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| 1 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 2 | Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling显示文摘We summarize from previous works the functions of circular vs. longitudinal muscle in esophageal peristaltic bolus transport using a mix of experimental data, the conservation laws of mechanics and mathematical modeling. Whereas circular muscle tone generates radial closure pressure to create a local peristaltic closure wave, longitudinal muscle tone has two functions, one physiological with mechanical implications, and one purely mechanical. Each of these functions independently reduces the tension of individual circular muscle fibers to maintain closure as a consequence of shortening of longitudinal muscle locally coordinated with increasing circular muscle tone. The physiological function is deduced by combining basic laws of mechanics with concurrent measurements of intraluminal pressure from manometry, and changes in cross sectional muscle area from endoluminal ultrasound from which local longitudinal shortening (LLS) can be accurately obtained. The purely mechanical function of LLS was discovered from mathematical modeling of peristaltic esophageal transport with the axial wall motion generated by LLS. Physiologically, LLS concentrates circular muscle fibers where closure pressure is highest. However, the mechanical function of LLS is to reduce the level of pressure required to maintain closure. The combined physiological and mechanical consequences of LLS are to reduce circular muscle fiber tension and power by as much as 1/10 what would be requiredfor peristalsis without the longitudinal muscle layer, a tremendous benefit that may explain the existence of longitudinal muscle fiber in the gut. We also review what is understood of the role of longitudinal muscle in esophageal emptying, reflux and pathology. | James G Brasseur Mark A Nicosia Anupam Pal Larry S Miller | 2007 | World Journal of Gastroenterology2007，13，9： | 4 |
| 3 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 4 | Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats显示文摘瞄准:为了是学习 N-acetylcysteine (NAC ) 的角色,在 rifampicin (RMP ) 的一个保护的代理人导致了小老鼠的氧化肝的损害。方法:肝的损害被为 3 wk 给 RMP 的 50 mg/kg 体重生产。NAC (100 mg/kg 体重) 的剂量 intraperitoneally 与 RMP 在联合被给。类脂化合物的分析与体重,肝重量和组织学的观察一起在肝每氧化,巯基层次,细胞色素 P450,超级氧化物歧化酶(草皮) ,过氧化氢酶,谷胱甘肽过氧化物酶,还原酶和转移酶被估计。结果:当抗氧化的酶被改变时, RMP 暴露在身体和肝重量导致了没有变化但是非,蛋白质巯基(GSH ) 地位很好被保存。细胞色素 P450 系统并且每类脂化合物的氧化被 RMP 暴露导致。部分保护在肝对导致 RMP 的变化与 NAC 被观察,它在草皮和过氧化氢酶酶层次每氧化和减小从类脂化合物的增加的预防被证实。结论:NAC 保护小老鼠免于导致 RMP 的氧化肝的损害。 | SV Rana S Attri K Vaiphei R Pal A Attri K Singh | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 5 | High-pressure synthesis and characterization of diamond from a sulfur–carbon system显示文摘 | Yu Pal’yanov Yu Borzdov I Kupriyanov V Gusev A Khokhryakov A Sokol | 2001 | Diamond & Related Materials2001，，： | 2 |
| 6 | Image enhancement and thresholding by optimization of fuzzy compactness显示文摘 | Pal S K Rosenfeld A | 1988 | Pattern Recognition Letters1988，7，1： | 2 |
| 7 | Strain-independen temperature measurement using a type-land type - ⅡA optical fiber Bragg grating combination显示文摘 | S Pal T Sun K T V Grattan S A Wade S F Collins G W Baxter B Dussardier and G Monnom | 2004 | Rev Sci Instrum2004，75，： | 1 |
| 8 | Propagating extrusion tectonics in sia: New insights from simple experiments with plasticine显示文摘 | Tapponnier P G Pal Tzer A Y Ledain | 1982 | Geology1982，10，： | 1 |
| 9 | On edge detection of X -ray images using fuzzy sets显示文摘 | PAL S K KING R A | 1983 | IEEE Trans Part Analand Machine Intell1983，5，1： | 1 |
| 10 | Effects of trochanteric soft tissue thickness and hip impact velocity on hip fracture in sideways fall through 3 D finite element simulations 显示文摘 | Majumder S Roychowdhury A Pal S | 2008 | J Biomechanics2008，41，： | 1 |
| 11 | The Parkinson’s diseasesleep scale:a new instrument for assessing sleep and nocturnaldisability in Parkinson’s disease显示文摘 | Chaudhuri KR Pal S DiMarco A et a1 | 2002 | J Neurol Neurosuig Psychiatry2002，73，： | 1 |
| 12 | Characterization of a novel dentin matrix phosphoprotein显示文摘 | George A Sabasy B Simonian PAL | 1993 | J Biol Chem1993，268，12： | 1 |
| 13 | Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer显示文摘 | Pal A Ahmad A Khan S | 2005 | Int J Oncol2005，26，4： | 1 |
| 14 | The Parkinson's disease sleep scale:a new instrument for assessing sleep and nocturnal disability in Parkinson's disease显示文摘 | Chaudhuri KR Pal S DiMarco A | 2002 | J Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 15 | Image enhancement using smoothing with fuzzy sets显示文摘 | PAL S K KING R A | 1981 | IEEE Transactions on System Man and Cybermetics1981，11，7： | 1 |
| 16 | In vitro regeneration of Stevia rebaudiana (Bert) from the nodal explant显示文摘 | Mitra A Pal A | 2007 | Journal of plant Biochemistry and Biotechnology2007，16，1： | 1 |
| 17 | Recommendation of adjuvant chemotherapy and trastuzumab in older adults with HER2-positive breast cancer:A survey of oncologists显示文摘 | Pal SK Naeim A Wong FL | | 0，，15： | 1 |
| 18 | Bacterial vagiosis and other vaginal infections显示文摘 | Pal Z Dosa E Pal A | | 0，，： | 1 |
| 19 | Identification of genes involved in bamboo fiber development显示文摘 | Rai V Ghosh J S Pal A | | 0，，1： | 1 |
| 20 | Effective focused crawling based on content and link structure analysis 显示文摘 | Pal A Tomar D S Shrivastava S C | 2009 | International Journal of Computer Science and Information Security2009，2，1： | 1 |
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