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| 1 | Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer显示文摘Colorectal cancer is the second most leading cause of cancer related deaths in the western countries. One of the forms of colorectal cancer is hereditary non-polyposis colorectal cancer (HNPCC), also known as 'Lynch syndrome'. It is the most common hereditary form of cancer accounting for 5%-10% of all colon cancers. HNPCC is a dominant autosomal genetic disorder caused by germ line mutations in mismatch repair genes. Human mismatch repair genes play a crucial role in genetic stability of DNA, the inactivation of which results in an increased rate of mutation and often a loss of mismatch repair function. Recent studies have shown that certain mismatch repair genes are involved in the regulation of key cellular processes including apoptosis. Thus, differential expression of mismatch repair genes particularly the contributions of MLH1 and MSH2 play important roles in therapeutic resistance to certain cytotoxic drugs such as cisplatin that is used normally as chemoprevention. An understanding of the role of mismatch repair genes in molecular signaling mechanism of apoptosis and its involvement in HNPCC needs attention for further work into this important area of cancer research, and this review article is intended to accomplish that goal of linkage of apoptosis with HNPCC. The current review was not intended to provide a comprehensive enumeration of the entire body of literature in the area of HNPCC or mismatch repair system or apoptosis; it is rather intended to focus primarily on the current state of knowledge of the role of mismatch repair proteins in molecular signaling mechanism of apoptosis as it relates to understanding of HNPCC. | Samar Hassen Nawab Ali Parimal Chowdhury | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 7 |
| 2 | Distribution of ^3H—nicotine in Rat Tissues Under the Influence of Simulated Microgravity显示文摘Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness. | PARIMAL CHOWDHURY MICHAEL E. SOULSBY AND JAMES N. PASLEY (Department of Physiology and Biophysics, University of Arkansas for Medical Scienses, Little Rock, Arkansas 72205, USA) | 1999 | Biomedical and Environmental Sciences1999，12，2： | 6 |
| 3 | The genetics of nicotine dependence:Relationship to Pancreatic cancer显示文摘SmoKing or tobacco products continues to De a major cause of worldwide health problems. Epidemiological studies have shown that tobacco smoking is the greatest risk factor for the development of pancreatic cancer. Smokers who are able to quit smoking can reduce their risk of pancreatic cancer by nearly 50% within two years, however, their risk of developing pancreatic cancer remains higher than that of non-smokers for 10 years. Nicotine is the major psychoactive substance in tobacco, and is responsible for tobacco dependence and addiction. Recent evidence suggests that individuals have genetically based differences in their ability to metabolize nicotine, as well as genetic differences in the psychological reward pathways that may influence individual response to smoking initiation, dependence, addiction and cessation. Numerous associations have been reported between smoking behavior and genetic polymorphisms in genes that are responsible for nicotine metabolism. In addition, polymorphisms in genes that encode neurotransmitters and transporters that function in psychological reward pathways have been implicated in differences in smoking behavior. However, there is a large degree of between-study variability that demonstrates the need for larger, well-controlled case-control studies to identify target genes and deduce mechanisms that account for the genetic basis of inter-individual differences in smoking behavior. Understanding the genetic factors that increase susceptibility to tobacco addiction may result in more effective tobacco cessation programs which will, in turn, reduce the incidence of tobacco related disease, including pancreatic cancer. | Stewart L MacLeod Parimal Chowdhury | 2006 | World Journal of Gastroenterology2006，12，46： | 5 |
| 4 | Mapping of dwarfing gene Rht14 in durum wheat and its effect on seedling vigor, internode length and plant height显示文摘Short coleoptiles associated with GA-insensitive Rht-1 alleles in wheat reduces yield due to poor seedling establishment under dry, or stubble-retained conditions. Hence there is a need for alternative dwarfing genes for wheat improvement programs. GA-sensitive dwarfing gene Rht14 confers semidwarf stature in wheat while retaining longer coleoptiles and early seedling vigor. Two RIL populations were used to identify the map position of Rht14 and to estimate its effect on plant height, coleoptile length, seedling shoot length,spike length and internode length. Rht14 on chromosome 6 A was mapped in the genomic region 383–422 Mbp flanked by GA2oxA9 and wmc753 in a Bijaga Yellow/Castelporziano RIL population. Recombination events between Rht14 and GA2oxA9 in the RIL population indicated that Rht14 might not be allelic to GA2oxA9. The conserved DNA sequence of GA2oxA9 and its flanking region in Castelporziano also suggested that the point of mutation responsible for the Rht14 allele must be a few Mbp away from GA2oxA9. The dwarfing effects of Rht14 on plant height, internode length and seedling vigor were compared with those of Rht-B1 b in an HI 8498/Castelporziano RIL population. Both genes significantly reduced plant height and internode length. Rht-B1 b conferred a significant reduction in coleoptile length and seedling shoot length, whereas Rht14 reduced plant height, but not coleoptile and seedling shoot length. Therefore, Rht14 can be a used as an alternative to Rht-B1 b for development of cultivars suitable for deeper sowing in dry environments and in conditions of conservation agriculture where crop residues are retained. | Parimal Vikhe Suhasini Venkatesan Ajit Chavan Shubhada Tamhankar Ravindra Patil | 2019 | The Crop Journal2019，7，2： | 4 |
| 5 | Nicotine as a mitogenic stimulus for pancreatic acinar cell proliferation显示文摘Cell proliferation is an important process in life for growth of normal and cancer cells. The signal transduction pathways activated during this process are strictly regulated. This editorial focuses on the role of nicotine, a mitogen, in the induction of signaling pathways resulting in proliferation of pancreatic tumor cells and compares these events with those in normal acinar cells isolated from the rat pancreas. The data shows striking similarities between these two cellular systems. In addition, the editorial reviews very recent literature of the contribution of MAPK signaling in cell lines associated with human diseases. A prospective cellular model of nicotine induced activation of MAPK cascade is presented. | Parimal Chowdhury Kodetthoor B Udupa | 2006 | World Journal of Gastroenterology2006，12，46： | 3 |
| 6 | Pediatric femoral shaft fractures treated by flexible intrameduUary nailing显示文摘 | K.C. Kapil Mani R.C. Dirgha Raj Acharya Parimal | 2015 | Chinese Journal of Traumatology2015，18，5： | 2 |
| 7 | Pathophysiology of alcoholic pancreatitis:An overview显示文摘Use of alcohol is a worldwide habit regardless of socio- economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis. The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol induced pancreatitis. Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented. | Parimal Chowdhury Priya Gupta | 2006 | World Journal of Gastroenterology2006，12，46： | 2 |
| 8 | Combined fracture dislocation of the navicular bone along with cuboid, cuneiform and longitudinal split fracture of the lateral malleolus: a rare combination of fractures显示文摘船形的骨头,长方体的破裂,楔形文字,和侧面的踝的纵的裂口骨折的破裂脱臼是破裂的稀罕联合。这是高速度损害破裂并且能被脚的强迫的脚底的屈曲和倒置在影响的时候引起到地面上。这里,我们在被开的减小和固定为侧面的踝与三分之一个管状的盘子为船形的骨头,和二个 interfragmentary 螺丝钉与一个部分线程的螺丝钉和二 K 电线对待的一个 35 岁的男病人报导了如此的一个案例。K 电线被移开 6 在外科以后的星期由部分重量适用列在后面。在 6 以后;月,病人能最小的疼痛地通常走并且脚胀大。 | Kapil Mani Khatri Chhetri Parimal Acharya Dirgha Raj Rokaya Chhetri | 2014 | Chinese Journal of Traumatology2014，17，6： | 2 |
| 9 | Sulfonic acid-functionalized mesoporous silica catalyst with different morphology for biodiesel production显示文摘Sulfonic acid functionalized mesoporous silica based solid acid catalysts with different morphology were designed and fabricated.The synthesized materials were characterized by various physicochemical and spectroscopic techniques like scanning electron microscopeenergy dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,Brunauer–Emmett–Teller surface area,thermogravimetric analysis and n-butylamine acidity.The shape of catalysts particles plays an important role in its activity.The sulfonic acid functionalized mesoporous silica catalysts of spherical shape and the cube shape were assessed for catalytic activity in biodiesel production.The catalytic biodiesel production reaction over the catalysts were studied by esterification of free fatty acid,oleic acid with methanol.The effect of various reaction parameters such as catalyst concentration,acid/alcohol molar ratio,catalyst amount,reaction temperature and reaction time on catalytic activity were investigated to optimize the conditions for maximum conversion.It was sulfonated cubic shape mesoporous silica which exhibited better activity as compared to the spherical shape silica catalysts.Additionally,the catalyst was regenerated and reused up to three cycles without any significant loss in activity.The present catalysts exhibit superior performance in biodiesel production and it can be used for the several biodiesel feedstock’s that are rich in free fatty acids. | Vinayak Hegde Parimal Pandit Pranita Rananaware Varsha PBrahmkhatri | 2022 | Frontiers of Chemical Science and Engineering2022，16，8： | 2 |
| 10 | Regulation of human gonadotropin-releasing hormone receptor gene expression in placental cells显示文摘 | Kwai WA Cheng Parimal SN Peter Leung | 2000 | Endocrinology2000，141，： | 1 |
| 11 | Heteroatom-doped Graphene Materials : Syntheses, Properties and Applications 显示文摘 | WANG X SUN G PARIMAL R | 2014 | Chemical Society Reviews2014，43，： | 1 |
| 12 | National Innovation Systems: Why They Are Important, And How They Might Be Measured And Compared显示文摘 | Parimal Patel Keith Pavitt | 1994 | Economics of Innovation and New Technology1994，，1： | 1 |
| 13 | A biosensor based on co- immobilized L- glutamate oxidase and L- glutamate dehydrogenase for analysis of monosodium glutamate in food 显示文摘 | Anjan K B Parimal C Utpal R | 2006 | Biosensors and Bioelectronies2006，21，： | 1 |
| 14 | Removal of arsenic from contaminated groundwater by membrane-integrated hybrid treatment system显示文摘 | Mou Sen Ajoy Manna Parimal Pal | 2010 | Journal Membrane of Science2010，354，： | 1 |
| 15 | Airspace Complexity Measurement: An Air Traffic Control Simulation Analysis 显示文摘 | Parimal Kopardekar Albert Schwartz Sherri Magyarits | 2009 | International Journal of Industrial Engineering2009，16，1： | 1 |
| 16 | Opitimal auction design and R&D显示文摘 | Parimal Kanlti Bag | 1997 | European Economic Review1997，41，： | 1 |
| 17 | A biosensorbased on co - immobilized L - glutamate oxidase and L - glutamate dehydrogenase for analysis of monosodium glutamate in food 显示文摘 | AN JAN K B PARIMAL C UTPAL R | 2006 | Bioscns Bioelectron2006，21，： | 1 |
| 18 | Process intersification in lactic acid production: a review of membrane based processes显示文摘 | Parimal Pal Jaya Sikder Swapan Roy | 2009 | Chemical Engineering and Processing2009，48，： | 1 |
| 19 | A10N : A brief history of its emergence and evolution 显示文摘 | James W Cauley M Parimal P | 2009 | Journal of the European Ceramic Society2009，29，： | 1 |
| 20 | The Nature and Economic Importance of National innovation system显示文摘 | Patel Parimal and Pavitt keith | 1994 | STI Review1994，，14： | 1 |
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