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您的检索式：作者名="Per Sandstrom"
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| 1 | Role of associating liver partition and portal vein ligation for staged hepatectomy in colorectal liver metastases:A review显示文摘Colorectal cancer is the third most common cancer in the Western world. Approximately half of patients will develop liver metastases, which is the most common cause of death. The only potentially curative treatment is surgical resection. However, many patients retain a to small future liver remnant(FLR) to allow for resection directly. There are therefore strategies todecrease the tumor with neoadjuvant chemotherapy and to increase the FLR. An accepted strategy to increase the FLR is portal vein occlusion(PVO). A concern with this strategy is that a large proportion of patients will never be operated because of progression during the interval between PVO and resection. ALPPS(associating liver partition and portal vein ligation for staged hepatectomy) is a new procedure with a high resection rate. A concern with this approach is the rather high frequency of complications and high mortality, compared to PVO. In this review, it is shown that with ALPPS the resection rate was 97.1% for CRLM and the mortality rate for all diagnoses was 9.6%. The mortality rate was likely lower for patients with CRLM, but some data were lacking in the reports. Due to the novelty of ALPPS, the indications and technique are not yet established but there are arguments for ALPPS in the context of CRLM and a small FLR. | Kristina Hasselgren Per Sandstrom Bergthor Bjornsson | 2015 | World Journal of Gastroenterology2015，21，15： | 16 |
| 2 | Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion显示文摘AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were randomized into 3 groups:the one-hour segmental ischemia(IRI,n=24)group,the ischemic preconditioning(IPC,n=24)group or the remote ischemic preconditioning(RIPC,n=24)group.The IPC and R-IPC were performed as 10 min of ischemia and 10 min of reperfusion.The iNOS and the IL-1 receptor mRNA in the liver tissue was analyzed with real time PCR.The total Nitrite and Nitrate(NOx)in continuously sampled microdialysate(MD)from the liver was analyzed.In addition,the NOx levels in the serum were analyzed.RESULTS:After 4 h of reperfusion,the iNOS mRNA was significantly higher in the R-IPC(ΔCt:3.44±0.57)group than in the IPC(ΔCt:5.86±0.82)group(P=0.025).The IL-1 receptor transcription activity was reduced in the IPC group(ΔCt:1.88±0.53 to 4.81±0.21),but not in the R-IPC group,during reperfusion(P=0.027).In the MD,a significant drop in the NOx levels was noted in the R-IPC group(12.3±2.2 to 4.7±1.2μmol/L)at the end of ischemia compared with the levels in early ischemia(P=0.008).A similar trend was observed in the IPC group(11.8±2.1 to 6.4±1.5μmol/L),although this difference was not statistically significant.The levels of NOx rose quickly during reperfusion in both groups.CONCLUSION:IPC,but not R-IPC,reduces iNOS and IL-1 receptor transcription during early reperfusion,indicating a lower inflammatory reaction.NOx is consumed in the ischemic liver lobe. | Bergthor Bjornsson Anders Winbladh Linda Bojmar Tommy Sundqvist Per Gullstrand Per Sandstrom | 2014 | World Journal of Gastroenterology2014，20，28： | 5 |
| 3 | A Dual-Promoter Gene Orchestrates the Sucrose-Coordinated Synthesis of Starch and Fructan in Barley显示文摘因为它在植物个体发生和复制期间为生长和开发保证精力供应,顺序的糖类合成为植物幸存是重要的。淀粉和 fructan 是在许多 flowering 植物并且在人的食谱的二个重要糖类。理解这协调淀粉和 fructan 合成并且解开植物怎么分配 photosynthates 并且为幸存优先考虑不同糖类合成,能为更大的食物的目的在农业导致改进到谷物 ? 安全和生产质量。这里,我们在大麦从单个基因报导一个系统 ? 雇用二个其他的倡导者,一 intronic/exonic,产生二个重叠顺序却机能上地反对的抄写因素在察觉到蔗糖,潜在地经由 sucrose/glucose/fructose/trehalose 6 磷酸盐发信号。系统在在一个倡导者上察觉一项控制蔗糖的 trans 活动并且安排采用自动调整的机制 ? 由另外的倡导者上的竞争抄写因素绑定的协调淀粉和 fructan 合成。作为在为系统的生理的角色的点的一个案例,我们证明了这个多任务系统能在与 fructan 的定制的数量引起大麦生产健康食物成分被利用。在招待基因的一个 intron/exon-spanning 倡导者的鉴定,与不同功能导致蛋白质,增加植物染色体的复杂性。 | Yunkai Jin Mingliang Fei Sara Rosenquist Lu Jin Suresh Gohil Corine Sandstrom Helena Olsson Cecilia Persson Anna-Stina Hoglund Gunnel Fransson Ying Ruan Per Aman Christer Jansson Chunlin Liu Roger Andersson Chuanxin Sun | 2017 | Molecular Plant2017，10，12： | 0 |
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