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| 1 | Heterogeneous populations of neural stem cells contribute to myelin repair显示文摘As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis(MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demonstrated the increasing inability of oligodendrocyte precursor cells(OPCs) to replace lost oligodendrocytes(OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair. | Rainer Akkermann Felix Beyer Patrick Küry | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 2 | Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients显示文摘 | Fran?ois Blot Thomas Similowski Jean-Louis Trouillet Patrick Chardon Jean-Michel Korach Marie-Alyette Costa Didier Journois Guillaume Thiéry Muriel Fartoukh Isabelle Pipien Nicolas Bruder David Orlikowski Frédéric Tankere Isabelle Durand-Zaleski Christian | 2008 | Intensive Care Medicine2008，，10： | 1 |
| 3 | SDF-1 stimulates neurite growth on inhibitory CNS myelin显示文摘 | Jessica Opatz Patrick Küry | 2009 | Molecul Cell Neurosc2009，40，： | 1 |
| 4 | Laparoscopic Partial Splenectomy: Indications and results of a multicenter retrospective study显示文摘 | Géraldine Héry Fran?ois Becmeur Laure Méfat David Kalfa Patrick Lutz Laurence Lutz Jean-Michel Guys Pascal Lagausie | 2008 | Surgical Endoscopy2008，，1： | 1 |
| 5 | 5-Lipoxygenase inhibitoryactivity of zileuton显示文摘 | George WC Patrick RY Daniel HA | 1991 | J Pharmacol Exp Ther1991，256，3： | 1 |
| 6 | First detection of Israeli acute paralysis virus (IAPV) in France, a dicistrovirus affecting honeybees ( Apis mellifera )显示文摘 | Philippe Blanchard Frank Schurr Olivier Celle Nicolas Cougoule Patrick Drajnudel Richard Thiéry Jean-Paul Faucon Magali Ribière | 2008 | Journal of Invertebrate Pathology2008，，3： | 1 |
| 7 | Novel approaches for the development of peripheral nerve regenerative therapies显示文摘Schwann cells are the myelinating glial cells of the peripheral nervous system(PNS).By establishing lipid-rich myelin sheaths around large-caliber axons,they ensure that electrical signal transmission is accelerated–a process referred to as saltatory signal propagation.Apart from this prominent physiological function,these cells also | Felix Beyer Patrick Küry | 2015 | Neural Regeneration Research2015，10，11： | 0 |
| 8 | Human endogenous retroviruses: ammunition for myeloid cells in neurodegenerative diseases?显示文摘Activation of myeloid cells by human endogenous retroviral entities:While the exact causes of neurological diseases such as multiple sclerosis(MS)or amyotrophic lateral sclerosis(ALS)are still elusive,there is evidence of a new category of pathogenic elements called human endogenous retroviruses(HERVs)which seem to contribute to their evolution and progression by exerting inflammatory and degenerative effects(Kury et al.,2018).HERVs are ancient retroviral elements which account for up to 8%of the human genome and it is known that environmental factors can trigger their(re-)expression(Kury et al.,2018).The resulting production of viral particles and/or proteins,especially from members of the HERV-W and HERV-K family,is strongly correlated with the onset and progression of neurological diseases,such as MS and ALS(Kury et al.,2018). | Joel Gruchot David Kremer Patrick Küry | 2020 | Neural Regeneration Research2020，15，6： | 0 |
| 9 | A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France显示文摘Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global climate.In September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(Loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS satellite.Based on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were characterized.Significant increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air quality.Emission factors,defined as EF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous studies.Changes in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and discussed.Moreover,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and BC)emissions and compared them with fire emission inventories.Current biomass burning emission inventories have uncertainties in estimating small fire burned areas and emissions.For instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFED and FINN)showed significant overestimation.Considering that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed. | Chaoyang Xue Gisèle Krysztofiak Yangang Ren Min Cai Patrick Mercier Frédéric Le Fur Corinne Robin Benoit Grosselin Véronique Daele Max RMcGillen Yujing Mu Valéry Catoire Abdelwahid Mellouki | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 10 | Multiple sclerosis drug repurposing for neuroregeneration显示文摘Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all phenotypes.Autoimmune-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(Kuhlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1). | Peter Göttle Michael Dietrich Patrick Küry | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 11 | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis显示文摘Astrocytes are indispensable for central nervous system development and homeostasis.In response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair response.In this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models.We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination.Finally,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response. | Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 12 | Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors显示文摘The role of adult neural stem cells(NSCs)in demyelinating diseases of the central nervous system(CNS):Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS.Originating from radial glial cells during nervous system development,adult NSCs are localized in the subgranular zone of the hippocampus and the subventricular zone(SVZ)of the lateral brain ventricles,the main neurogenic zones of the adult brain.Hippocampal precursor cells(type 1 cells)exhibiting properties of radial glial cells give rise to granule neurons through distinct intermediate precursor cells,and integrate into the hippocampal circuitry[reviewed by Kempermann et al.(2015)].Likewise,under physiological conditions,neuron generation by mouse SVZ-derived NSCs(also known as type B cells)is the predominant cell fate,which thereby results in large numbers of transient amplifying precursor cells(also known as type C cells)which in turn differentiate into neuroblasts(type A cells).These cells migrate along the rostral migratory stream into the olfactory bulb where they undergo maturation into local interneurons.The structure of the rodent SVZ differs from that of the human SVZ since the proliferative capacity is reduced,and migration of neuroblasts is a rare event in adult humans[reviewed by Lim and Alvarez-Buylla(2016)]. | Jessica Schira-Heinen Iria Samper Agrelo Veronica Estrada Patrick Küry | 2022 | Neural Regeneration Research2022，17，10： | 0 |
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