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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | An automated inspection station for machine-vision grading of potatoes显示文摘 | Paul H. Heinemann Niranjan P. Pathare Charles T. Morrow | 1996 | Machine Vision and Applications1996，，： | 1 |
| 3 | Mathematical modeling of infrared raliation thin layer drying of onion slices显示文摘 | Sharma GP Verma RC Pathare P | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 4 | Fatty acids derived from a marine crustacean Diogenes avarus (Heller) and their antiangiogenic activity显示文摘 | Pathare S Indap M | 2003 | Indian J Exp Biol2003，41，6： | 1 |
| 5 | The interaction be- tween leading and trailing limbs during stopping in humans 显示文摘 | Bishop MD Brunt D Pathare N | 2002 | Neurosci Lett2002，323，1： | 1 |
| 6 | Combined therapy with desferrioxamine and deferiprone in beta thalassemia major patients with transfusional iorn Overload显示文摘 | Daar S Pathare AV | 2006 | Ann Hematol2006，85，5： | 1 |
| 7 | Thin-layer infrared radiation drying of onion slices显示文摘 | Sharma G P Verma P C Pathare P B | 2005 | Journal of Food Engineering2005，67，2： | 1 |
| 8 | Study the drying kinetics of open sun drying of fish显示文摘 | Jain D Pathare P B | 2007 | J Food Engineering2007，78，4： | 1 |
| 9 | Automotive Roof Crush, Structural Foam Enhancement Solution显示文摘 | PATHARE R MANSOUR M | 2009 | SAE2009，01，： | 1 |
| 10 | Thin-layer infrared radiation drying of onion slices显示文摘 | G.P. Sharma R.C. Verma P.B. Pathare | 2004 | Journal of Food Engineering2004，，3： | 1 |
| 11 | Polyenpsulated Dry Film Paint Preservative显示文摘 | Prakash Pathare Helmut Unkel | 2005 | Coatings Technology & Abstracts2005，30，8： | 1 |
| 12 | Development of mathematical model for cooling the fish with ice显示文摘 | JAIN D ILYAS S M PATHARE P | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 13 | Study the drying kinetics of open sun drying of fish显示文摘 | Dilip Jain Pankaj B Pathare | 2007 | J Food Engineering2007，78，： | 1 |
| 14 | Mathematical modeling of infrared radiation thin layer drying of onion slices显示文摘 | SHARMA G P VERMA R C PATHARE P | 2005 | Journal of Food Engineering2005，71，3： | 1 |
| 15 | Thin - layer infrared Radiation drying of onion slices 显示文摘 | Sharma G P Verma P C P B Pathare | 2005 | Journal of Food Engineering2005，67，2： | 1 |
| 16 | Mathematical modeling of infrared radiation thin layer drying of onion slices显示文摘 | Sharma G P Verma R C Pathare P | 2005 | Journal of Food Engineering2005，71，3： | 1 |
| 17 | An auto- mated inspection station for machine-vision grading of potatoes 显示文摘 | aul H Heinemann Niranjan P Pathare Charles T Morrow | 1996 | Ma- chine Vision and Applications1996，9，1： | 1 |
| 18 | 多组分微胶囊涂料干膜防霉杀菌剂显示文摘本报告曾在2005年德国柏林召开的“欧洲涂料会议”上发表,引起广泛的关注。提出了一种在涂料中高效使用目前杀菌剂的一种新的技术思路及方法,在此推荐给大家,供我国同仁们借鉴和参考。 | Prakash Pathare Helmut Unkel 钱伯容(编译) | 2006 | 涂料技术与文摘2006，27，7： | 1 |
| 19 | Surgery in haemophilia: experience from a centre in India显示文摘 | Ghosh K Jijina F Pathare AV | 1998 | Haemophilia1998，4，2： | 1 |
| 20 | Design of packaging vents for cooling fresh horticultural produce显示文摘 | Pathare P B Opara U L Vigneault C | 2012 | Food and B ioprocess Technology2012，5，6： | 1 |
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