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95篇 您的检索式:作者名="Penaranda"
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1Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process.Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière 2016World Journal of Hepatology2016,8,17:7
2Recommendations for the use of chemoembolization in patients with hepatocellular carcinoma: Usefulness of scoring system?显示文摘Several hepatocellular carcinoma(HCC) staging systems have been established, and a variety of countryspecific treatment strategies are also proposed. The barcelona- clinic liver cancer(BCLC) system is the most widely used in Europe. The Hong Kong liverCancer is a new prognostic staging system; it might become the reference system in Asia. Transarterial chemoembolization(TACE) is the most widely used treatment for HCC worldwide; but it showed a benefit only for intermediate stage HCC(BCLC B), and there is still no consensus concerning treatment methods and treatment strategies. In view of the highly diverse nature of HCC and practices, a scoring system designed to assist with decision making before the first TACE is performed or prior to repeating the procedure would be highly useful.Xavier Adhoute Guillaume Penaranda Paul Castellani Herve Perrier Marc Bourliere 2015World Journal of Hepatology2015,7,3:6
3Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction 显示文摘Tang Q Adams J Y Penaranda C 2008Immunity2008,28,:1
4Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preser- ving regulatory T cells显示文摘Penaranda C Tang Q Bluestone JA 2011J Immunol2011,187,4:1
5Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardiac hyporesponsiveness to catecholamines显示文摘Silverman HJ Penaranda R Orens JB 1993Crit Care Med1993,21,1:1
6Add-on of peg interferon to a stable nucleoside regimen led to loss of HbsAg in chronic hepatitis HBeAg negative patients显示文摘Ouzan D Penaranda G Joly H 0,,1:1
7Complete genome sequences of all members of the species Human entereovirus A 显示文摘OBERSTE M PENARANDA S S MAHER K 2004J C en Virol2004,85,6:1
8Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction显示文摘Tang Q Adams JY Penaranda C 2008Immunity2008,28,5:1
9Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus 显示文摘HALFON P BOURLIERE M PENARANDA G 2005Comp Hepatol2005,4,6:1
10Diversity ofpicomavirus^ in rural Bolivia显示文摘NIX W A KHETSURIANI N PENARANDA S et ai 2013J Gen Virol2013,94,9:1
11Complete genome sequences of all members of the species Human enterovirus A显示文摘Oberste MS Penaranda S Maher K 2004Journal of General Virology2004,85,:1
12Compara- tive evaluation of Taqman real-time PCR and semi-nested VP1 PCR for detection of enteroviruses in clinical speci- mens显示文摘Oberste M S Penaranda S Rogers S L 2010J Clin Virol2010,49,1:1
13Complete genome sequences of all members of the species human enterovirus A显示文摘Oberste M S Penaranda S Maher K 2004J Gen Virol2004,85,6:1
14Optimized stepwise combination algorithms of non - invasive liver fibrosis scores including Hepascore in hepatitis C virus patients 显示文摘Bourliere M Penaranda G Ouzan D 2008Aliment Pharmacol Ther2008,28,4:1
15Nordihydroguai- arctic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/ nen receptors and suppresses growth in breast cancer cells显示文摘Youngren JF Gable K Penaranda C 2005Breast Cancer Res Tr2005,94,28:1
16Diarylureas are small molecule inhibitors of insulin-like growth factor I recep- tor signaling and breast cancer cell growth显示文摘Gable KL Maddux BA Penaranda C et aI 2006Mol Cancer T- her2006,5,19:1
17Compara- tive evaluation of Taqman real-time PCR and semi-nes- ted VP1 PCR for detection of enteroviruses in clinical specimens显示文摘Oberste M S Penaranda S Rogers S L 2010J Clin Virol2010,49,1:1
18Complete genome sequences of all nembers of all members of species human enterovirus A 显示文摘Oberste MS Penaranda S Maher K 2004J Gen Virol2004,85,6:1
19Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction显示文摘Tang Q Adams JY Penaranda C 0,,05:1
20Add-on peg-interferon leads to loss of HBsAg in patients with HBeAg-negative chronic hepatitis and HBV DNA fully suppressed by long-term nucleotide analogs显示文摘Ouzan D Penaranda G Joly H 2013J Clin Virol2013,58,4:1
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