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| 1 | Prognostic angiogenic markers(endoglin, VEGF, CD31) and tumor cell proliferation(Ki67) for gastrointestinal stromal tumors显示文摘AIM: To evaluate the correlation between the immunoexpression of angiogenic markers [CD31, CD105 and vascular endothelial growth factor(VEGF)], proliferative index(Ki67), and prognosis of patients with gastrointestinal stromal tumors(GIST).METHODS: This is a retrospective study of 54 GIST cases. Medical records were searched to obtain the GIST patients' demographic and clinical data, and paraffin-embedded blocks of tumor samples were retrieved from the hospital archives to conduct a new immunohistochemical evaluation. The tumor samples of GIST patients were subject to immunohistochemical evaluation for endoglin(CD105), CD31, VEGF, and Ki67 expression. The CD105 and CD31 intratumoral microvascular density(IMVD) was measured using automated analysis. We determined the correlation between the immunoexpression of CD105, CD31, VEGF,Ki67 and prognosis. In addition, we conducted a cutoff analysis using the receiver-operating characteristic curve. VEGF positivity was classified as either null/weak or strong. Ki67 was evaluated using a cutoff of 5%positive cells. The prognosis was classified as good(patient alive without recurrence) or poor(patient with recurrence/death).RESULTS: The distribution of tumor sites among the54 analyzed samples was as follows: 27(50%) in the stomach, 20(37.1%) in the small intestine, 6(11.1%)in the colon, and 1(1.8%) in the esophagus. The size of the tumors ranged from 2 to 33 cm(median: 8cm); in 12 cases(22.2%), the tumor was below 5 cm at the largest diameter, but in 42 cases(77.7%), the tumor was larger than 5 cm. The means of CD105 and CD31 were significantly higher in the group with poor prognosis(P < 0.001). The cut-off values of CD105(>1.2%) and CD31(> 2.5%) in the receiver-operating characteristic curve were related to a poorer prognosis.Cases with a better prognosis showed significantly null/weak staining for VEGF(P < 0.001). Ki-67 expression of≥ 5% was strongly correlated with a worse prognosis(P< 0.001). In the multivariate analysis, CD105 was the variable that most strongly correlated with prognosis.CONCLUSION: The IMVD cutoff values for the angiogenic markers CD105 and CD31, may be prognostic factors for GIST, in addition to VEGF and Ki67. | Rodrigo Panno Basilio-de-Oliveira Vera Lucia Nunes Pannain | 2015 | World Journal of Gastroenterology2015，21，22： | 15 |
| 2 | Effects of psoralens as anti-tumoral agents in breast cancer cells显示文摘This review examines the biological properties of coumarins, widely distributed at the highest levels in the fruit, followed by the roots, stems and leaves, by considering their beneficial effects in the prevention of some diseases and as anti-cancer agents. These compounds are well known photosensitizing drugs which have been used as pharmaceuticals for a broad number of therapeutic applications requiring cell division inhibitors. Despite this, even in the absence of ultraviolet rays they are active. The current paper mainly focuses on the effects of psoralens on human breast cancer as they are able to influence many aspects of cell behavior, such as cell growth, survival and apoptosis. In addition, analytical and pharmacological data have demonstrated that psoralens antagonize some metabolizing enzymes, affect estrogen receptor stability and counteract cell invasiveness as well as cancer drug resistance. The scientific findings summarized highlight the pleiotropic functions of phytochemical drugs, given that recently their target signals and how these are modified in thecells have been identified. The encouraging results in this field suggest that multiple modulating strategies based on coumarin drugs in combination with canonical chemotherapeutic agents or radiotherapy could be a useful approach to address the treatment of many types of cancer. | Maria Luisa Panno Francesca Giordano | 2014 | World Journal of Clinical Oncology2014，5，3： | 3 |
| 3 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 4 | SIRT3 gene expression: a link between inherited mitocbondrial DNA variants and oxidative stress显示文摘 | D'Aquila P Rose G Panno ML | 2012 | Gene2012，497，2： | 1 |
| 5 | Hydrochemistry of the Mahomet Bedrock Valley Aquifer, East-Central IIIinois: Indicators of Recharge and Groundwater Flow显示文摘 | Panno S V Hackley K C Carteright K | 1994 | Ground Water1994，32，4： | 1 |
| 6 | Use of se- lected autochthonous soil bacteria to enhance degradation of hydrocarbons in soil 显示文摘 | Vecchioli G I Del Panno M T Painceira M T | 1990 | Environmental Pollution1990，67，3： | 1 |
| 7 | A fuzzy algorithm for combined control of traffic parameters: assessment and key issues显示文摘 | Ficili G Panno D | 1999 | Computer Communications1999，22，3： | 1 |
| 8 | Isotopic Evidence of Nitrate Sources and Denitrification in the Mississippi River, Illinois 显示文摘 | Panno S V Hackley K C Kelly W R | 2006 | J Environ Qual2006，35，： | 1 |
| 9 | Sources and fate of nitrate in the Illinois river basin, illinois 显示文摘 | Panno S V Kelly W R Hackley K C | 2008 | Journal of Hydrology2008，359，12： | 1 |
| 10 | Isotopic Evidence of Nitrate Sources and Denitrification in the Mississippi River, Illinois 显示文摘 | Panno S V Hackley K C Kelly W R | 2006 | Journal of Environmental Quality2006，35，2： | 1 |
| 11 | Determination of the sources of nitrate contamination in karst springs using isotopic and chemical indicators 显示文摘 | Panno S V Hackley K C Hwang H H | 2001 | Chemical Geology2001，179，14： | 1 |
| 12 | Potential applications using LNG cold energy in Sicily显示文摘 | MESSINEO A PANNO D | 2008 | Int J Energy Res2008，32，11： | 1 |
| 13 | Evidence that bergapten, independently of its photoactivation, enhances p53 gene expression and induces apoptosis in human breast cancer cells 显示文摘 | Panno ML Giordano F Palma MG | 2009 | Current Cancer Drug Targets2009，9，： | 1 |
| 14 | Use of selected autochthonous soil bacteria to enhance degradation of hydrocarbons in soil显示文摘 | Vecchioli G I Del Panno M T Painceira M T | 1990 | Environ Pollut1990，67，3： | 1 |
| 15 | Haemorheological components in the pre-geriatric and geriatric age range in a randomly selected western Sicily population sample (Cas-teldaccia Study)显示文摘 | Avellone G Garbo D Panno AV | | 0，，： | 1 |
| 16 | Determination of bromine, chlorine and iodine in environmental aqueous samples by epithermal neutron activation analysis and Compton suppression显示文摘 | S. Landsberger D. J. O’Kelly J. Braisted S. Panno | 2006 | Journal of Radioanalytical and Nuclear Chemistry2006，，3： | 1 |
| 17 | Hydrochemistry of the MahometBedrock Valley Aquifer,East-Central Illinois:Indicators of Recharge andGroundWater Flow显示文摘 | Panno S V Hackley K C Cartwright K | 1994 | Ground Water1994，32，4： | 1 |
| 18 | Mid-term results of complex distal humeral fractures显示文摘 | Marco Frattini Giovanni Soncini Maurizio Corradi Bruno Panno Silvio Tocco Francesco Pogliacomi | 2011 | MUSCULOSKELETAL SURGERY2011，，3： | 1 |
| 19 | Exergy recovery during LNG regasification: Electric energy production – Part two显示文摘 | Celidonio Dispenza Giorgio Dispenza Vincenzo La Rocca Giuseppe Panno | 2008 | Applied Thermal Engineering2008，，2： | 1 |
| 20 | Insulin can modulate MCF-7 cell response to pacfitaxel显示文摘 | Miglietta A Panno ML Bozzo F | 2004 | Cancer Lett2004，209，2： | 1 |
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