|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs显示文摘Dear Editor,Most human genetic diseases arise from mutations such as insertion,deletion,or point mutations(Landrum et al.,2016).CRISPRCas system has been repurposed to correct pathogenic mutations in a variety of genetic diseases(Choi et al.,2022).There are many concerns about using CRISPR-mediated double-stranded DNA breaks(DSBs)for therapeutic purposes,primarily due to off-targeted mutations(Kosicki et al.,2018).Nevertheless,base editing cannot correct deletions,insertions,or some point mutations such as transversion mutations.Prime editing has its advantages of precisely correct point mutations,small insertions,or deletions in animal cells(Anzalone et al.,2019)and plants(Lin et al.,2020).However,prime editing efficiency varies among genomic sites or cell types(Chen et al.,2021;Nelson et al.,2022). | Ying Feng Siyuan Liu Qiqin Mo Pengpeng Liu Xiao Xiao Hanhui Ma | 2023 | Protein & Cell2023，14，4： | 1 |
| 2 | Synergistic lubricating effect of graphene/ionic liquid composite material used as an additive显示文摘We prepared a graphene/ionic liquid(G/IL)composite material by the hybridization of G and an IL for use as a lubricating oil additive.The friction coefficient and wear volume of a base oil containing 0.04 wt%of the G/IL composite was reduced by 45%and 90%,respectively.Furthermore,the base oil containing the G/IL composite exhibited better lubricating properties than the base oil containing G,IL,or a mixture of IL and G at the same mass fraction.A synergistic lubrication mechanism was also revealed.The G/IL composite was adsorbed and deposited on the wear surface,forming a more ordered protective film and a unique tribochemical reaction film during rubbing.Therefore,the G/IL composite exhibited the synergistic lubricating effects of G and IL,which significantly improved the lubricating performance of the base oil.This study also suggested a way to limit the out-of-plane puckering of G at the macroscale. | Lincong LIU Ming ZHOU Youtang MO Pengpeng BAI Qilin WEI Long JIN Shengli YOU Mingyue WANG Liangchuan LI Xin CHEN Xiao LI Yu TIAN | 2021 | Friction2021，9，6： | 1 |
| 3 | Research Article In situ reconstruction induced oxygen-deficient multiphase Cu based species hybridized with Ni single atoms as tandem platform for CO_(2) electroreduction显示文摘Tandem catalysis,capable of decoupling individual steps,provides a feasible way to build a high-efficiency CO_(2) electro-conversion system for multicarbons(C_(2+)).The construction of electrocatalytic materials is one of focusing issues.Herein,we fabricated a single atom involved multivalent oxide-derived Cu composite material and found it inclined to reconstruct into oxygen-deficient multiphase Cu based species hybridized with monatomic Ni on N doped C matrix.In this prototype,rapid CO generation and C-C coupling are successively achieved on NiN4 sites and surface amorphized Cu species with defects,resembling a micro-production line.In this way,the in situ formed tandem catalyst exhibited a high Faradaic efficiency(FE)of~78%for C_(2+)products along with satisfactory durability over 50 h.Particularly,the reconstruction-induced amorphous layer with abundant asymmetric sites should be favorable to improve the ethanol selectivity(FE:63%),which is about 10 times higher than that of the non-tandem Cu-based contrast material.This work offers a new approach for manipulating tandem catalyst systems towards enhancing C_(2+)products. | Juzhe Liu Yuheng Wang Pengpeng Mo Feng Yang Kaiqi Jiang Zhixiang Cheng Yuxuan Liu Zhiyi Sun Zheng Liu Yimei Zhang Wenxing Chen | 2024 | Nano Research2024，17，5： | 0 |
| 4 | Interfacial oxidized Pd species dominate catalytic hydrogenation of polar unsaturated bonds显示文摘The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired reactions.However,the complexity of supported noble metal catalysts has led to controversy over the locations of catalytically active sites(e.g.,metal,support,and metal/support interface).Here we develop a structurally controllable catalyst system(Pd/SBA-15)to reveal the catalytic active sites for the selective hydrogenation of ketones to alcohol using acetophenone hydrogenation as model reaction.Systematic investigations demonstrated that unsupported Pd nanocrystals have no catalytic activity for acetophenone hydrogenation.However,oxidized Pd species were catalytically highly active for acetophenone hydrogenation.The catalytic activity decreased with the decreased oxidation state of Pd.This work provides insights into the hydrogenation mechanism of ketones but also other unsaturated compounds containing polar bonds,e.g.,nitrobenzene,N-benzylidene-benzylamine,and carbon dioxide. | Pengyao You Shaoqi Zhan Pengpeng Ruan Ruixuan Qin Shiguang Mo Yazhou Zhang Kunlong Liu Lansun Zheng Nanfeng Zheng | 2024 | Nano Research2024，17，1： | 0 |
| 5 | Non-contact biomimetic mechanism for selective hydrogenation of nitroaromatics on heterogeneous metal nanocatalysts显示文摘While the enzymatic reduction of unsaturated compounds usually has high specificity,highly selective reduction processes are hardly realized by heterogeneous industrial catalysts,which is critical for the green production of many fine chemicals.Here,we report an unexpected discovery of a biomimetic behavior of dicyandiamide(DICY)-modified Pt nanocatalysts for the green hydrogenation of a wide range of nitroaromatics.We demonstrate that the surface modification by DICY not only prevents the direct contact of nitroaromatic reactants with Pt surface but also induces an effective non-contact hydrogenation mechanism mediated by protons and electrons.In such a process,the DICY layer serves as a“semi-permeable membrane”to allow the permeation of H_(2) molecules for being activated into electrons and protons at the Pt-DICY interface.With the generation of separated protons and electrons,the nitro group with strong electrophilic properties can be hydrogenated through the electron transfer followed by the proton transfer,which is facilitated by the hydrogen bonding network formed by protonated DICY.The unique mechanism makes it highly directional toward the hydrogenation of nitro groups without side reactions.Owing to its capability to largely eliminate the waste generation,the developed Pt-DICY catalysts have been successfully applied for the green industrial production of many important aniline intermediates. | Wenting Zhou Laiyang Li Ruixuan Qin Jiaxin Zhu Shengjie Liu Shiguang Mo Zaifa Shi Huihuang Fang Pengpeng Ruan Jun Cheng Gang Fu Nanfeng Zheng | 2022 | Science China Chemistry2022，65，4： | 0 |
| 6 | Pecan kinome:classification and expression analysis of all protein kinases in Carya illinoinensis显示文摘Protein kinases(PKs)are involved in plant growth and stress responses,and constitute one of the largest superfamilies due to numerous gene duplications.However,limited PKs have been functionally described in pecan,an economically important nut tree.Here,the comprehensive identification,annotation and classification of the entire pecan kinome are reported.A total of 967 PK genes were identified from the pecan genome,and further classified into 20 different groups and 121 subfamilies using the kinase domain sequences,which were verified by phylogenetic analysis.The receptor-like kinase(RLK)group contained 565 members,which constituted the largest group.Gene duplication contributed to the expansion of pecan kinome,169 segmental duplication events including 285 PK genes were found,and the Ka/Ks ratio revealed they experienced strong negative selection.The RNA-Seq data of PK genes in pecan were further analyzed at the subfamily level,and different PK subfamilies performed various expression patterns across pecan embryo development or drought treatment,suggesting PK genes in pecan are involved in embryo development and drought stress response.Taken together,this study provides insight into the classification,expansion,evolution,and expression of pecan PKs.Our findings regarding expansion,expression and co-expression analyses lay a good foundation for future research to understand the roles of pecan PKs,and more efficiently determine the key candidate genes. | Kaikai Zhu Pinghua Fan Hui Liu Juan Zhao Pengpeng Tan Zhenghai Mo Fangren Peng | 2021 | Forestry Research2021，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员