|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Takotsubo cardiomyopathy:A comprehensive review显示文摘Takotsubo cardiomyopathy(TCM),also known as stress cardiomyopathy,occurs in the setting of catecholamine surge from an acute stressor.This cardiomyopathy mimics acute myocardial infarction in the absence of coronary disease.The classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left ventricle.The etiology of the stressor is often physical or emotional stress,however iatrogenic causes of TCM have been reported in the literature.In our review,we discuss medications,primarily the exogenous administration of catecholamines,and a wide array of procedures with subsequent development of iatrogenic cardiomyopathy.TCM is unique in that it is transient and has favorable outcomes in most individuals.Classically,beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy;however,unique to TCM,no specific treatment is required other than temporary supportive measures as this process is transient.Additionally,no improvement in mortality or recurrence have been reported in patients on these drugs.The aim of this review is to elucidate on the iatrogenic causes of TCM,allowing for prompt recognition and management by clinicians. | Walker Barmore Himax Patel Sean Harrell Daniel Garcia Joe B Calkins Jr | 2022 | World Journal of Cardiology2022，14，6： | 2 |
| 3 | Antimicrobial resistant pathogens associated healthcare-associated infections: annual summary of date reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007显示文摘 | HidronAI Edwards JR Patel J | 2008 | Infect Control Hosp Epidemiol2008，29，11： | 1 |
| 4 | Definitive chemoradiotherapy for non-small cell lung cancer with N2 disease显示文摘 | Patel S Sanbom RE Thomas CR Jr | | 0，，04： | 1 |
| 5 | A Novel Ap- proach To Investigate the Uptake and Internalization of Escherieh- ia coli O157:H7 in Spinach Cultivated in Soil and Hydroponic Medium显示文摘 | Sharma M Ingrain DT Patel JR | 2009 | Journal of Food Protection2009，72，7： | 1 |
| 6 | Evaluation and treatment of spinal injuries in the patient with polytrauma显示文摘 | Patel RV Delong Jr W Vresilovic EJ | 2004 | Clin Orthop2004，422，： | 1 |
| 7 | Experience with keloids after excision and application of 5% imiquimod cream显示文摘 | Patel PJ Skinner RB Jr | 2006 | Dermatol Surg2006，32，3： | 1 |
| 8 | Antimicrobial - Resistant Pathogens Associated With Heahhcare- Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006 - 2007显示文摘 | Hidron AI Edwards JR Patel J | 2008 | Infect Control Hosp Epidemiol2008，29，： | 1 |
| 9 | Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shorten hospital stay in patients undergoing radical retropubic prostatectomy显示文摘 | Fischer HA Kaufman RP Jr Patel MK Wilkins LJ Mehta SA | 1998 | Anesth Analg1998，86，2： | 1 |
| 10 | Regulation of immune activity by mild (fever-range) whole boty hyperthermia: effects on epidermal Langerhans cells显示文摘 | Ostberg JR Patel R Repasky EA | 2000 | Cell Stress Chaperones2000，5，5： | 1 |
| 11 | Brow-lift suhgaleal vs subpe riosteal flap adherence in the rabbit model显示文摘 | Thomas JR Lee AS Patel AB | 2007 | Arch Facial Plast Surg2007，9，2： | 1 |
| 12 | High efficiency nondispersive reactor for two-phase reactions 显示文摘 | Jr Massingill J L Patel P N Guntupalli M | 2008 | Organic Process Research Development2008，12，4： | 1 |
| 13 | Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus:a randomized controlled trial显示文摘 | Beulens JW Patel A Vingerling JR | 2009 | Diabetologia2009，52，10： | 1 |
| 14 | DNA sequence variation within vanA, vanB, vanC-1 ,and vanC-2/3 genes of clinical Enterococcus isolates显示文摘 | Patel R Uhl JR Kohner P | 1998 | Antimicrob Agents Chemoth- er1998，42，1： | 1 |
| 15 | Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid 显示文摘 | Patel JR Brewer GJ | 2008 | J Neurosci Res2008，86，10： | 1 |
| 16 | NHSN annual update:antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to theNational Healthcare Safety Network at the Centers for DiseaseControl and Prevention, 2006-2007显示文摘 | Hidron Al Edwards JR Patel J | 2008 | Infect Control HospEpidemiol2008，29，11： | 1 |
| 17 | Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta显示文摘 | Patel SA Meyer JR Greco SJ | 2010 | J Immunol2010，184，10： | 1 |
| 18 | Fiber orientation in the canine left ventricle during diastole and systole显示文摘 | Streeter DD Jr Spotnitz HM Patel DP | | 0，，03： | 1 |
| 19 | Risk factors and consequences of delayed graft function in deceased donor renal transplant patients receiving antithymocyte globulin induction显示文摘 | Patel SJ Duhart BT Jr Krauss AG | 2008 | Transplantation2008，86，2： | 1 |
| 20 | Thoracicaortic endovascular repair for mycotic aneurysms andfistulas显示文摘 | Patel HJ Williams DM Upchurch GR Jr | 2010 | J Vase Surg2010，52，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员