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| 1 | New technologies to investigate the brain-gut axis显示文摘Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology. Knowledge of how the brain processes sensory information from visceral structures is still in its infancy. However, our understanding has been propelled by technological imaging advances such as functional Magnetic Resonance Imaging, Positron Emission To-mography, Magnetoencephalography, and Electroen-cephalography (EEG). Numerous human studies have non-invasively demonstrated the complexity involved in functional pain processing, and highlighted a number of subcortical and cortical regions involved. This review will focus on the neurophysiological pathways (primary afferents, spinal and supraspinal transmission), brain- imaging techniques and the influence of endogenous and psychological processes in healthy controls and patients suffering from functional gastrointestinal dis- orders. Special attention will be paid to the newer EEG source analysis techniques. Understanding the pheno- typic differences that determine an individual's response to injurious stimuli could be the key to understanding why some patients develop pain and hyperalgesia in response to inflammation/injury while others do not. For future studies, an integrated approach is required incorporating an individual's psychological, autonomic, neuroendocrine, neurophysiological, and genetic prof ile to def ine phenotypic traits that may be at greater risk of developing sensitised states in response to gut in? am- mation or injury. | Abhishek Sharma Dina Lelic Christina Brock Peter Paine Qasim Aziz | 2009 | World Journal of Gastroenterology2009，15，2： | 15 |
| 2 | Assessment of the Bemisia tabaci C YP6CM l vQ transcript and protein levels in laboratory and field-derived imidacloprid-resistant insects and cross-metabolism potential of the recombinant enzyme显示文摘 | Emmanouil Roditakis Evangelia Morou Anastasia Tsagkarakou Maria Riga Ralf Nauen Mark Paine Shai Morin John Vontas | 2011 | Insect Science2011，18，1： | 7 |
| 3 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 4 | Modelling of massive particulates for breakwater engineering using coupled FEMDEM and CFD显示文摘The seaward slope of many breakwaters consists of thousands of interlocking units of rock or concrete comprising a massive granular system of large elements each weighing tens of tonnes. The dumped quarry materials in the core are protected by progressively coarser particulates. The outer armour layer of freely placed units is intended to both dissipate wave energy and remain structurally stable as strong flows are drawn in and out of the particulate core. Design guidance on the mass and shape of these units is based on empirical equations derived from scaled physical model tests. The main failure mode for armour layers exposed to severe storms is hydraulic instability where the armour units of concrete or rock are subjected to uplift and drag forces which can in turn lead to rocking, displacement and collisions sufficient to cause breakage of units. Recently invented armour unit designs making up such granular layered system owe much of their success to the desirable emergent properties of interlock and porosity and how these combine with individual unit structural strength and inertial mass. Fundamental understanding of the forces governing such wave-structure interaction remains poor. We use discrete element and combined finite-discrete element methods to model the granular solid skeleton of randomly packed units coupled to a CFD code which resolves the wave dynamics through an interface tracking technique. The CFD code exploits several methods including a compressive advection scheme, node movement, and general mesh optimization. We provide the engineering context and report progress towards the numerical modelling of instability in these massive granular systems. | John-Paul Lathama Antonio Munjiza Julian Mindel Jiansheng Xiang Romain Guises Xavier Garcia Chris Pain Gerard Gorman Matthew Piggott | 2008 | Particuology2008，6，6： | 5 |
| 5 | Spinal processing of bee venom-induced pain and hyperalgesia显示文摘Subcutaneous injection of bee venom causes long-term neural activation and hypersensitization in the dorsal horn of the spinal cord,which contributes to the development and maintenance of various pain-related behaviors.The unique behavioral 'phenotypes' of nociception and hypersensitivity identified in the rodent bee venom test are believed to reflect a complex pathological state of inflammatory pain and might be appropriate to the study of phenotype-based mechanisms of pain and hyperalgesia.In this review,the spinal processing of the bee venom-induced different 'phenotypes' of pain and hyperalgesia will be described.The accumulative electrophysiological,pharmacological,and behavioral data strongly suggest that different 'phenotypes' of pain and hyperalgesia are mediated by different spinal signaling pathways.Unraveling the phenotype-based mechanisms of pain might be useful in development of novel therapeutic drugs against complex clinic pathological pain. | Jun CHEN Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,the Fourth Military Medical University,Xi’an 710038,China Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China | 2008 | 生理学报2008，60，5： | 3 |
| 6 | Artificial Neural Network (ANN) and Regression Tree (CART) applications for the indirect estimation of unsaturated soil shear strength parameters显示文摘土壤(内部磨擦的结合和角度) 的 shear 强度参数在解决许多土木工程问题是相当必要的。以便决定这些参数,实验室测试被使用。这个工作的主要目的是为这些参数的间接评价评估人工的神经网络(ANN ) 和回归树(大车) 技术的潜力。就 6 输入的不同联合而言,例如石子 % ,沙 % ,淤泥 % ,泥土 % ,干燥密度,和粘性索引,四个不同模型被调查在预言上评估他们的效果的度砍参数。表演评估用关联系数和根均方差措施被执行。这被观察为磨擦角度的预言,两个的表演这些技术关于一样。为结合的预言,然而, ANN 技术比 CART 技术更好表现。6 个输入土壤参数的就所有而言的模型是为预言的最适当的模型,这进一步被观察砍参数。另外,连接重量和偏爱最好的神经网络分析(即, 6/2/2 ) 用连接重量, Garson,和描绘输入变量的影响在上的建议重量偏爱途径被尝试砍力量参数。连接重量途径为精确地确定提供最好的全面方法论,这被观察可变重要性,并且应该在在这研究检验的另外的途径上被赞成。 | D.P. KANUNGO Shaifaly SHARMA Anindya PAIN | 2014 | Frontiers of Earth Science2014，8，3： | 3 |
| 7 | Optimal Contraction Intensity During Proprioceptive Neuromuscular Facilitation for Maximal Increase of Range of Motion显示文摘 | Peter W Sheard Tim J Paine | 2010 | Journal of Strength and Conditioning Research2010，，2： | 2 |
| 8 | Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential显示文摘 | Ananta Paine Britta Eiz-Vesper Rainer Blasczyk Stephan Immenschuh | 2010 | Biochemical Pharmacology2010，，： | 2 |
| 9 | 现行中国石油行业管理体制法律研究显示文摘中国石行业经过半个多世纪的发展,行业整体实力不断增强。相对低级别的分散管理体制面临挑战。政府管理石油行业主要基于四个目的:消费者利益,供给保证(经济安全),国家安全和环境保护。十二五转轨阶段,政策趋向和立法态度趋向于结构调整,战略储备建设,管道保护和安全防范等方面。 | 潘佳 Thompson Paine | 2011 | 商场现代化2011，，3： | 2 |
| 10 | A simplified approach to assess seismic stability of tailings dams显示文摘In the zones of high seismic activity, tailings dam should be assessed for the stability against earthquake forces. In the present paper, a simplified method is proposed to compute the factor of safety of tailings dams. The strain-dependent dynamic properties are used to assess the stability of tailings dams under seismic conditions. The effect of foundation soil properties on the seismic stability of tailings dams is studied using the proposed method. For the given input parameters, the factor of safety for lowfrequency input motions is nearly 26% lower than that for high-frequency input excitations. The impedance ratio and the depth of foundation have significant effect on the seismic factor of safety of tailings dams. The results from the proposed method are well compared with the existing pseudo-static method of analysis. Tailings dams are vulnerable to damage for low-frequency input motions. | Sanjay Nimbalkar V.S.Ramakrishna Annapareddy Anindya Pain | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，6： | 2 |
| 11 | 天然气水合物稳定带内流体压裂计算的程序耦合方法显示文摘海洋天然气水合物稳定带气烟囱结构中存在被水合物充填的裂隙,表明在自然条件下沉积物中曾发生过流体压裂以及相关的流体流动和水合物形成。在水合物稳定带内实施人为的流体压裂工程,并联合其他方法(如降压或注热)进行水合物开采,有望提高开采效率。水合物稳定带内,无论是自然条件下发生的流体压裂过程,还是人为实施的流体压裂工程,都存在水合物反应和沉积物裂隙变形之间的耦合响应。当前,已有不少数值程序对水合物反应与沉积物弹塑性变形的耦合过程进行了定量研究,但尚没有数值程序能够计算水合物反应和离散裂隙变形之间的耦合过程。文章将TOUGH+Hydrate程序、IC-FERST和Solidity两者的耦合程序进行了进一步耦合,为水合物稳定带内的流体压裂计算提供了一种耦合计算方法,同时通过一个算例初步验证了该耦合计算方法的可行性。验证结果表明,该耦合计算方法经进一步改进后有望应用于定量研究水合物稳定带内的裂隙变形和水合物反应过程。 | 刘金龙 王淑红 Asiri Obeysekara XIANG Jiansheng Pablo Salinas Christopher Pain Jonny Rutqvist 颜文 | 2020 | 热带海洋学报2020，39，1： | 2 |
| 12 | Seismic passive earth resistance using modified pseudo-dynamic method显示文摘In earthquake prone areas,understanding of the seismic passive earth resistance is very important for the design of different geotechnical earth retaining structures.In this study,the limit equilibrium method is used for estimation of critical seismic passive earth resistance for an inclined wall supporting horizontal cohesionless backfill.A composite failure surface is considered in the present analysis.Seismic forces are computed assuming the backfill soil as a viscoelastic material overlying a rigid stratum and the rigid stratum is subjected to a harmonic shaking.The present method satisfies the boundary conditions.The amplification of acceleration depends on the properties of the backfill soil and on the characteristics of the input motion.The acceleration distribution along the depth of the backfill is found to be nonlinear in nature.The present study shows that the horizontal and vertical acceleration distribution in the backfill soil is not always in-phase for the critical value of the seismic passive earth pressure coefficient.The effect of different parameters on the seismic passive earth pressure is studied in detail.A comparison of the present method with other theories is also presented,which shows the merits of the present study. | Anindya Pain Deepankar Choudhury S. K. Bhattacharyya | 2017 | Earthquake Engineering and Engineering Vibration2017，16，2： | 2 |
| 13 | 非结构网格空气质量模式对东亚强沙尘暴的初步模拟研究显示文摘基于中国科学院大气物理研究所自主研发的嵌套网格空气质量数值预报模式(NAQPMS)和英国帝国理工学院应用计算与建模小组(AMCG)研制的有限元流体模式(Fluidity),构建了非结构网格沙尘传输模式(Fluidity-Dust),并模拟再现了2010年3月19-22日东亚强沙尘暴整个暴发、演变的三维立体动态过程,从整体上对这次沙尘事件有了全新的直观认识和了解。通过利用FY-2D卫星沙尘反演资料及MODIS(Moderate Resolution Imaging Spectroradiometer)卫星反演的气溶胶光学厚度(AOD)资料,可对模拟结果进行整体上对比验证;同时,利用中国9个城市站点的PM10(空气动力学当量直径小于等于10μm的颗粒物,即可吸入颗粒物)地面观测资料以及日本多个站点的激光雷达资料,逐一对比分析了不同地区PM10的时空分布以及沙尘传输经过时的垂直分布情况;并与NAQPMS模式的沙尘模拟结果进行了模式间的对比分析。对比结果均表明:该模式具有较好的模拟能力,能很好地模拟再现整个沙尘暴过程,为今后进一步运用自适应变网格技术以实现对沙尘暴的高精度追踪模拟奠定了基础。不同模式比较是量化模拟不确定性的重要方法。以往沙尘输送模式比较研究表明:起沙量模拟的不确定性是沙尘暴数值模拟的最大不确定来源。本文通过两个具有相同起沙方案的模式对同一沙尘事件的模拟,发现不同的平流方案以及不同的沉降计算也会对沙尘过程模拟产生重要影响。 | 郑捷 王自发 朱江 李杰 FANG F PAIN C C | 2016 | 气候与环境研究2016，21，6： | 2 |
| 14 | Protein folding and its implications for the production of recombinant proteins 显示文摘 | Hlodan R Craig S Pain RH | 1991 | Biotech Genet Eng Rev1991，9，： | 2 |
| 15 | Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management 显示文摘 | American Society of Anesthesiologists Task Force on Acute Pain Management | 2004 | Anesthesiology2004，100，6： | 1 |
| 16 | Opening mitochondiral KATP channels triggers the preconditioned state by generating free radicals 显示文摘 | Pain T Yang XM Critz SD | 2000 | Cire Res2000，87，： | 1 |
| 17 | Design of symmetric conic-section flexure hinges based on closed-form compliance equations显示文摘 | Nicolae Lobontiu Jeffrey S N Paine Ephrahim Garcia | 2002 | Mechanism and Machine Theory2002，37，： | 1 |
| 18 | Learning to Teach with Mandated Curriculum and Public Examination of Teaching as Contexts 显示文摘 | Wang J Paine L | 2003 | Teaching and Teacher Education2003，19，： | 1 |
| 19 | Long-term in vitro culture and characterization of avian embryonic stem cells with multiple morphogenetic potentialities显示文摘 | Pain B Clark ME Shen M | 1996 | Development1996，122，： | 1 |
| 20 | Urinary inositol phos- phoglycan P-type as a marker for prediction of preeclampsia and novel implications for the pathophysiology of this disor- der显示文摘 | Paine MA Scioscia M Williams PJ | 2010 | Hypertens Pregnancy2010，29，4： | 1 |
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