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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | The efficacy of hypert0nic saline nasal irrigation for chronic sinonasal symptoms 显示文摘 | Rabago D Pasic T Zgierska A | 2005 | Otolar- yngol Head Neck Surg2005，133，1： | 1 |
| 3 | Treatment of vitiligo withnarrow-band UVB and topical gel containing catalase andsuperoxide dismutase 显示文摘 | Kostovic K Pastar Z Pasic A | 2007 | Acta Dermatovenerol Croat2007，15，1： | 1 |
| 4 | The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms显示文摘 | Rabago D Pasic T Zgierska A | 2005 | Otolaryngol Head Neck Surg2005，133，1： | 1 |
| 5 | New trends in the immunopathogenesis of psoriasis 显示文摘 | Kastelan M Massari LP Pasic A Gruber F | 2004 | Acta Dermatovenerol Croat2004，12，1： | 1 |
| 6 | New trends in the immune pathogenesisof psoriasis显示文摘 | KsatelanM Massari LP Pasic A | 2004 | Acta Dermatoven2 erol Croat2004，，12： | 1 |
| 7 | New trends in the immunopa thogenesis of psoriasis 显示文摘 | Kastelan M Massari LP Pasic A | 2004 | Acta Dermatovenerol Croat2004，12，1： | 1 |
| 8 | New trends in the immunopathogenesis of psoriasis显示文摘 | Kastelan M Massari LP Pasic A | 2004 | Acta DermatovenerolCroat2004，12，1： | 1 |
| 9 | Combined elective percutaneous coronary intervention and transapical transcatheter aortic valve implantation显示文摘 | Pasic M Dreysse S Unbehaun A | | 0，，： | 1 |
| 10 | Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients 显示文摘 | PASIC A VONK-NOORDEGRAAF A RISSE E K | 2003 | Lung Cancer2003，41，3： | 1 |
| 11 | Observational comparison of abdominal,vaginal and laparoscopic hysterectomy as performed at a university teaching hospital显示文摘 | Abdelmonem A Wilson H Pasic R | 2006 | J Reprod Med2006，51，12： | 1 |
| 12 | New treatment modalities for vitiligo:focus on topical immunomodulators显示文摘 | Kostovic K Pasic A | 2005 | Drugs2005，65，4： | 1 |
| 13 | Coexistence of psoriasis vulgaris,bullous pemphigoid and vitiligo:a case report显示文摘 | Pasic A Ljubojevic S Lipozencic J | 2002 | J Eur Acad Dermatol Venereol2002，16，4： | 1 |
| 14 | Folliculotropic mycosis fungoides with follicular mucinosis-case report显示文摘 | Rados J Dobric' I Pasic' A | 2006 | Acta Dermatovenerol Croat2006，14，2： | 1 |
| 15 | Observational comparison of abdominal, vaginal and laparoscopic hysterectomy as performed at a university teaching hospital显示文摘 | Abdelmonem A Wilson H Pasic R | 2006 | J Reprod Med2006，51，12： | 1 |
| 16 | High prevalence of testicular adrenal rest tumors, impaired spermatogenesis and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia显示文摘 | Stikkelbroeck NM Otten BJ Pasic A | 2001 | J Clin Endocrinol Metab2001，86，12： | 1 |
| 17 | Observational comparison of abdominal,vaninal and laparoscopic hysterectomy as performed at a university teaching hospital显示文摘 | Abdelmonem A Wilson H Pasic R | 2006 | J Reprod Med2006，51，12： | 1 |
| 18 | Observational comparison of abdominal,vaginal and laparoscopic hysterectomy as performed at a university teaching hospital显示文摘 | Abdelmonem A Wilson H Pasic R | 2006 | J Reprod Med2006，51，12： | 1 |
| 19 | Observational comparison of abdominal vaginal and Iaparoscopic hysterectomy as performed at a university teachin: hosoital显示文摘 | Abdelmonem A Wilson H Pasic R | 2006 | J Reprod Med2006，51，12： | 1 |
| 20 | New trends in the immunopathogenesis of psoriasis显示文摘 | Kastelan M Massari LP Pasic A | | 0，，01： | 1 |
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