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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | New serological markers in pediatric patients with inflammatory bowel disease显示文摘The spectrum of serological markers associated with inflammatory bowel disease(IBD)is rapidly growing.Due to frequently delayed or missed diagnoses,the application of non-invasive diagnostic tests for IBD,as well as differentiation between ulcerative colitis(UC)and Crohn’s disease(CD),would be useful in the pediatric population.In addition,the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody(pANCA)improved the sensitivity of serological markers in pediatric patients with CD and UC.Some studies suggested that age-associated differences in the patterns of antibodies may be present,particularly in the youngest children.In CD,most patients develop stricturing or perforating complications,and a significant numberof patients undergo surgery during the disease course.Based on recent knowledge,serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery.Pediatric UC is characterized by extensive colitis and a high rate of colectomy.In patients with UC,high levels of antiCBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis.Thus,serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression.In conclusion,identification of patients at an increased risk of rapid disease progression is of great interest,as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD,and reduce complications and hospitalizations. | Márta Kovács Katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 3 | Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever显示文摘 | Walsh TJ Papps P Winston DJ | | 0，，： | 2 |
| 4 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 5 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 6 | Rcitalopram counteracts the antidepressant like effect of escitalopram in a rat chronic mild stress model of de2pression 显示文摘 | Sanchez C Gruca P Papp M | 2003 | Behav Pharmacol2003，14，： | 1 |
| 7 | Pharmacological mecha-nisms contributing to the clinical efficacy of Levosimendan 显示文摘 | Papp Z Csapo K Pollesello P | 2005 | Cardiovasc Drug Rev2005，23，1： | 1 |
| 8 | Chronic mild stress-induced anhedonia:a realistic animal model of depression显示文摘 | Willner P Muscat R Papp M | | 0，，： | 1 |
| 9 | mieroRNA modulation of circadian-clock period and entrainment显示文摘 | Cheng H Y Papp J W Varlamova O Dziema H Russell B Cur- fman J P | 2007 | Neuron2007，54，： | 1 |
| 10 | High frequency of methylenetetrahydr-ofolate reductase 677TT genotype in Hungarian HELLP syndromepatients determined by quantitative real-time PCR显示文摘 | Nagy B’Hupuczi P Papp Z | 2007 | J HumHypertens2007，21，2： | 1 |
| 11 | Selective blockade of drug-induced place preference conditioning by ACPC,a functional NDMA-receptor antagonist显示文摘 | Papp M Gruca P Willner P | 2002 | Neuropsychopharmacology2002，27，5： | 1 |
| 12 | Effect of an intermittent lighting schedule on doe and suckling rabbit's performance显示文摘 | Virág Gy Papp Z Rafai P | | 0，，01： | 1 |
| 13 | The cardioprotective effects of levo-simendan:preclinical and clinical evidence显示文摘 | Papp Z | 2007 | J Cardio-vasc Pharmacol2007，50，3： | 1 |
| 14 | Nerve-sparing radical hysterectomy for stage Ⅰ A2-ⅡB cervical cancer: 5 years survival of 501 consecutive cases显示文摘 | Papp Z Csapo Z Hupuczi P | 2006 | EurJ GynaecoI Onco12006，27，6： | 1 |
| 15 | Pharmacological mechanisms contributing to the clinical efficacy of levosimendan显示文摘 | Papp Z Csap6 K Pollesello P | 2005 | Cardio- vasc Drug Rev2005，23，1： | 1 |
| 16 | A comparative assessment of measures of similarity of fuzzy values 显示文摘 | PAPPS C P KARACAPILIDIS N I | 1993 | Fuzzy Sets and Systems1993，56，2： | 1 |
| 17 | Cells with regulato ry funetion of the innate and adaptive immune system in pri- mary Sjogren's syndrome 显示文摘 | Szodoray P Papp G Horvath IF | 2009 | Clin Exper Immunol2009，157，： | 1 |
| 18 | Anti-IL-17 receptor antibody AMG 827 lesds to rapid clinical response in subjects with moderate to severe psoriasis:resuilts from a phase I,randomized,placebo-controlled trial显示文摘 | Papp KA Reid C Foley P | 2012 | J Invest Dermatol2012，132，10： | 1 |
| 19 | Urgent super-selective segmental renal artery embolization in the treatment of life threatening renal hemorrhage显示文摘 | Papps P Leonardou P Papadoukakis S | 2006 | Urol Int2006，77，1： | 1 |
| 20 | Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline显示文摘 | Muscat T R Papp M Willner P | 1992 | Psyckopharmacology(Berl)1992，109，4： | 1 |
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