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| 1 | Clinicopathological differences and correlations between right and left colon cancer显示文摘BACKGROUND The differences in histopathology and molecular biology between right colon cancer(RCC)and left colon cancer(LCC)were first reported in the literature by Bufill in 1990.Since then,a large number of studies have confirmed their differences in epidemiology,clinical presentation,comorbidities and biological behaviours,which may be related to the difference in prognosis and overall survival(OS)between the two groups.AIM To investigate statistically significant differences between Greek patients with LCC and RCC.METHODS The present observational study included 144 patients diagnosed with colon cancer of any stage who received chemotherapy in a Greek tertiary oncology hospital during a 2.5-year period.Clinical information,comorbidities,histopathologic characteristics and molecular biomarkers were collected from the patients’medical records retrospectively,while administered chemotherapy regimens,targeted agents,progression-free survival(PFS)periods with first-and second-line chemotherapy and OS were recorded retroactively and prospectively.Data analysis was performed with the SPSS statistical package.RESULTS Eighty-six males and 58 females participated in the study.One hundred(69.4%)patients had a primary lesion in the left colon,and 44(30.6%)patients had a primary lesion in the right colon.Patients with RCC were more likely to display anaemia than patients with LCC[odds ratio(OR)=3.09],while LCC patients were more likely to develop rectal bleeding(OR=3.37)and a feeling of incomplete evacuation(OR=2.78)than RCC patients.Considering comorbidities,RCC patients were more likely to suffer from diabetes(OR=3.31)and coronary artery disease(P=0.056)than LCC patients.The mucinous differentiation rate was higher in the right-sided group than in the left-sided group(OR=4.49),as was the number of infiltrated lymph nodes(P=0.039),while the percentage of high-grade differentiation was higher in the group of patients with left-sided colon cancer than in RCC patients(OR=2.78).RAS wild-type patients who received anti-epidermal growth factor receptor(EGFR):Treatment experienced greater benefit(PFS:16.5 mo)than those who received anti-vascular endothelial growth factor treatment(PFS:13.7 mo)(P=0.05),while among RAS wild-type patients who received anti-EGFR treatment,LCC patients experienced greater benefit(PFS:15.8 mo)than the RCC subgroup(PFS:5.5 mo)in the first-line chemotherapy setting(P=0.034).BRAF-mutant patients had shorter PFS(9.3 mo)than BRAF wild-type patients(14.5 mo)(P=0.033).RCC patients showed a shorter tumour recurrence period(7.7 mo)than those with LCC(14.5 mo)(P<0.001),as well as shorter(OS)(58.4 mo for RCC patients;82.4 mo for LCC patients)(P=0.018).CONCLUSION RCC patients present more comorbidities,worse histological and molecular characteristics and a consequently higher probability of tumour recurrence,poor response to targeted therapy and shorter OS than LCC patients. | Ioannis Kalantzis Afroditi Nonni Kitty Pavlakis Eumorphia-Maria Delicha Konstantinos Miltiadou Christos Kosmas Nikolaos Ziras Konstantinos Gkoumas Harikleia Gakiopoulou | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 2 | Occipital-parietal encephalopathy:a new name for an old syndrome显示文摘 | Pavlakis SG Frank Y Kalina P | 1997 | Pediatr Neurol1997，16，2： | 1 |
| 3 | The clinical signi ficance of axillary lymph node micrometastases in breast cancer显示文摘 | Sakorafas GH Geraghty J Pavlakis G | 2004 | Eur J Surg Oncol2004，30，8： | 1 |
| 4 | Management of cardiogenic shock due to acute coronary syndromes显示文摘 | Bouki KP Pavlakis G Papasteriadis E | 2005 | Angiology2005，56，2： | 1 |
| 5 | A systematic review of platinum and taxane resistance from bench to clinic:an inverse relationship显示文摘 | tordal B Pavlakis N Davey R | | 0，，08： | 1 |
| 6 | Safety and effi-cacy of first-line bevacizumab-based therapy in advanced non-squamous non-small cell lung cancer(SAiL,MO19390):a phase4 study显示文摘 | Crino L Dansin E Garrido P Griesinger F Laskin J Pavlakis N Stroiakovski D Thatcher N Tsai CM Wu YL Zhou C | 2010 | Lancet Oncol2010，11，8： | 1 |
| 7 | Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection 显示文摘 | Petrovas C Chaon B Amhrozak DR Price DA Melen- horst JJ Hill BJ Geldmacher C Casazza JP Chatto- padhyay PK Roederer M Douek DC Mueller YM Jacob- son JM Kulkarni V Felber BK Pavlakis GN Katsikis PD Koup RA | 2009 | J Immunol2009，183，2： | 1 |
| 8 | Study of thalidomide in the treatment of recurrent glioblastoma muhiforme显示文摘 | Marx GM Pavlakis N Mc Cowatt S | 2002 | J Neuro Oncol2002，54，1： | 1 |
| 9 | Current treatment concepts for neuromas-in-continuity 显示文摘 | Mavrogenis AF Pavlakis K Stamatoukou A | 2008 | Injury2008，39，3： | 1 |
| 10 | Mitochondfial myopathy, encepha- lopathy, lactic acidosis, and strokelike episodes (ME- LAS): current concepts 显示文摘 | Hirano M Pavlakis SG | 1994 | J Child Neural1994，9，1： | 1 |
| 11 | Peripheral neuropathies in Sjogren' s syndrome:A criti- cal update on clinical features and pathogenetic mechanisms 显示文摘 | Pavlakis PP | 2012 | Journal of Autoimmunity2012，39，12： | 1 |
| 12 | Mitochondrial myopa- thy, encephalopathy, lactic acidosis, and strokelike episodes : a dis- tinctive clinical syndrome显示文摘 | Pavlakis SG Phillips PC l)iMaum S | 1984 | Ann Neurol1984，16，： | 1 |
| 13 | Mitochondria myopathy, encephalopathy, lactic acidosis, and strokelike episodes:a distinctive clinical syndrome显示文摘 | Pavlakis SG Phillips PC DiMauro S | 1984 | Ann Neurol1984，16，： | 1 |
| 14 | The medical evaluation of living kidney donors : a survey of US transplant centers 显示文摘 | Mandelbrot DA Pavlakis M Danovitch GM | 2007 | Am J Transplant2007，，7： | 1 |
| 15 | Management of cardiogenic shock due toaccute coronary syndiomes显示文摘 | Bouki kp Pavlakis G Papasteriadis E | 2005 | Angiology2005，56，： | 1 |
| 16 | Safety climate in 5 intensive care units: a nationwide hospital survey using the Greek-Cypriot version of the safety attitudes questionnaire显示文摘 | Raftopoulos V Pavlakis A | 2013 | J Crit Care2013，28，1： | 1 |
| 17 | A pre-tailored panel of antibodies in the study of cervical mesonephric remnants显示文摘 | Pavlakis K Messini I Yiannou P | 2010 | Gynecol Oncol2010，116，3： | 1 |
| 18 | High blood neu- trophil-to-lymphocyte ratio is an indicator of poor prog- nosis in malignant mesothelioma patients undergoing systemic therapy显示文摘 | Kao S C Pavlakis N Harvie R | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 19 | Hypertensive encephalopathy, reversible occipitoparietal encephalopa- thy, or reversible posterior leukoencephalopathy: three names for an old syndrome 显示文摘 | PAVLAKIS S G FRANK Y CHUSID R | 1999 | J Child Neurol1999，，5： | 1 |
| 20 | Prognostic signific Ance of HER3 And HER4 protein expression in colorect Al Adenoc Arcinom As显示文摘 | Kountourakis P Pavlakis K Psyrri A | 2006 | BMC CAncer2006，28，6： | 1 |
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