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| 1 | Role of melatonin on diabetes-related metabolic disorders显示文摘Melatonin is a circulating hormone that is mainly re- leased from the pineal gland. It is best known as a regulator of seasonal and circadian rhythms, its levels being high during the night and low during the day. Interestingly, insulin levels are also adapted to day/night changes through melatonin-dependent synchronization. This regulation may be explained by the inhibiting action of melatonin on insulin release, which is transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 and MT2 and the second messengers 3',5' -cyclic adenosine monophosphate, 3',5'-cyclic guanosine monophosphate and inositol 1,4,5-trisphosphate. Melatonin may influence diabetes and associated metabolic disturbances not only by regulating insulin secretion, but also by providing protection against reactive oxygen species, since pancreatic β-cells are very susceptible to oxidative stress because they possess only low-antioxidative capacity. On the other hand, in several genetic association studies, single nucleotide polymorphysms of the human MT2 receptor have been described as being causally linked to an elevated risk of developing type 2 diabetes. This suggests that these individuals maybe more sensitive to the actions of melatonin, thereby leading to impaired insulin secretion. Therefore, block- ing the melatonin-induced inhibition of insulin secretion may be a novel therapeutic avenue for type 2 diabetes. | Javier Espino José A Pariente Ana B Rodríguez | 2011 | World Journal of Diabetes2011，2，6： | 11 |
| 2 | Biometry of the infrarenal inferior vena cava measured by computed tomography显示文摘 | Ph Bonnichon F Gaudard B Lecam J Shilder D Pariente P O Sarfati Y Chapuis | 1992 | Surgical and Radiologic Anatomy1992，，3： | 1 |
| 3 | Paradoxical immune- mediated inflammation in inflammatory bowel disease patients receiving anti-TNF-a agents 显示文摘 | Fiorino G Danese S Pariente B | 2014 | Autoimmun Rev2014，13，： | 1 |
| 4 | The role of insulin-like growth factor - 1 ( IGF - 1 ) and IGF binding protein - 1 ( IGFBP - 1 ) in the pathogenesis of polycystic ovary syndrome显示文摘 | Homburg R Pariente C Lunenfeld B | 1992 | Human Re- production1992，7，10： | 1 |
| 5 | Mesoporous MCM -41 as drug host sustem 显示文摘 | Rdmila A Mmoz B Perez- Pariente J | 2003 | Sol- gel Sci Techn2003，26，： | 1 |
| 6 | The value ofMRI in the early diagnosis of grow ing skull fracture显示文摘 | Husson B Pariente D Tammam S | 1996 | Pediatr Radiol1996，26，10： | 1 |
| 7 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | PARIENTE B PINETON DE CHAMBRUN G KRZYSIEKR | 2012 | Inflamm Bowel Dis2012，18，7： | 1 |
| 8 | Oxidative stress and immunosenescence:therapeutic effects of melatonin显示文摘 | ESPINO J PARIENTE J A RODRíGUEZ A B | 2012 | Oxidative Medicine and Cellular Longevity2012，2012，67： | 1 |
| 9 | The role of insulin-1ike growth factor-1(IGF-1) and IGF binding protein-1(IGFBP-1) in the pathogenesis of polycystic ovary syndrome显示文摘 | Homburg R Pariente C Lunenfeld B | 1992 | Hum Reprod1992，7，： | 1 |
| 10 | Development of the Crohn's disease digestive damage score, the lemann score 显示文摘 | Pariente B Cosnes J Danese S | 2011 | Inflamm Bowel Dis2011，17，6： | 1 |
| 11 | The value of MRI in the early diagnosis of growing skull fracture显示文摘 | Husson B Pariente D Tammam S | 1996 | Pediatr Radiol1996，26，： | 1 |
| 12 | Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor aspirin/NSAID intake显示文摘 | Charpignon C Lesgourgues B Pariente A | 2013 | Alimentary Pharmacology Ther2013，38，8： | 1 |
| 13 | The role of insulin - like growth factor - 1 ( IGF - 1 ) and IGF binding protein - 1 ( IGFBP - 1 ) in the pathogenesis of polycystic ovary syndrome 显示文摘 | Homburg R Pariente C Lunenfeld B | 1992 | Hum Reprod1992，7，： | 1 |
| 14 | Oxidative stress and immunosenescence:therapeutic effects of melatonin 显示文摘 | Espino J Pariente J A Rodriguez A B | 2012 | Oxid Med Cell Longer2012，，67： | 1 |
| 15 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | Pariente B Pineton de Chambrun G Krzysiek R | 2012 | Inflamm Bowel Dis2012，18，7： | 1 |
| 16 | Can growth hormone increase after clonidine administration predict the dose of human menopausal hormone needed for induction ovulation显示文摘 | MENASHE Y LUNENFELD B PARIENT C | | 0，，： | 1 |
| 17 | The role of insulin-like growth factor-I (IGF-I) and IGF binding protein I (IGFBG-I) in the pathogenesis of polycystic ovary syndrome 显示文摘 | Homburg R Pariente C Lunenfeld B | 1992 | Hum Reprod1992，7，6： | 1 |
| 18 | Development of the Lemann Index to Assess Digestive Tract Damage in Patients with Crohn's Disease显示文摘 | Pariente B Mary J Y Danese S | 2014 | Gastroenterology2014，，： | 1 |
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