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| 1 | Regulation of spermatogenesis by paracrine/autocrine testicular factors显示文摘Spermatogenesis is a complex process regulated by endocrine and testicular paracrine/autocrine factors.Gonadotropins are involved in the regulation of several testicular paracrine factors, mainly of the IL-1 family and testicular hormones. Testicular cytokines and growth factors (such as IL-1, IL-6, TNF, IFN-T, LIF and SCF) were shown to affect both the germ cell proliferation and the Leydig and Sertoli cells functions and secretion. Cytokines and growth factors are produced by immune cells and in the interstitial and seminiferous tubular compartments by various testicular cells, including Sertoli, Leydig, peritubular cells, spermatogonia, differentiated spermatogonia and even spermatozoa. Corresponding cytokine and growth factor receptors were demonstrated on some of the testicular cells. These cytokines also control the secretion of the gonadotropins and testosterone in the testis. Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis. Thus,the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility. (Asian J Androl 2004 Sep; 6: 259-268) | Mahmoud Huleihel Eitan Lunenfeld | 2004 | Asian Journal of Andrology2004，6，3： | 22 |
| 2 | Differentiation of murine male germ cells to spermatozoa n a soft agar culture system显示文摘建立一在里面允许阴囊的细菌房间的发展到精子的 vitro 系统将为男不孕为精子发生和未来治疗的研究是珍贵的。在现在的学习,我们用三维的琼脂文化系统(囊) 处于 vitro 文化条件发展了,它有能力导致阴囊的细菌房间到达精子发生的最后的阶段,包括精子产生。从 7-day-old 老鼠的睾丸的生精的小管酶地被分裂,并且 intratubular 房间在在与胎儿的小牛浆液(FCS ) 补充的 RPMI 媒介的 SACS 的上面的层是有教养的。SACS 的更低的层包含了与 FCS 补充的仅仅 RPMI 媒介。在上面的层的殖民地在文化的 14 和 28 天以后被孤立并且根据他们的尺寸被分类。Immunofluorescence 和即时 PCR 被用来分析在无差别、区分的 spermatogonia 表示的特定的标记(Vasa, Dazl, OCT-4, C 工具包, GFR-α -1, CD9 和 α -6-integrin), meiotic 房间(LDH, Crem-1 和议会) 和 post-meiotic 房间(Protamine-1,精子酵素和 SP-10 ) 。我们的结果表明导致老鼠是可能的阴囊的 pre-meiotic 细菌房间扩大并且在囊导致他们的区别到精子。精子显示出正常形态学并且包含了 acrosomes。因此,我们的结果证明囊能为 pre-meiotic 鼠标细菌房间的成熟在 vitro 系统被用作一篇小说到 post-meiotic 阶段和词法上正常的精子。 | Mahmoud Abu Elhija Eitan Lunenfeld Stefan Schlatt Mahmoud Huleihel | 2012 | Asian Journal of Andrology2012，14，2： | 14 |
| 3 | Aging men-Challenges ahead显示文摘The prolongation of life expectancy and the drastic reduction of fertility rate are the primary cause of an aging world. It is projected that the elderly (above 65) will increase within the next 25 years by 82 %, whereas the new born only by 3 %. Despite the enormous medical progress during the past few decades, the last years of life are still accompanied by increasing ill health and disability. The ability to maintain active and independent living for as long as possible is a crucial factor for aging in health and dignity. Therefore, the promotion of healthy aging and the prevention of disability in men, must assume a central role in medical research and medical practice as well as in the formulation of national health and social policies. Effective programs promoting health and aging will ensure a more efficient use of health and social services and improve the quality of life in older persons by enabling them to remain independent and productive. The most important and drastic gender differences in aging are related to organs and or systems dependant or influenced by reproductive hormones. In distinction to the course of reproductive aging in women, with the rapid decline in sex hormones and expressed by the cessation of menses, aging men experience a slow and continuous decline of hormones. This decline in endocrine function involves: A decrease of testosterone, dehydroepiandrosterone (DHEA),oestrogens, thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and melatonin. This decrease is concomitant with an increase of LH and FSH. In addition sex hormone binding globulin's (SHBG) increase with age resulting in further lowering the concentrations of free biologically active androgens. Interventions such as hormone replacement therapy may prevent, delay or alleviate the debilitating conditions which may result from secondary partial endocrine deficiency. Primary and secondary preventive strategies such as the promotion of a safe environment, healthy lifestyle including proper nutrition, appropriate exercise, avoidance of smoking, avoidance of drug and alcohol abuses, if done effectively, should result in a significant reduction of the health and social costs,reduce pain and suffering, increase the quality of life of the elderly and enable them to remain productive and contribute to the well-being of society. In light of this, public awareness of medical knowledge needs to be increased and basic,clinical, socio-economic and epidemiological research intensified. | Bruno Lunenfeld | 2001 | Asian Journal of Andrology2001，3，3： | 10 |
| 4 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 5 | Androgen therapy in the aging male显示文摘 | LUNENFELD B | 2003 | World J Urol2003，21，5： | 1 |
| 6 | Ovarian stimulation:is there a long-term risk for ovarian,breast and endometrial cancer显示文摘 | Lerner-Geva L Rahinovici J Lunenfeld B | | 0，，： | 1 |
| 7 | 一个老龄化的世界——我们将要面临的挑战显示文摘 | B runo Lunenfeld 田秦杰 | 2002 | 生殖医学杂志2002，11，6： | 1 |
| 8 | Effect of IL-1 Receptor Antagonist Gene Deletion on Mouse Male Fertility显示文摘 | Ganaiem M Abuelhija M Lunenfeld E | 2009 | Endocrinology2009，150，1： | 1 |
| 9 | Relationship between the duration of sexual abstinence and semen quality:analysis of 9,489 se- men samples 显示文摘 | Levitas E Lunenfeld E Weiss N | 2005 | Fertilizer Steril2005，83，： | 1 |
| 10 | Classification of amenorrheic states and their treatment by ovulation induction 显示文摘 | Lunenfeld B Insler V | 1974 | Clin Endocrinol1974，9，3： | 1 |
| 11 | Relationshipbe-tweenageand semen parametersin men with normalspermconcentration:analysisof6022semensamples显示文摘 | LevitasE LunenfeldE WeiszN etal | 2007 | Andrologia2007，39，2： | 1 |
| 12 | Blastocyst stage embryo transfer in patients who failed to conceive in three or more day 2-3embryo trasfer cycles:a prospective,randomized study显示文摘 | Levitas E Lunenfeld E Har Vardi I | 2004 | Fertil Steil2004，81，3： | 1 |
| 13 | Blastocyst - stage embry- o transfer in patients who failed to conceive in three or more day 2 - 3 embryo transfer cycles: a prospective, randomized study 显示文摘 | Levitas E Lunenfeld E Hat - Vardi I | 2004 | Fertil Stefi12004，81，： | 1 |
| 14 | In Vitro Fertilization and Risk of Breast and Gynecologic Cancers: A Retrospective Cohort Study within the Israeli Maccabi Healthcare Services显示文摘 | Louise A. Brinton Britton Trabert Varda Shalev Eitan Lunenfeld Tal Sella Gabriel Chodick | 2012 | Fertility and Sterility2012，，： | 1 |
| 15 | The relationship between endogenous oestradiol and vitamin D3 metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer显示文摘 | Potashnik G Lunenfeld E Levitas E | 1992 | Hum Reprod1992，7，10： | 1 |
| 16 | Historical perspectives in gonadotrophin therapy 显示文摘 | Lunenfeld B | 2004 | Hum Reprod Update2004，10，6： | 1 |
| 17 | The role of insulin-like growth factor - 1 ( IGF - 1 ) and IGF binding protein - 1 ( IGFBP - 1 ) in the pathogenesis of polycystic ovary syndrome显示文摘 | Homburg R Pariente C Lunenfeld B | 1992 | Human Re- production1992，7，10： | 1 |
| 18 | ISA, ISSAM and EAU recommendations for the investigation, treatment and monitoring of late-onset hypogonadism in males: scientific background and rationale 显示文摘 | Lunenfeld B Saad F Hoesl CE | 2005 | Aging Male2005，8，2： | 1 |
| 19 | Investigation, treatment and monitoring of late-onset hypogonadism in males 显示文摘 | Morales A Lunenfeld B | 2002 | Aging Male2002，5，2： | 1 |
| 20 | Evidence of gonadal and gonadotrophin antibodies in women with a suboptimal ovarian response to exogenous gonadotrophin显示文摘 | Meyer WR Lunenfeld B Eshel A | 1990 | Fertil Steril1990，75，5： | 1 |
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