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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Antiviral activity of ribosome-inactivating proteins in medicine显示文摘 | Parikh B A Tumer N E | 2004 | Mini Rev Med Chem2004，4，5： | 1 |
| 3 | Application of Dempster-Shafer Theory in Condition Monitoring Applications: A Case Study 显示文摘 | Parikh C R Pore M J Jones N B | 2001 | Pattern Recognition Letter2001，，22： | 1 |
| 4 | Ductal carcino- ma in situ with microinvasion : prognostic implications, long - term outcomes, and role of axillary evaluation 显示文摘 | PARIKH R R HAFFTY B G LANNIN D et at | 2012 | Int J Radiat Oncol Biol Phys2012，82，1： | 1 |
| 5 | Sustained src inhibition results in signal transducer and activator of transcription 3 ( stat3 ) activation and cancer cell survival via altered janus-activated kinase-stat3 binding显示文摘 | Sen B Saigal B Parikh N | 2009 | Cancer Res2009，69，： | 1 |
| 6 | Primary chondrosarcoma of lung:case report and review of literature显示文摘 | Shukla K Jetly D Parikh B | 2006 | Indian J Pathol Microbiol2006，49，4： | 1 |
| 7 | Globally distributed content delivery显示文摘 | DILLEY J MAGGS B PARIKH J | 2002 | IEEE Internet Computing2002，6，5： | 1 |
| 8 | Primary intratestieular rhahdomyosareoma in pediatrics显示文摘 | Nasit JG Parikh B Trivedi P | 2013 | Indian J Urol2013，29，1： | 1 |
| 9 | Sustained sre inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-Activated Kinase-STAT3 binding显示文摘 | SEN B SAIGAL B PARIKH N | 2009 | Cancer Res2009，69，5： | 1 |
| 10 | Atmospheric: aerosol profiling with a bistatic imaging lidar system显示文摘 | J E Bernes N C Parikh Sharma T B Kaplan | 2007 | Appl Opt2007，46，15： | 1 |
| 11 | Correlation Between Number of Cross Links per Anhydroglucose Unit and Crease Recovery in DMU-Finished Cotton Fabric显示文摘 | Mehta S B Parikh D V | 1965 | Textile Research Journal1965，35，10： | 1 |
| 12 | Application of dempster-shafer theory in condition monitoring systems:a case study显示文摘 | Parikh C R Pont M J Jones N B | 2003 | Pattem Recognition Letters2003，22，67： | 1 |
| 13 | Distributed optimization and statistical learning via the alternating direction method of multipliers显示文摘 | Boyd S Parikh N Chu E Peleato B Eckstein J | 2011 | Foundations and Trends in Machine Learning2011，3，1： | 1 |
| 14 | Application of dempster-shafer theory in condition monitoring systems: a case study 显示文摘 | Parikh C R Pont M J Jones N B | 2003 | Pattern Recognition Letters2003，22，： | 1 |
| 15 | Radiofre- quency ablation of hepatic metastases显示文摘 | Parikh A A Curley S A Fomage B D | 2002 | Semin Oncol2002，29，2： | 1 |
| 16 | Influence of intermittent pneumatic compression devices on non-invasive blood pressure measurement of the ankle 显示文摘 | Parikh B R Simon A M Kouvaras J N | 2007 | Journal of Clinical Monitoring and Momputing2007，21，6： | 1 |
| 17 | Differentiating fat necro?sis from recurrent malignancy in fat-grafted breasts: an imaging classification system to guide management显示文摘 | Parikh RP Doren EL Mooney B | 2012 | Plast Reconstr Surg2012，130，4： | 1 |
| 18 | Application of dempster-shafer theory in condition monitoring systems: a case study 显示文摘 | PARIKH C R PONT M J JONES N B | 2003 | Pattern Recognition Letters2003，22，2： | 1 |
| 19 | Hal ux valgus interphalangeus deformity:A case series in the pediatric population显示文摘 | Grawe B Parikh S Crawford A | | 0，，01： | 1 |
| 20 | Fluconazole Prophylaxis against Fungal Colonization and Invasive Fungal Infection in Very Low Birth Weight Infants显示文摘 | Tushar B Parikh Ruchi N Nanavati Chandrakant Patankar | 2007 | Indian Pediatrics2007，44，6： | 1 |
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