3篇
您的检索式：作者名="Per Gullstrand"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion显示文摘AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were randomized into 3 groups:the one-hour segmental ischemia(IRI,n=24)group,the ischemic preconditioning(IPC,n=24)group or the remote ischemic preconditioning(RIPC,n=24)group.The IPC and R-IPC were performed as 10 min of ischemia and 10 min of reperfusion.The iNOS and the IL-1 receptor mRNA in the liver tissue was analyzed with real time PCR.The total Nitrite and Nitrate(NOx)in continuously sampled microdialysate(MD)from the liver was analyzed.In addition,the NOx levels in the serum were analyzed.RESULTS:After 4 h of reperfusion,the iNOS mRNA was significantly higher in the R-IPC(ΔCt:3.44±0.57)group than in the IPC(ΔCt:5.86±0.82)group(P=0.025).The IL-1 receptor transcription activity was reduced in the IPC group(ΔCt:1.88±0.53 to 4.81±0.21),but not in the R-IPC group,during reperfusion(P=0.027).In the MD,a significant drop in the NOx levels was noted in the R-IPC group(12.3±2.2 to 4.7±1.2μmol/L)at the end of ischemia compared with the levels in early ischemia(P=0.008).A similar trend was observed in the IPC group(11.8±2.1 to 6.4±1.5μmol/L),although this difference was not statistically significant.The levels of NOx rose quickly during reperfusion in both groups.CONCLUSION:IPC,but not R-IPC,reduces iNOS and IL-1 receptor transcription during early reperfusion,indicating a lower inflammatory reaction.NOx is consumed in the ischemic liver lobe. | Bergthor Bjornsson Anders Winbladh Linda Bojmar Tommy Sundqvist Per Gullstrand Per Sandstrom | 2014 | World Journal of Gastroenterology2014，20，28： | 5 |
| 2 | Remote or Conventional Ischemic Preconditioning –Local Liver Metabolism in Rats Studied with Microdialysis显示文摘 | Bergthor Bj?rnsson Anders Winbladh Linda Bojmar Lena M. Trulsson Hans Olsson Tommy Sundqvist Per Gullstrand Per Sandstr?m | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 3 | Evaluation of Splenic Embolization in Patients with Portal Hypertension and Hypersplenism显示文摘 | ANDERS ALWMARK STIG BENGMARK PER GULLSTRAND B O JOELSSON ANDERS LUNDERQUIST TORBEN OWMAN | 1982 | Annals of Surgery1982，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员