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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Overexpression of an ABA biosynthesis gene using a stress-inducible promoter enhances drought resistance in petunia显示文摘The response of plants to drought stress includes reduced transpiration as stomates close in response to increased abscisic acid(ABA)concentrations.Constitutive overexpression of 9-cis-epoxycarotenoid dioxygenase(NCED),a key enzyme in ABA biosynthesis,increases drought resistance,but causes negative pleiotropic effects on plant growth and development.We overexpressed the tomato NCED(LeNCED1)in petunia plants under the control of a stress-inducible promoter,rd29A.Under water stress,the transgenic plants had increased transcripts of NCED mRNA,elevated leaf ABA concentrations,increased concentrations of proline,and a significant increase in drought resistance.The transgenic plants also displayed the expected decreases in stomatal conductance,transpiration,and photosynthesis.After 14 days without water,the control plants were dead,but the transgenic plants,though wilted,recovered fully when re-watered.Well-watered transgenic plants grew like non-transformed control plants and there was no effect of the transgene on seed dormancy. | Alejandro C Estrada-Melo Chao Ma Michael S Reid Cai-Zhong Jiang | 2015 | Horticulture Research2015，2，1： | 12 |
| 4 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 5 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 6 | Novol gaseous inhibitor of ethylene binding prevents ethylene effects in potted flowering plant显示文摘 | Serek M Sisler E C Reid M S | 1994 | J Amer Soc Hort Sci1994，119，： | 1 |
| 7 | Bioavailability of persistent organic pollutants in soils and sedimentsa perspective on mechanisms, consequences and assessment 显示文摘 | REID B J JONES K C SEMPLE K T | 2000 | Environmental Pollution2000，108，1： | 1 |
| 8 | Investigation into the biological stability of collagen/chondroitin-6-sulphate gels and their contraction by fibroblasts and keratinocytes: the effect of crosslinking agents and diamines显示文摘 | Osborne C S Reid W H Grant M H | 1999 | Biomaterials1999，20，3： | 1 |
| 9 | Characteri-zation of 40G-bit/s Pulses Generated Using a LiNbO3 Modulator at 1550 nm Using Frequency Resolved Optical Gating显示文摘 | Benn C Thomen Douglas A Reid | 2004 | IEEE Transaction on Instrumentation and Measurement2004，53，1： | 1 |
| 10 | Frequency of under-and overfeeding in mechanically ventilated ICU patients:causes and possible consequences显示文摘 | REID C | 2006 | J Hum Nutr Diet2006，19，1： | 1 |
| 11 | Acute and chronic effects of neur- otrophic factors BDNF and GDNF on responses mediated by thermo- sensitive TRP channels in cultured rat dorsal root ganglion neurons 显示文摘 | Ciobanu C Reid G Babes A | 2009 | Brain Res2009，1284，11： | 1 |
| 12 | New therapcutic opportunities in epilepsy: A genetic perspective 显示文摘 | Reid C A Jackson G D Berkovic S F | 2010 | Pharmacol Ther2010，1289，2： | 1 |
| 13 | Effects of nitrogen and phosphorus on blue grama growth and mycorrhizal infection 显示文摘 | Hays R Reid C C P John T V St Coleman D C | 1982 | Oecologia1982，54，： | 1 |
| 14 | Environmental influences on bamboo Bashania fangiana growth and implications for giant panda conservation 显示文摘 | Reid D G Taylor A H Hu J C | 1991 | Journal of Applied Ecology1991，28，： | 1 |
| 15 | Mechanisms of human inherited epilepsies 显示文摘 | Reid C A Berkovic S F Petrou S | 2009 | Prog Neurobiol2009，87，1： | 1 |
| 16 | Bioavailability of persistent organic pollutions in soils and sediments-a perspective on mechanisms, consequences and assessment显示文摘 | REID B J JONERS K C SEMPLE K T | 2000 | Environmental Pollution2000，108，： | 1 |
| 17 | The use of silver thiosulfate anionic complex as a foliar spray to prevent flower abscission of Zygocactus显示文摘 | ameron A C Reid M S | 1981 | Hort Science1981，16，： | 1 |
| 18 | Prediction of intake by cattle from degradation characteristics of roughages显示文摘 | φrskov E R Reid C W Kay M | 1988 | Anim Prod1988，46，： | 1 |
| 19 | Red/far-red light mediated stem elongation and anthocyanin accumulation in Stellaria longipes: Differential response of alpine and prairie ecotypes显示文摘 | Suneetha Alokam Chinnappa C C David M Reid | 2002 | Canadian Journal of Botany2002，80，： | 1 |
| 20 | Effect of 1 - MCP on the vase life and ethylene response of cut flow - ers显示文摘 | Serek M Sisler E C Reid M S | 1995 | Plant Grow Regul1995，16，： | 1 |
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