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| 1 | Visualization of the complex structure and stress field inside rock by means of 3D printing technology显示文摘Accurate characterization and visualization of the complex inner structure and stress distribution of rocks are of vital significance to solve a variety of underground engineering problems. In this paper, we incorporate several advanced technologies, such as CT scan, three-dimensional(3D) reconstruction, and 3D printing, to produce a physical model representing the natural coal rock that inherently contains complex fractures or joints. We employ 3D frozen stress and photoelastic technologies to characterize and visualize the stress distribution within the fractured rock under uniaxial compression. The 3D printed model presents the fracture structures identical to those of the natural prototype. The mechanical properties of the printed model,including uniaxial compression strength, elastic modulus,and Poisson's ratio, are testified to be similar to those of the prototype coal rock. The frozen stress and photoelastic tests show that the location of stress concentration and the stress gradient around the discontinuous fractures are in good agreement with the numerical predictions of the real coalsample. The proposed method appears to be capable of visually quantifying the influences of discontinuous,irregular fractures on the strength, deformation, and stress concentration of coal rock. The method of incorporating3 D printing and frozen stress technologies shows a promising way to quantify and visualize the complex fracture structures and their influences on 3D stress distribution of underground rocks, which can also be used to verify numerical simulations. | Yang Ju Heping Xie Zemin Zheng Jinbo Lu Lingtao Mao Feng Gao Ruidong Peng | 2014 | Chinese Science Bulletin2014，59，36： | 41 |
| 2 | Energy analysis and criteria for structural failure of rocks显示文摘The intrinsic relationships between energy dissipation,energy release,strength and abrupt structural failure are key to understanding the evolution of deformational processes in rocks.Theoretical and experimental studies confirm that energy plays an important role in rock deformation and failure.Dissipated energy from external forces produces damage and irreversible deformation within rock and decreases rock strength over time.Structural failure of rocks is caused by an abrupt release of strain energy that manifests as a catastrophic breakdown of the rock under certain conditions.The strain energy released in the rock volume plays a pivotal role in generating this abrupt structural failure in the rocks.In this paper,we propose criteria governing(1) the deterioration of rock strength based on energy dissipation and(2) the abrupt structural failure of rocks based on energy release.The critical stresses at the time of abrupt structural failure under various stress states can be determined by these criteria.As an example,the criteria have been used to analyze the failure conditions of surrounding rock of a circular tunnel. | Heping Xie Liyun Li Ruidong Peng Yang Ju | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 39 |
| 3 | Numerical simulation of mechanisms of deformation,failure and energy dissipation in porous rock media subjected to wave stresses显示文摘The pore characteristics,mineral compositions,physical and mechanical properties of the subarkose sandstones were acquired by means of CT scan,X-ray diffraction and physical tests.A few physical models possessing the same pore characteristics and matrix properties but different porosities compared to the natural sandstones were developed.The 3D finite element models of the rock media with varied porosities were established based on the CT image processing of the physical models and the MIMICS software platform.The failure processes of the porous rock media loaded by the split Hopkinson pressure bar(SHPB) were simulated by satisfying the elastic wave propagation theory.The dynamic responses,stress transition,deformation and failure mechanisms of the porous rock media subjected to the wave stresses were analyzed.It is shown that an explicit and quantitative analysis of the stress,strain and deformation and failure mechanisms of porous rocks under the wave stresses can be achieved by using the developed 3D finite element models.With applied wave stresses of certain amplitude and velocity,no evident pore deformation was observed for the rock media with a porosity less than 15%.The deformation is dominantly the combination of microplasticity(shear strain),cracking(tensile strain) of matrix and coalescence of the cracked regions around pores.Shear stresses lead to microplasticity,while tensile stresses result in cracking of the matrix.Cracking and coalescence of the matrix elements in the neighborhood of pores resulted from the high transverse tensile stress or tensile strain which exceeded the threshold values.The simulation results of stress wave propagation,deformation and failure mechanisms and energy dissipation in porous rock media were in good agreement with the physical tests.The present study provides a reference for analyzing the intrinsic mechanisms of the complex dynamic response,stress transit mode,deformation and failure mechanisms and the disaster mechanisms of rock media. | JU Yang1,2,WANG HuiJie1,YANG YongMing1,HU QinAng3 & PENG RuiDong1 1 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rock and Concrete,China University of Mining and Technology,Beijing 100083,China 2 Department of Mechanical and Manufacturing Engineering,University of Calgary,Calgary,Alberta,T2N 1N4,Canada 3 School of Environment and Civil Engineering,College of Engineering,Oklahoma State University,Stillwater,OK 74078,USA | 2010 | Science China(Technological Sciences)2010，53，4： | 32 |
| 4 | Energy analysis for damage and catastrophic failure of rocks显示文摘The development history and current state of studies on the characteristics and mechanisms of deformation and failure of rock materials were briefly reviewed from the viewpoint of energy.The main scope and the achievable objectives of the energy-based research system were expatiated.It was validated by experiments that the damage process of rocks can be well described by the rock damage evolution equation established based on energy dissipation.It was found from the uniaxial compression and biaxial compression tests that only a small proportion of the total input energy in hard rocks is dissipated before peak load and a large proportion in soft rocks is dissipated before peak load.For both hard and soft rocks,the energy dissipated after peak load accounts for a greater proportion.More energy would be required for rock failure under equal biaxial compression than under unequal biaxial compression.The total absorbed energy is different for rock failure under high-rate loading and low-rate loading.More fragmented failure pattern usually corresponds to higher energy absorption.The mesoscopic analysis on the damage and failure of bedded salt rocks showed that the energy dissipation is prominent and the total absorbed energy for rock failure is low when cracks propagate in the weak mud interlayer while it is contrary when cracks propagate in the salt rock.The energy accumulation,transfer,dissipation and release during the failure process of tunnel with impending failure under disturbance were analyzed theoretically based on the elastoplastic mechanics theory.Furthermore,the spatial distribution of energy dissipation and energy release of fractured rocks under unloading was simulated numerically.It was demonstrated that energy is likely to be released from the weakest surface under compression,which triggers the global failure of rocks. | XIE HePing 1,2,LI LiYun 2,1,JU Yang 2,PENG RuiDong 2 & YANG YongMing 2 1 Sichuan University,Chengdu 610065,China 2 State Key Laboratory of Coal Resources and Safe Mining,Beijing Key Laboratory of Fracture and Damage Mechanics of Rock and Concrete,China University of Mining and Technology,Beijing 100083,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 29 |
| 5 | Computation of fractal dimension of rock pores based on gray CT images显示文摘The characterization of pore structure in rocks is relevant in determining their various mechanical behaviors. Digital image processing methods integrated with fractal theory were applied to analyze images of rock slices obtained from industry CT, elucidating the characteristics of rock pore structure and the relationship between porosity and fractal dimensions. The gray values of pixels in CT images of rocks provide comprehensive results with respect to the attenuation coefficients of various materials in corresponding rock elements, and these values also reflect the effect of rock porosity at various scales. A segmentation threshold can be determined by inverse analysis based on the pore ratios that are measured experimentally, and subsequently binary images of rock pores can be obtained to study their topological structures. The fractal dimension of rock pore structure increases with an increase in rock pore ratio, and fractal dimensions might differ even if pore ratios are the same. The more complex the structure of a rock, the larger the fractal dimension becomes. The experimental studies have validated that fractal dimension calculated directly from gray CT images of rocks can give an effective complementary parameter to use alongside pore ratios and they can suitably represent the fractal characteristics of rock pores. | PENG RuiDong YANG YanCong JU Yang MAO LingTao YANG YongMing | 2011 | Chinese Science Bulletin2011，56，31： | 25 |
| 6 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 7 | Visual representation and characterization of three-dimensional hydrofracturing cracks within heterogeneous rock through 3D printing and transparent models显示文摘 | Peng Liu Yang Ju Pathegama G. Ranjith Zemin Zheng Li Wang Ayai Wanniarachchi | 2016 | International Journal of Coal Science & Technology2016，3，3： | 21 |
| 8 | Research on in-situ condition preserved coring and testing systems显示文摘As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become urgent.Traditional coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured parameters.Herein,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed environment.The ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing film.The ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are realized.CH_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/min.The average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is achieved.The error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact test.The system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes. | He-Ping Xie Tao Liu Ming-Zhong Gao Ling Chen Hong-Wei Zhou Yang Ju Feng Gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan Gao Cong Li Zhi-Qiang He Ming-Qing Yang Zhi-Yu Zhao | 2021 | Petroleum Science2021，18，6： | 19 |
| 9 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 10 | Protective effects of Batroxobin on spinal cord injury in rats显示文摘Expansion of the secondary injury following primary spinal cord injury is a major pathological event that increases destruction in the spinal cord, so measures to reduce secondary injury are needed. Our previous study demonstrated that, at the front of the expanding secondary injury in the spinal cord, there is an ischemic area in which many neurons can still be rescued. Therefore, enhancement of blood circulation in the cord may be helpful, and indeed, we found that a traditional Chinese medicine, shu-xue-tong, efficiently reduces the secondary injury. The aim of the present study was to investigate the effect of reducing fibrinogen with Batroxobin, a drug widely used clinically for ischemia, in rats with spinal cord contusion. We found that both 2 and 4 Batroxobin units (BU)/kg efficiently decreased the plasma fibrinogen, and 2 BU/kg significantly increased spinal blood flow, enhanced neuronal survival, mitigated astrocyte and microglia activation, and improved locomotor recovery. However, 4 BU/kg had no effect on the secondary spinal cord injury. These data suggest that Batroxobin has multiple beneficial effects on spinal cord injury, indicating a potential clinical application. | Hong Fan Xia Liu Hai-Bin Tang Peng Xiao Ya-Zhou Wang Gong Ju | 2013 | Neuroscience Bulletin2013，29，4： | 11 |
| 11 | Fluid-structure Interaction Analysis and Lifetime Estimation of a Natural Gas Pipeline Centrifugal Compressor under Near-choke and Near-surge Conditions显示文摘Up to present, there have been no studies concerning the application of fluid-structure interaction(FSI) analysis to the lifetime estimation of multi-stage centrifugal compressors under dangerous unsteady aerodynamic excitations. In this paper, computational fluid dynamics(CFD) simulations of a three-stage natural gas pipeline centrifugal compressor are performed under near-choke and near-surge conditions, and the unsteady aerodynamic pressure acting on impeller blades are obtained. Then computational structural dynamics(CSD) analysis is conducted through a one-way coupling FSI model to predict alternating stresses in impeller blades. Finally, the compressor lifetime is estimated using the nominal stress approach. The FSI results show that the impellers of latter stages suffer larger fluctuation stresses but smaller mean stresses than those at preceding stages under near-choke and near-surge conditions. The most dangerous position in the compressor is found to be located near the leading edge of the last-stage impeller blade. Compressor lifetime estimation shows that the investigated compressor can run up to 102.7 h under the near-choke condition and 200.2 h under the near-surge condition. This study is expected to provide a scientific guidance for the operation safety of natural gas pipeline centrifugal compressors. | JU Yaping LIU Hui YAO Ziyun XING Peng ZHANG Chuhua | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 11 |
| 12 | Composition, spatial distribution, and environmental significance of water ions in Pumayum Co catchment, southern Tibet显示文摘主要阳离子(Mg2+ , Ca2+ , Na+ ,和 K+) 和阴离子的化学(HCO3 ? , SO4 2 ? ,并且 Cl ?) 在普麦乌姆湖的水里,公司和它的流入河被学习,在各种各样的流入河和湖之中揭示明显的离子的差别。湖水的化学类型是 Mg2+-Ca2+-HCO3 ?-SO4 2+ ,但是主要流入河的主要离子是 Ca2+-Mg2+-HCO3 ? 。在 Jiaqu 河的湖入口,主要流入河,有在深度以内的水化学的重要变化不到 2 m。然而,它在湖的另外的区域是几乎同类的。与水化学和湖水的氧同位素的分发的证据,因此,一个结论能被构画出那条 Jiaqu 河在沉没三角洲上在水的 hydrochemistry 上有不同效果,而这为另外的河不是事实。吉布斯阴谋表明负责控制湖水的化学作文的主导的机制是在排水区域捱过的岩石。离子比率和第三的阴谋进一步探索了控制集水的水化学的主要过程,即,捱过的碳酸盐,捱过的黄铁矿,并且硅酸盐捱过。在河水和湖水之间的不同 hydrochemistry 特征可以源于 CaCO3 降水。调查结果将在湖在 paleolimnological 研究有益于碳酸盐的环境意义的解释。 | ZHU Liping JU Jianting WANG Yong XIE Manping WANG Junbo PENG Ping ZHEN Xiaolin LIN Xiao | 2010 | Journal of Geographical Sciences2010，20，1： | 9 |
| 13 | Simulation and visualization of the displacement between CO2 and formation fluids at pore-scale levels and its application to the recovery of shale gas显示文摘 | Peng Hou Yang Ju Feng Gao Jianguo Wang Jian He | 2016 | International Journal of Coal Science & Technology2016，3，4： | 8 |
| 14 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 15 | Toughness and characterization of reactive powder concrete with ultra-high strength显示文摘A number of three-point bending and fracture tests of 200 MPa-level reactive powder concrete (RPC) with the various fiber contents have been conducted to probe the nature and characteristics of tough- ness of RPC200. The contribution of the embedded fibers to improving the crack-resistant capacity, energy absorption capacity and toughness with various deformation mechanisms has been analyzed. Taking account of that the first-crack deformation, peak-load deformation and their improvement varied with the fiber contents and that the deformation mechanism affected differently the performance at the first crack and the peak load, we took the peak-load deformation of plain RPC200 as the reference de- formation to measure the toughness of fibered RPC200. Two toughness indices T2(n?1)(n) and FT2(n?1)(n) have been formulated based on P-δ responses and P-CMOD responses. The indices quantify the tough- ness of RPC200 with the various deformation mechanisms relative to perfectly elastoplastic materials by setting the toughness level 2(n?1) as the initial reference. It is shown that the toughness index T2(n?1)(n) reflects the function of fibers to improve the toughness of RPC with the deformation throughout specimens, but overestimates the contribution to enhancing the toughness in post-peak periods. It underestimates, on other hands, the contribution to improving the toughness in the period from the first crack to the peak load. In contrast, the toughness index FT2(n?1)(n) properly presents the capability that fibers absorb energy and constrain crack propagation in the matrix when the deformation is con- centrated on the open crack. The proposed index unveils the contribution of fibers to toughening RPC200 both in the period from the first-crack to the peak load and in the period of post peak. This characterization method not only reveals the nature of toughness but also levels the toughness of RPC200. It could provide a way to establish an objective toughness characterization for RPC200 and facilitate its applications. | Yang Ju HongBin Liu Jian Chen YuDan Jia PeiHuo Peng | 2009 | Science China(Technological Sciences)2009，52，4： | 7 |
| 16 | Molecular and functional characterization of sulfiredoxin homologs from higher plants显示文摘由在氧化 peroxiredoxin 减少 cysteine-sulfinic 酸, sulfiredoxin (Srx ) 在酵母和人的房间在氧化压力抵抗起一个重要作用。这里,我们从更高的植物报导 Srx 相当或相同的事物的第一分子、功能的描述。生物信息的分析揭示了把序列编码为两张单音的简易窄床和 dicot 植物种类的潜在的 Srx 的存在。通常认为的植物 Srx 蛋白质从酵母和人展出了重要身份到他们的 orthologs,并且为催化作用包含了保存签名顺序和残余必需品。然而,植物 Srxs 不同于酵母和人的 orthologs,都被预言在他们的主要结构拥有叶绿体运输肽。从 Arabidopsis 和米饭的 Srx 蛋白质(指定了为 AtSrx 和 OsSrx,分别地) 在 SRX1 删除酵母房间的 Srx 的补充功能的缺乏。AtSrx 的 GFP 熔化蛋白质在 Arabidopsis 叶肉原物被指向到叶绿体。AtSrx 抄写在植物、繁殖的机关发生了,并且最高的抄本水平在叶子被检测。在氧化应力下面, AtSrx 抄本水平实质地被增加,哪个有在维持被发现必要的 2-Cys peroxiredoxins 的提高的抄写的 paralleled 叶绿体氧化还原作用平衡。除了氧化应力, osmotic/water 赤字或冷处理也提起了 AtSrx 抄本水平。与上面的调查结果一致, AtSrx 的猛烈异种是显著地,产生氧化的更多比野类型 Arabidopsis 强调植物。总起来说,这个工作的结果在是必要的让工厂应付氧化应力的更高的工厂显示功能的 Srx 相当或相同的事物的存在。 | Xian Peng Liu Xue Ying Liu Juan Zhang Zong Liang Xia Xin Liu Huan Ju Qin Dao Wen Wang | 2006 | Cell Research2006，16，3： | 7 |
| 17 | Hydrodynamic process of Tibetan Plateau lake revealed by grain size:Case study of Pumayum Co显示文摘Under the background of global warming,some lakes on the Tibetan Plateau(TP) are potentially sensitive to temperature change.With a case study of Pumayum Co,where glacier meltwater is important to supply(we call this a glacier-fed lake hereafter),we analyze the sensitivity of lake sediment grain size to temperature change.This is done by resolving the modern hydrodynamic process,coupled with comparison of paleoclimatic proxies.According to the spatial distributions of parameters,percentage of grain size and the grain size frequency distribution curve,hydrodynamic processes are analyzed.Five clastic sedimentation types are thereby discriminated.In the open lake area,suspended load transport is the main transport agent.Grain Size Trend Analysis(GSTA),a sediment dynamics model,reveals a trend toward eastward transport.This indicates that the largest and glacier-fed river,the Jiaqu River,influences the entire lake(not just the subsurface alluvial fan),and that lake sediment grain size may serve as a temperature indicator.Time series comparison between grain size of a short core from the central lake and meteorological data confirms this temperature indication,which in turn shows reliability of the method discriminating the hydrodynamic process.This case study will improve the ability of paleoclimatic reconstruction using lake sediment in glacier-fed lakes on the Tibetan Plateau. | JU JianTing ZHU LiPing FENG JinLiang WANG JunBo WANG Yong XIE ManPing PENG Ping ZHEN XiaoLin LÜXinMiao | 2012 | Chinese Science Bulletin2012，57，19： | 7 |
| 18 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 19 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 20 | Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain显示文摘AIM:To detect whether there is Helicobacter pylori(Hpylori)colonization in the pharynx mucous membraneof healthy people and whether chronic pharyngitis is re-lated to Hpylori infection.METHODS:Fifty cases of chronic pharyngitis refrac-tory over three months were prospectively studied fromMarch 2004 to August 2004 in the otolaryngology outpa-tient department of the Second Hospital of Xi'an JiaotongUniversity.Template-directed dye-terminator incorporat-ed with fluorescence polarization detection(TDI-FP)andmodified Giemsa stain were used to examine pharynxmucous membrane tissue for Hpylori colonization in thepatients with chronic pharyngitis and the healthy peopleas a control group.RESULTS:In the control group,no people were de-tected to have Hpylori in the pharynx.In contrast,in 50cases with chronic pharyngitis,19(38.0%)cases wereH pyIori positive with a TDI-FP assay and 4(8%)caseswere TDI-FP positive with Giemsa staining in the phar-ynx.Sixteen of the 50 pharyngitis cases had stomachailment history,11 cases(68.8%)of these 16 patientswere determined to be H pylori positive in the pharynxwith the TDI-FP assay.x^2 test showed that this infectionrate was remarkably higher(P=0.0007)than that in thecases without stomach ailment history.Giemsa stainingshowed that 3 cases(18.8%)of the patients with stom-ach ailment history were infected with H pylori in the pharynx,which was remarkably higher(P=0.042)thanthat in the patients without stomach ailment history(1case,which was 2.9%).CONCLUSION:H pylori may not be detected in thepharynx of healthy people.Chronic pharyngitis maybe related to H pylori infection.The infection rate withHpylori in the pharynx is higher in patients with stomachailment histories than in patients without stomach ail-ment histories,suggesting that chronic pharyngitis maybe related to stomach ailment history. | Jiang-Ping Zhang Zhen-Hui Peng Ju Zhang Xiang-Hong Zhang Qing Yin Zheng | 2006 | World Journal of Gastroenterology2006，12，3： | 6 |
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