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| 1 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 2 | Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study显示文摘 | Loukianos S Rallidis Christos K Drakoulis Aikaterini S Parasi | 2004 | Atherosclerosis2004，，1： | 2 |
| 3 | Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival 显示文摘 | Theocharis S Giaginis C Parasi A | 2007 | Dig Dis Sci2007，52，9： | 1 |
| 4 | Prognostic impact of DNA ploidy pattern, S--phase fraction (SPF), and proliferating cell nuclear antigen (PCNA) in patients with primary gastric lymphoma显示文摘 | Belessi GJ Parasi AS Manioudaki HS | 2003 | J Surg Oncol2003，82，4： | 1 |
| 5 | Pravastatin in patients with nonalcoholic steatohepatitis:results of a pilot study显示文摘 | Rallidis LS Drakoulis CK Parasi AS | 2004 | Atherosclerosis2004，174，1： | 1 |
| 6 | The expression of ma-trix metalloproteinases-2 and-9 and their tissue inhibitor 2 in pan-creatic ductal and ampullary carcinoma and their relation to angio-genesis and clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | | 0，，3： | 1 |
| 7 | The expression of matrix metalloproteinases-2 and-9 and their tissue inhibitor 2in pancreatic ductal and ampullary carcinoma and their relation to angiogenesisand clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
| 8 | The expressionof matrixmetalloproteinases-2and-9and their tissue inhibitor2in pancreatic ductal and ampullary carcinoma and theirrelation to angiogenesis and clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
| 9 | Expression of poroxisome proliferator-activated receptor-gamma in colon cancer:correlation with histopathological parameters,cell cycle-related molecules,and patients'survival显示文摘 | Theocharis S Giaginis C Parasi A | 2007 | Dig Dis Sci2007，52，9： | 1 |
| 10 | Pravastatin in patients with nonalcoholic steatohepatitis:results of a pilot study显示文摘 | Rallidis LS Drakoulis CK Parasi AS | 2004 | Atherosclerosis2004，174，1： | 1 |
| 11 | Pseudosarcomatous myofihroblastic lesion of the urinary bladder: A rare entity posing a diagnostic chal- lenge and therapeutic dilemma 显示文摘 | Lekas A Parasi A Papathomas TG | 2008 | Diagn Pathol2008，3，： | 1 |
| 12 | Prognostic impact of DNA ploidy pattern,S-phase fraction (SPF) and proliferating cell nuclear antigen (PCNA) in patients with primary gastric lymphoma显示文摘 | Belessi CJ Parasi AS Manioudaki HS | 2003 | J Surg Oncol2003，82，4： | 1 |
| 13 | S-phase fraction(SPF), and proliferating cell nuclear antigen (PCNA) in patients with primary gastric lymphoma显示文摘 | Belessi CJ Parasi AS Manioudaki HS | 2003 | J Surg Oncol2003，82，4： | 1 |
| 14 | Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients'survival显示文摘 | Theocharis S Giaginis C Parasi A | 2007 | Dig Dis Sci2007，52，9： | 1 |
| 15 | Pravastatin in patients with non-alcoholic steatohepatitis , results of a pilot study显示文摘 | Rallidis LS Drakoulis CK Parasi AS | 2004 | Atherosclerosis2004，174，1： | 1 |
| 16 | proGnostic aimpact of DNA ploidy pattern, S - phase fractions (Spf) and pro- liferation cells nuclear antiGen (pcna) in apatients with primary Gastrict lymphoma 显示文摘 | Belessi c J parasi aS ManioudaKi hs Laoutaris Np Le- gakis Nc peros GT androulakis Ga | 2003 | Jsmrgomf2003，82，4： | 1 |
| 17 | The expression of matrix metalloproteinases-2 and-9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and atholocal parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | | 0，，3： | 1 |
| 18 | The expression of ma-trix metalloproteinases-2 and-9 and their tissue inhibitor 2 in pancre-atic ductal and ampullary carcinoma and their relation to angiogenesisand clinicopathological parameters显示文摘 | Giannopeulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
| 19 | Pressor drugs in the treatment of cardiac arrest显示文摘 | Parasis NA Wenzel V Southall J | 2002 | Cardiol Clin2002，20，1： | 1 |
| 20 | The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic duetal and ampuUary carcinoma and their relation to angiogenesis and clinicopathological parameters 显示文摘 | Giannopoulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
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