factors affecting calcium oxalate dihydrate fragmented calculi regrowth显示文摘	COSTA-BAUZA A PERELLO J ISERN B	2006	BMC Urol2006，6，：	1
9	Sensory and analytical re-evaluation of ' Brett character' 显示文摘	Romano A Perello M C Lonvaud-Funel A	2009	Food Chemistry2009，114，1：	1
10	Diagnostic and management of spontaneous rectus sheath hematoma 显示文摘	SMITHSON A RUIZ J PERELLO R	2013	Eur J Intern Med2013，24，：	1
11	Dyspepsiaand irritable bowel syndrome after a Salmonellagastroenteritis outbreak : one-year follow-up cohort study显示文摘	Mearin F Perez--Oliveras M Perello A	2005	Gastroenterology2005，129，1：	1
12	Total effective vascular compliance in patients with cirrhosis: Effects of propranolol 显示文摘	Andreu V Perello A Moitinho E	2002	Hepatol2002，36，3：	1
13	TIPS is a useful long-term derivative therapy for patients with Budd-Chiari syndrome uncontrolled by medical therapy显示文摘	Perello A Garcia-Pagan JC Gilabert R	2002	Hepatology2002，35，1：	1
14	Vascular injury by tacks during totally extraperitoneal endoscopic inguinal hernio- plasty显示文摘	Moreno-Egea A Paredes PG Perello JM	2010	Surg Laparosc Endosc Percutan Tech2010，20，3：	1
15	TIPS is a useful long-term derivative therapy for patients with Budd-Chiari syndrome uncontrolled by medical therapy 显示文摘	Perello A Garcia-Pagan JG Gilabert R	2002	Hepatology2002，35，：	1
16	Coeliac plexus block using computed tomography guidance 显示文摘	Perello A Ashford NS Dolin SJ	1999	Palliat Med1999，13，5：	1
17	Spontaneous bacterial empyema in cirrhotic patients: A prospective study显示文摘	X Xiol JM Castellvi J Guardiola E Sese J Castellote A Perello X Cervantes MJ Iborra	1996	Hepatology1996，，4：	1
18	Leaf blight of wheat caused by Alternaria triticina in Argentina显示文摘	Perello A E Sisterna M N	2006	Plant Patholo- gy2006，55，2：	1
19	Alternaria infectoria species-group associated with black point of wheat in Argentina显示文摘	Perello A Moreno M Sisterna M	2008	Plant Pathology2008，57，2：	1
20	Dyspepsia after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study 显示文摘	Mearin F Perez-Oliveras M Perello A	2005	Gastroenterology2005，129，1：	1

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