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| 1 | Osteoporosis in primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with multiple debilitating complications. Osteoporosis is a common complication of PBC resulting in frequent fractures and leading to significant morbidity in this population, yet evidence for effective therapy is lacking. We sought to summarize our current understanding of the pathophysiology of osteoporosis in PBC, as well as current and emerging therapies in order to guide future research directions. A complete search with a comprehensive literature review was performed with studies from Pub Med, EMBASE, Web of Science, Cochrane database, and the Countway Library. Osteoporosis in PBC is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Despite this fundamental difference, current treatment recommendations are based primarily on experience with postmenopausal osteoporosis. Trials specific to PBC-related osteoporosis are small and have not consistently demonstrated a benefit in this population. As it stands, prevention of osteoporosis in PBC relies on the mitigation of risk factors such as smoking and alcohol use, as well as encouraging a healthy diet and weight-bearing exercise. The primary medical intervention for the treatment of osteoporosis in PBC remains bisphosphonates though a benefit in terms of fracture reduction has never been shown. This review outlines what is known regarding the pathogenesis of bone disease in PBC and summarizes current and emerging therapies. | Christopher J Danford Hirsh D Trivedi Konstantinos Papamichael Elliot B Tapper Alan Bonder | 2018 | World Journal of Gastroenterology2018，24，31： | 13 |
| 2 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 3 | Docetaxel and irinotecan as second-line therapy for advanced oesophagogastric cancer显示文摘 | Hawkes E Okines AF Papamichael D | | 0，，08： | 1 |
| 4 | Treatment of the elderly colorectal cancer patient:SIOG expert recommendations显示文摘 | PAPAMICHAEL D AUDISIO R HORIOT J C | 2009 | Annals of Oncology2009，20，1： | 1 |
| 5 | Treatment of the elderly colorectal cancer patient:SIOG expert recommendatio- ns显示文摘 | Papamichael D Audisio R Horiot J C eta| | 2012 | Ann Onco12012，20，1： | 1 |
| 6 | A Monte Carlo study of sub-keV electron transport in water:The influence of the condensed phase显示文摘 | Emfietzoglou D Papamichael G Androulidakis I | 2005 | Nuclear Instruments and Method B2005，228，： | 1 |
| 7 | Treatment of the elderly col- orectal cancer patient: SIOG expert recommendations 显示文摘 | Papamichael D Audisio R Horiot JC | 2009 | Ann Oncol2009，20，1： | 1 |
| 8 | Treatment of colorectal cancer in old-er patients显示文摘 | Audisio RA Papamichael D | | 0，，12： | 1 |
| 9 | Immunocytoma: a retrospective analysis from St Bartholomew's Hospital-1972 to 1996显示文摘 | Papamichael D Norton AJ Foran JM | 1999 | J Clin Oncol1999，17，9： | 1 |
| 10 | Revelsible de novo left ventricular trabeculations in pregnant women:implications for the diagnosis of left ventricular nincompaction in low-risk populations显示文摘 | Gati S Papadakis M Papamichael N D | 2014 | Circulation2014，130，6： | 1 |
| 11 | Docetaxel and irinotecan as second-line therapy for advanced oesophagogastric cancer显示文摘 | Hawkes E Okines AF Papamichael D | 2011 | Eur J Cancer2011，47，8： | 1 |
| 12 | Epirubicin, cisplatin and oral UFT with leucovorin(ECU) :A phase I - II study in patients with advanced upper gastrointestinal tract cancer显示文摘 | Seymour MT Dent JT Papamichael D | 1999 | Ann Oncolo1999，10，11： | 1 |
| 13 | Epirubicin,cisplatin and oral UFT with leucovorin(‘ECU'):A phase Ⅰ-Ⅱ study in patients with advanced upper gastrointestinal tract cancer显示文摘 | Seymour MT Dent JT Papamichael D | 1999 | Ann Oncol1999，10，11： | 1 |
| 14 | A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits显示文摘 | Roussa V D Stathopoulou E M Papamichael N D | 2011 | Platelets2011，22，5： | 1 |
| 15 | Docetaxel and irinote- can as second -line therapy for advanced esophagogastric cancer显示文摘 | Hawkes E Okines AF Papamichael D | 2011 | Eur J Cancer2011，47，8： | 1 |
| 16 | Patterns of clini-cal presentation, treatment, and outcome in patients with Walden-strom -s macroglobulinemia : a two - institution study 显示文摘 | Bjorkholm M Johansson E Papamichael D | 2003 | SeminOncol2003，30，2： | 1 |
| 17 | A Monte Carlo study of sub-keV electron transport in water: the influence of the condensed phase显示文摘 | Emfietzoglou D Papamichael G Androulidakis I | 2005 | Nuclear Instruments and Methods in Physics Research Section B2005，228，14： | 1 |
| 18 | Comparison of ESC and NICE guidelines for patients with suspected coronary artery disease : evaluation of the pre - test probability risk scores in clinical practice 显示文摘 | DEMIR O M DOBSON P PAPAMICHAEL N D | 2015 | Clin Med (Lond)2015，15，3： | 1 |
| 19 | Treatment of the elderly colorectalcancer patient: SlOG expert recommen- dations 显示文摘 | Papamichael D Audisio R Horiot JC | 2009 | Ann Oncol2009，20，1： | 1 |
| 20 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 1 |
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