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| 1 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 2 | 城市分区与土地规划:打造美国的大型都市显示文摘文章主要讨论了美国传统的城市分区机制——Euclidean分区机制的演变及原因。Euclidean分区的概念,简单地说是指,根据固定的法律条文,将城市划分为“不可兼容”的不同功能区域。然而,由于城市功能日趋复杂化,特殊区域的特定管理,以及针对土地用途管理和后果所作的可行性审查等方面的原因,这一传统概念正逐步被淘汰。本文将着重分析这些变化,并讨论特殊区域划分——一种特定地区发展控制手段——的使用性及有效性。 | Edward H.Ziegler Jr 周雪 | 2005 | 国外城市规划2005，20，3： | 16 |
| 3 | 子宫颈癌筛查异常妇女处理的共识指南(2006版)显示文摘2001年,美国阴道镜与宫颈病理学会(American Society for Colposcopyand Cervical Pathology,ASCCP)联合其他专业学会以及联邦与国际组织.制订了2001版的宫颈癌细胞学筛查结果异常妇女处理的共识指南。这是全面的、以循证医学为依据的指南,其目的是帮助所有亚专业的临床医生,处理每年约480万诊断为细胞学异常的美国妇女。 | 李志刚(翻译) Thomas C. Wright Jr L Stewart Massad Charles J. Dunton MarkSpitzer Edward J. Wilkinson DianeSolomon | 2008 | 循证医学2008，8，4： | 16 |
| 4 | 利用直接推进技术测定渗透系数的最新进展显示文摘高精度测定渗透系数(K)的重要性不言自明,但是现阶段野外试验手段能够提供的关于K的信息不能满足高度非均质地层中污染物迁移预测模拟的需求。直接推进注入记录器(Direct-Push Injection Logger,DPIL)和直接推进渗透仪(Direct-Push Permeameter,DPP)是新发展的水文地质参数测量仪器,能够使K值的测定达到前所未有的分辨率和成本效益水平。工具向地下推进过程中,通过对注水量、注水压力和其它的水文地球物理参数的同步监测,直接推进技术(Direct Push,DP)能快捷准确地获得地层渗透系数的垂向分布。DP技术几乎适用于所有野外松散地层,并且对场地的干扰很小。因此,它克服了许多基于既有井的传统含水层测试方法的局限性。最近在美国MADE试验场的一个案例研究表明,使用DPIL/DPP可以获得空间分辨率达1.5cm的K值垂向分布。未来,高精度直接推进技术还可以与新一代的地球物理技术,例如高精度探地雷达相结合,以实现不同位置DP测定K值的互联以及整个试验场K值三维分布的确定。 | 王晓丽 郑春苗 刘改胜 李文鹏 Steve Knobbe Edward Reboulet James J.Butler Jr | 2012 | 水文地质工程地质2012，39，1： | 9 |
| 5 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 6 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 7 | Nosocomial infections in comvined medical-surgical intensive care unirs in the Uniteol states 显示文摘 | Ridards MJ Edwards JR Cuwer DH | 2000 | Infect Conerol Hosp Epidemiol2000，21，8： | 2 |
| 8 | Antimicrobial-re- sistant pathogens associated with healthcare-associated infec- tions: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Preven- tion, 2009- 2010显示文摘 | Sievert DM Ricks P Edwards JR | 2013 | Infect Control Hosp Epidemiol2013，34，1： | 1 |
| 9 | Use of bone scintigraphy to select patients with multiple myeloma for treatment with strontium-89显示文摘 | Edwards GK Santoro J Taylor A Jr | 1994 | JNuel Med1994，35，12： | 1 |
| 10 | Reducing the Economic Burden of HPV-Related Diseases 显示文摘 | Edward John Mayeaux Jr MD | 2008 | J Am Osteopath Assoc2008，108，2： | 1 |
| 11 | Antimicrobial resistant pathogens associated healthcare-associated infections: annual summary of date reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007显示文摘 | HidronAI Edwards JR Patel J | 2008 | Infect Control Hosp Epidemiol2008，29，11： | 1 |
| 12 | National Healthcare Safety Network(NHSN)report:data summary for 2006through 2008,issued December 2009显示文摘 | Edwards JR Peterson KD Mu Y | 2009 | Am J Infect Control2009，37，10： | 1 |
| 13 | Studies on tile biotin requirement of broiler breeders 显示文摘 | Brewer I E Edwards It M Jr | 1972 | Poultry Sci1972，51，： | 1 |
| 14 | Results of medial patellofemoral ligament reconstruction in the treatment of patellar dislocation显示文摘 | Drez D Jr Edwards T B Williams C S | 2001 | Arthroscopy2001，17，3： | 1 |
| 15 | Mice with disseminated candidiasis die of progressive sepsis 显示文摘 | Spellberg B lbrahim AS Edwards JE Jr | 2005 | J Infect Dia2005，192，2： | 1 |
| 16 | An Association Analysis of Alzheimer Disease Candidate Genes Detects an Ancestral Risk Haplotype Clade in ACE and Putative Multilocus Association between ACE,A2M,and LRRTM3显示文摘 | Edwards TL Pericak-Vance M Gilbert JR | 2009 | Am J Med Genet B Neuropsychiatr Genet(S1552-4841)2009，150，5： | 1 |
| 17 | NHSN annual update: antimicrobial-resistant pathogens associated with healthcare- associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007显示文摘 | Hidron AI Edwards JR Pate1 J | 2008 | Infect Control Hosp Epidemiol2008，29，11： | 1 |
| 18 | Research in stress,coping and health-Theoretical and methodological issues 显示文摘 | Edwards JR Cooper CL | 1988 | Psychological Medicine1988，，18： | 1 |
| 19 | National Health- care Safety Network (NHSN) report: datasummary for 2006 through 2008,issue December 2009显示文摘 | Edwards JR Peterson KD MU Y | 2009 | Ami Infect Control2009，37，10： | 1 |
| 20 | Trends in incidence of late-onset methicillin-resistant Staphylococcus aureus infection in neonatal intensive care units: data from the National Nosocomial Infections Surveillance System, 1995-2004显示文摘 | Lessa FC Edwards JR Fridkin SK Tenover FC Horan TC Gorwitz RJ | 2009 | Pediatr Infect Dis J2009，28，7： | 1 |
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