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| 1 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 2 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 3 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 4 | On the GI/M/1/N queue with working vacations-analytic analysis and computation显示文摘 | Banik A D Gupta U C Pathak S S | 2007 | Applied Mathematics Modeling2007，，： | 1 |
| 5 | Empirical analysis of the impact of recommender systems on sales显示文摘 | Pathak B Garfinkel R Gopal R D | 2010 | Journal of Management Information Systems2010，27，2： | 1 |
| 6 | Efficacy, safety and treatment satisfaction of Glimepiride vs Sitagliptin in combination with Metformin in type 2 diabetes mellitus 显示文摘 | Kumar S Pathak AK Saikia D | 2015 | Journal of Clinical & Diagnostic Research Jcdr2015，9，12： | 1 |
| 7 | A comparative study on parthenogenetic activation and embryo production from in vitro matured caprine oocytes显示文摘 | Pathak J Kharche S D Goel A K | 2013 | Small Ruminant Research2013，113，： | 1 |
| 8 | Empirical modeling of chemoviscosity of hydroxy terminated polybutadiene based solid composite propellant slurry显示文摘 | Mahanta Abhay K Goyal Monika Pathak Devendra D | 2010 | Malaysian Polymer Journal2010，5，1： | 1 |
| 9 | Perceived harriers lo medical - error re- porting: an exploratory investigation 显示文摘 | Uribe C Schweikhart S Pathak D | 2002 | J Healthc Manag2002，47，： | 1 |
| 10 | Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype显示文摘 | Pathak AP Artemov D Neeman M | 2006 | Cancer Res2006，66，10： | 1 |
| 11 | Effect of Heating Rates on the Synthesis of Al2 O3-SiC Com posites by the Self-Propagating High-Temperature Syn- thesis (SHS) Technique显示文摘 | Pathak L C Bandyopadhyay D Srikanth S | 2001 | Journal of the American Ce- ramic Society2001，84，2： | 1 |
| 12 | A study oneffect of mineral additions on the mechanical, thermal, and structuralproperties of poly ( butylene terephthalate) ( PBT) composites 显示文摘 | DESHMUKH G S PESHWE D R PATHAK S U | 2011 | Journal of Polymer Research2011，18，5： | 1 |
| 13 | Effect of new hyperbranched polyester of varying generations on toughening of epoxy resin through interpenetrating polymer networks using urethane linkages显示文摘 | D Manjula Dhevi S N Jaisankar Madhvesh Pathak | 2013 | European Polymer Journal2013，49，11： | 1 |
| 14 | Change In chemical composition and in sacco degradability of wheat straw treated with pleurotus sajorcaju and postreatus显示文摘 | Dintaran P Kamra D N Pathak N N | 1999 | International Journal of Animal Science1999，14，1： | 1 |
| 15 | Use of Flyash and Biogas Slurry for Improving Wheat Yield and Physical Properties of Soil显示文摘 | Garg R N Pathak H Das D K | 2005 | Environmental Monitoring and Assessment2005，107，13： | 1 |
| 16 | Application of ozone based treatments of secondary effluents显示文摘 | Tripathi S Pathak V Tripathi D M | 2011 | Bioresource Technology2011，102，3： | 1 |
| 17 | Synergistic inhibition of the calcification of glutaraldehyde pretreated bovine pericardium in a rat subdermal model by FeCI, and ethanehydroxydiphosphonate: preincubation and polymeric controlled release studies显示文摘 | Hirsch D Drader J Pathak YV | 1993 | Biomaterials1993，14，9： | 1 |
| 18 | Developing instruments for cross-cultural psychiatric research显示文摘 | Flaherty JA Gaviria FM Pathak D | 1988 | Journal of Nervous and Mental Disease1988，176，5： | 1 |
| 19 | Effect of new hyperbranehed polyester of varying generations on toughening of epoxy resin through interpenetrating poly- mer networks using urethane linkages 显示文摘 | Manjula Dhevi D Jaisankar S N Pathak M | 2013 | European Polymer Journal2013，，： | 1 |
| 20 | Some fixed point theorems in metrically convex spaces显示文摘 | Pathak H K Khan M D | 2000 | Georgian J Math2000，7，： | 1 |
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