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| 1 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 2 | Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats显示文摘Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce sperm count; however, the underlyingmechanisms remain unknown. Herein, we show that oral administration of BPA (2 μg/kg) for consecutive 14 daysin adult rats (BPA rats) significantly reduced the sperm count and the number of germ cells compared to controls.The serum levels of testosterone and follicle-stimulating hormone (FSH), as well as the level of GnRH mRNA inBPA rats were lower than those of control rats. Testosterone treatment could partially rescue the reduction of germcells in BPA rats. Notably, the number of apoptotic germ cells was significantly increased in BPA rats, which wasinsensitive to testosterone. Furthermore, the levels of Fas, FasL and caspase-3 mRNA in the testicle of BPA ratswere increased in comparison with controls. These results indicate that exposure to a low dose of BPA impairsspermatogenesis through decreasing reproductive hormones and activating the Fas/FasL signaling pathway. | Pengpeng Jin Xiaoli Wang Fei Chang Yinyang Bai Yingchun Li Rong Zhou Ling Chen | 2013 | The Journal of Biomedical Research2013，27，2： | 5 |
| 3 | MoS_(2) reinforced PEEK composite for improved aqueous boundary lubrication显示文摘Polyether-etherketone(PEEK)is a corrosion-resistant material that has been widely used in aqueous lubrication.However,its anti-wear performance must be improved for its application in the industry.In this study,to improve the anti-wear performance of PEEK for aqueous boundary lubrication,PEEK/MoS_(2)composites were prepared by ball-milling and spark plasma sintering processes.A competitive MoS_(2)mechanism between the low shear strength property and the role of promoting wear debris generation influences the anti-wear performance of PEEK/MoS_(2)composites.Experiments demonstrated that the coefficients of friction(COF)and wear rate of PEEK composite with 0.25 wt%MoS_(2)were significantly reduced 68%and 94%,respectively.Furthermore,this was the first time that a PEEK composite could achieve a COF of less than 0.05 in aqueous boundary lubrication.Its anti-wear performance was verified to be better than that of PEEK/carbon fiber(CF)and Thordon composites.The PEEK/MoS_(2)composite may be a potential material for underwater equipment because of its outstanding anti-wear performance in aqueous boundary lubrication. | Xin HOU Pengpeng BAI Jingyang LI Yuanzhe LI Hui CAO Xiangli WEN Yonggang MENG Liran MA Yu TIAN | 2023 | Friction2023，11，9： | 2 |
| 4 | Synergistic lubricating effect of graphene/ionic liquid composite material used as an additive显示文摘We prepared a graphene/ionic liquid(G/IL)composite material by the hybridization of G and an IL for use as a lubricating oil additive.The friction coefficient and wear volume of a base oil containing 0.04 wt%of the G/IL composite was reduced by 45%and 90%,respectively.Furthermore,the base oil containing the G/IL composite exhibited better lubricating properties than the base oil containing G,IL,or a mixture of IL and G at the same mass fraction.A synergistic lubrication mechanism was also revealed.The G/IL composite was adsorbed and deposited on the wear surface,forming a more ordered protective film and a unique tribochemical reaction film during rubbing.Therefore,the G/IL composite exhibited the synergistic lubricating effects of G and IL,which significantly improved the lubricating performance of the base oil.This study also suggested a way to limit the out-of-plane puckering of G at the macroscale. | Lincong LIU Ming ZHOU Youtang MO Pengpeng BAI Qilin WEI Long JIN Shengli YOU Mingyue WANG Liangchuan LI Xin CHEN Xiao LI Yu TIAN | 2021 | Friction2021，9，6： | 1 |
| 5 | A novel yeast bio- template route to synthesize Cr2 03 hollow microspheres 显示文摘 | Bai Bo Wang Pengpeng Wu Le | 2009 | Mater Chem Phys2009，114，： | 1 |
| 6 | Effects of clinorotation on COL-1A1-EGFP gene expression显示文摘 | DAI Zhongquan LI Yinghui DING Bai ZHANG Yuguo LIU Weiquan LIU Pengpeng | 2005 | 中国生物学文摘2005，19，7： | 0 |
| 7 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 8 | Robust scalable reversible strong adhesion by gecko-inspired composite design显示文摘Bio-inspired reversible adhesion has significant potential in many fields requiring flexible grasping and manipulation,such as precision manufacturing,flexible electronics,and intelligent robotics.Despite extensive efforts for adhesive synthesis with a high adhesion strength at the interface,an effective strategy to actively tune the adhesion capacity between a strong attachment and an easy detachment spanning a wide range of scales has been lagged.Herein,we report a novel soft-hard-soft sandwiched composite design to achieve a stable,repeatable,and reversible strong adhesion with an easily scalable performance for a large area ranging from~1.5 to 150 cm2 and a high load ranging from~20 to 700 N.Theoretical studies indicate that this design can enhance the uniform loading for attachment by restraining the lateral shrinkage in the natural state,while facilitate a flexible peeling for detachment by causing stress concentration in the bending state,yielding an adhesion switching ratio of~54 and a switching time of less than~0.2 s.This design is further integrated into versatile grippers,climbing robots,and human climbing grippers,demonstrating its robust scalability for a reversible strong adhesion.This biomimetic design bridges microscopic interfacial interactions with macroscopic controllable applications,providing a universal and feasible paradigm for adhesion design and control. | Xiaosong LI Pengpeng BAI Xinxin LI Lvzhou LI Yuanzhe LI Hongyu LU Liran MA Yonggang MENG Yu TIAN | 2022 | Friction2022，10，8： | 0 |
| 9 | Quantification/mechanism of interfacial interaction modulated by electric potential in aqueous salt solution显示文摘With the development of surface and interface science and technology,methods for the online modulation of interfacial performance by external stimuli are in high demand.Switching between ultra-low and high friction states is a particular goal owing to its applicability to the development of precision machines and nano/micro-electromechanical systems.In this study,reversible switching between superlubricity and high friction is realized by controlling the electric potential of a gold surface in aqueous salt solution sliding against a SiO_(2) microsphere.Applying positive potential results creates an ice-like water layer with high hydrogen bonding and adhesion at the interface,leading to nonlinear high friction.However,applying negative potential results in free water on the gold surface and negligible adhesion at the interface,causing linear ultra-low friction(friction coefficient of about 0.004,superlubricity state).A quantitative description of how the external load and interfacial adhesion affected friction force was developed,which agrees well with the experimental results.Thus,this work quantitatively reveals the mechanism of potential-controlled switching between superlubricity and high-friction states.Controlling the interfacial behavior via the electric potential could inspire novel design strategies for nano/micro-electromechanical and nano/micro-fluidic systems. | Shaowei LI Pengpeng BAI Yuanzhe LI Noshir SPESIKA Yonggang MENG Liran MA Yu TIAN | 2021 | Friction2021，9，3： | 0 |
| 10 | Improvement of hydrogen permeation barrier performance by iron sulphide surface films显示文摘Fe–S compounds with hexagonal crystal structure are potential hydrogen permeation barrier during H2S corrosion. Hexagonal system Fe–S films were prepared on carbon steel through corrosion and CVD deposition, and the barrier effect of different Fe–S films on hydrogen permeation was tested using electrochemical hydrogen permeation method. After that, the electrical properties of Fe–S compound during phase transformation were measured using thermoelectric measurement system. Results show that the mackinawite has no obvious barrier effect on hydrogen penetration, as a p-type semiconductor, and pyrrhotite (including troilite) has obvious barrier effect on hydrogen penetration,as an n-type semiconductor. Hydrogen permeation tests showed peak permeation performance when the surface was deposited with a continuous film of pyrrhotite (Fe_(1–x)S) and troilite. The FeS compounds suppressed hydrogen permeation by the promotion of the hydrogen evolution reaction, semiconducting inversion from p-to n-type, and the migration of ions at the interface. | Pengpeng Bai Shaowei Li Jie Cheng Xiangli Wen Shuqi Zheng Changfeng Chen Yu Tian | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，9： | 0 |
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