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13篇 您的检索式:作者名="Pallandre"
    题名 作者 年代 出处 被引量
1Neuropilin-2 expression promotes TGF-131-mediated epithelial to mesenchymal transition in colorectal cancer cells 显示文摘Grandclement C Pallandre JR Valmary Deqano S 2011PLoS One2011,6,20:1
2Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity 显示文摘Pallandre JR Brillard E Crehange G 2007JImmunol2007,179,11:1
3Lamination-- Based Rapid Prototyping of Microfluidic Devices Using Flexible Thermoplastic Substrates显示文摘Paul D Pallandre A Miserere S 2007Electrophoresis2007,28,7:1
4Role of STAT3 in CD4^+CD25 ^+ FOXP3^+ Regulatory Lymphocyte Generation: Implications in Graft- versus-Host Disease and Antitumor Immunity 显示文摘Pallandre J R Brillard E Cr6hange G 2007Immunology2007,179,11:1
5Ionic and mass transport in miero-nanofluidic de- vices: A matter of volumic surface charge显示文摘PLECIS A PALLANDRE A HAGHIRI-GOSNET A M 2011Lab on a Chip-Miniaturisation for Chemistry and Biology2011,11,5:1
6Neuropilin-2expression promotes IGF- p 1 -mediated epithelial to mes-enchymal transition in colorectal cancer cells 显示文摘Grandclement C Pallandre J R Valmary D S 2011PLoS One2011,6,20:1
7Neuropilin-2 expression promotes TGF-131- mediated epithelial to mesenchymal transition in colorectal cancer cells 显示文摘GRANDCLEMENT C PALLANDRE JR VALMARY DEG- ANO S 2011PLoS One2011,6,20:1
8Neuropilin-2 expression promotes TGF-b I-mediated epithelial to mesenehymal transitinn in coloreetal cancer cells显示文摘Grandclement C Pallandre JR Valmary 1)egano S 2011PLoS One2011,6,20:1
9Recent innovations in protein separation on microchips by electrophoretic methods显示文摘PENG Y PALLANDRE A TRAN N T 2008Electrophoresis2008,29,1:1
10Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation:implications in graft-versus-host disease and antitumor immunity显示文摘Pallandre JR Brillard E Créhange G 0,,:1
11Natural killer ceils prevent CD28-mediated Foxp3 transcription in CD4 + CD25- T lymphocytes显示文摘Brillard E Pallandre JR Chalmers D 2007Exp Hematol2007,35,3:1
12Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1α are associated with ascending aorta aneurysm size显示文摘Eric Parietti Jean-René Pallandre Frederic Deschaseaux Bertrand Aupè cle Camille Durst Jean-Pierre Kantelip Sidney Chocron Siamak Davani 2011European Journal of Cardio-Thoracic Surgery2011,,1:1
13CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery显示文摘CD226 has been reported to participate in the rescue of CD8^(+)T cell dysfunction.In this study,we aimed to assess the prognostic value of CD226 in tumor-infiltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical surgery.TILs from 43 metastases were isolated and analyzed ex vivo usingflow cytometry.CD155 and CD3 levels in the tumor microenvironment were assessed by immunohistochemistry.Exploration and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression datasets.CD226 expression contributes to the definition of the immune context in CRC liver metastases and primary tumors.CD226 on CD8^(+)T cells was not specifically coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver metastases.Multivariate Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of CD226.Gene expression analysis in a validation dataset confirmed the prognostic value of CD226 in CRC liver metastases but not in primary tumors.Downregulation of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 treatment.Overall,CD226 expression on liver metastasis-infiltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe Borg Marie Kroemer 2023Cellular & Molecular Immunology2023,20,4:0
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