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| 1 | Regulation of the homeostasis of hepatic endoplasmic reticulum and cytochrome P450 enzymes by autophagy显示文摘The endoplasmic reticulum(ER)is an intracellular organelle consisting of a continuous network of membranes.In the liver,the ER is highly active in protein modification,lipid metabolism,and xenobiotic detoxification.Maintaining these complicated processes requires elaborate control of the ER lumen environment as well as the ER volume.Increasing evidence suggests that autophagy plays a critical role in regulating the homeostasis of hepatic ER contents and levels of cytochrome P450(CYP)enzymes via selective ER-phagy.This review will provide an overview of ER-phagy,summarizing the possible roles of recently identified ER-phagy receptor proteins in regulating the homeostasis of hepatic ER and CYP enzymes as well as outlining the various implications of ER-phagy in ER-related liver diseases. | Xiaowen Ma Clayre Parson Wen-Xing Ding | 2018 | Liver Research2018，2，3： | 3 |
| 2 | Pathogenetic and prog- nostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA Parsons PE | 2007 | Crit Care Med2007，35，8： | 1 |
| 3 | Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury显示文摘 | Parsons PE Matthay MA Ware LB | 2005 | Am J Physiol Lung Cell Mol Physio12005，288，： | 1 |
| 4 | Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury 显示文摘 | Parsons PE Matthay MA Ware LB | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，3： | 1 |
| 5 | Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status显示文摘 | Lue S Zhao H Des Marais DL Parsons EP Wen X Xu X Bangarusamy DK Wang G Rowland O Juenger T Bressan RA Jenks MA | | 0，，： | 1 |
| 6 | Xanthogra nulomatous cholecgstits显示文摘 | Roberts KM Parsons MA | 1987 | J clinpathol1987，40，： | 1 |
| 7 | Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome 显示文摘 | Ware LB Matthay MA Parsons PE | 2007 | Crit Care Med2007，35，8： | 1 |
| 8 | Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury显示文摘 | Eisner MD Parsons P Matthay MA | 2003 | Thorax2003，58，11： | 1 |
| 9 | Lower tidal volume ventilation and plasma eytokine markers of inflammation in patients with acute lung injury显示文摘 | Parsons PE Eisner MD Thompson BT Matthay MA Aneuk- iewiez M Bernard GR | 2005 | Crit Care Med2005，33，1： | 1 |
| 10 | Plasma surfactantprotein levels and clinical outcomes in patients with acute lung injury显示文摘 | Eisner MD Parsons P Matthay MA | 2003 | Thorax2003，58，11： | 1 |
| 11 | A multicentre, random- ized, double- blinded, placebo-controlled phase HI study to investi- gate EXtending the time for Thrombolysis in Emergency Neurologi- cal Deficits ( EXTEND ) 显示文摘 | Ma H Parsons MW Christensen S | 2012 | Int J Stroke2012，7，1： | 1 |
| 12 | Plasma surfac- tant protein levels and clinical outcomes in patients with acute lung injury 显示文摘 | Eisner MD Parsons P Matthay MA | 2003 | Thorax2003，58，11： | 1 |
| 13 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 14 | Plasma surfac- tant protein levels and clinical outcomes in patients with acute lung injury显示文摘 | Eisner MD Parsons P Matthay MA | 2003 | Thorax2003，58，11： | 1 |
| 15 | Health promotion in nursing practice显示文摘 | Pender NJ Murdaugh CL Parsons MA | 2006 | New Jersey:Pearson Prentice Hall2006，，： | 1 |
| 16 | HIV behavioral research online 显示文摘 | Chiasson MA Parsons JT Tesoriero JM | 2006 | J Urban Health2006，83，1： | 1 |
| 17 | Cell adhesion:integrating cytoskeletal dynamics and cellular tension显示文摘 | Parsons JT Horwitz AR Schwartz MA | 2010 | Nat Rev Mol Cell Biol2010，11，9： | 1 |
| 18 | Xanthoganulomatous choleystic: clinicopathological study of 13 cases显示文摘 | Robert KM Parsons MA | 1987 | J Clin pathol1987，40，： | 1 |
| 19 | Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome 显示文摘 | Ware LB Matthay MA Parsons PE | 2007 | Crit Care Med2007，35，8： | 1 |
| 20 | XGC : Clinicopathological study of 13 cases显示文摘 | Roberts KM Parsons MA | 1987 | J Clin Pathol1987，40，4： | 1 |
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