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| 1 | Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies显示文摘Coronaviruses are enveloped,positive-stranded RNA viruses that contain the largest known RNA genomes to date.As severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to circulate in the human population,multiple mutations have accumulated over time,which may affect its transmission,virulence and antigenicity. | Jie Hu Pai Peng Kai Wang Liang Fang Fei-yang Luo Ai-shun Jin Bei-zhong Liu Ni Tang Ai-long Huang | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | Increased immune escape of the new SARS-CoV-2 variant of concern Omicron显示文摘On 24 November,a new detected variant B.1.1.529 of SARS-CoV-2 by South Africa was reported to WHO.After only 2 days,this variant was designated as“variant of concern”(VOC)and named as Omicron.In the past few weeks,Omicron had reported from more than 80 countries.It has been reported as the dominant SARS-CoV-2 in U.S.due to the rapid spread of Omicron.A new wave of infection driven by Omicron is in progress. | Jie Hu Pai Peng Xiaoxia Cao Kang Wu Juan Chen Kai Wang Ni Tang Ai-long Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 4 |
| 3 | Spontaneous T-symmetry breaking and exceptional points in cavity quantum electrodynamics systems显示文摘Spontaneous symmetry breaking has revolutionized the understanding in numerous fields of modern physics. Here, we theoretically demonstrate the spontaneous time-reversal symmetry breaking in a cavity quantum electrodynamics system in which an atomic ensemble interacts coherently with a single resonant cavity mode. The interacting system can be effectively described by two coupled oscillators with positive and negative mass, when the two-level atoms are prepared in their excited states. The occurrence of symmetry breaking is controlled by the atomic detuning and the coupling to the cavity mode,which naturally divides the parameter space into the symmetry broken and symmetry unbroken phases.The two phases are separated by a spectral singularity, a so-called exceptional point, where the eigenstates of the Hamiltonian coalesce. When encircling the singularity in the parameter space, the quasiadiabatic dynamics shows chiral mode switching which enables topological manipulation of quantum states. | Yu-Kun Lu Pai Peng Qi-Tao Cao Da Xu Jan wiersig Qihuang Gong Yun-Feng Xiao | 2018 | Science Bulletin2018，63，17： | 4 |
| 4 | Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months显示文摘Many countries around the world have seen a sharp rise in COVID-19 cases since the beginning of October due to the second wave of the pandemic.A decline in the antibody response to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which was reported exclusively in the early month,increases the risk of reinfection for convalescent individuals.There is a current need to follow the maintenance of specific antibodies against SARS-CoV-2. | Pai Peng Jie Hu Hai-jun Deng Bei-zhong Liu Liang Fang Kai Wang Ni Tang Ai-long Huang | 2021 | Cellular & Molecular Immunology2021，18，2： | 4 |
| 5 | Fabrication and electrical characteristics of flash-sintered SiO_(2)-doped ZnO-Bi_(2)O_(3)-MnO_(2) varistors显示文摘The dense ZnO-Bi_(2)O_(3)-MnO_(2)(ZBMS)varistors for x=0,1,2,3 wt% were fabricated by flash sintering method under the low temperature of 850℃ within 2 min.The sample temperature was estimated by a black body radiation model in the flash sintering process.The crystalline phase assemblage,density,microstructure,and electrical characteristics of the flash-sintered ZBMS varistors with different SiO_(2)-doped content were investigated.According to the XRD analysis,many secondary phases were detected due to the SiO_(2) doping.Meanwhile,the average grain size decrease with increasing SiO_(2)-doped content.The improved nonlinear characteristics were obtained in SiO_(2)-doped samples,which can be attributed to the ion migration and oxygen absorption induced by the doped SiO_(2).The flash-sintered ZBMS varistor ceramics for x=2 wt% exhibited excellent comprehensive electrical properties,with the nonlinear coefficient of 24.5,the threshold voltage and leakage current of 385 V·mm^(-1 )and 11.8μA,respectively. | Pai PENG Yujun DENG Jingpeng NIU Liyi SHI Yunzhu MEI Sanming DU Juan LIU Dong XU | 2020 | Journal of Advanced Ceramics2020，9，6： | 3 |
| 6 | Smart additive manufacturing: Current artificial intelligenceenabled methods and future perspectives显示文摘Additive manufacturing(AM) has been increasingly used in production. Because of its rapid growth, the efficiency and robustness of AM-based product development processes should be improved. Artificial intelligence(AI) is a powerful tool that has outperformed humans in numerous complex tasks. AI-enabled intelligent agents can reduce the workforce required to scale up AM production and achieve higher resource utilization efficiency. This study provides an introduction of AI techniques. Then,the current development of AI-enabled AM product development is investigated. Existing intelligent agents are used for problems in product design, process design and production stages. Based on the review, current research gaps and future research directions are identified. To guide future development of more efficient and comprehensive intelligent agents, a smart AM framework based on cloud-edge computing is proposed. Global consideration can be realized in the cloud environment, and a fast response can be achieved at the edge nodes. | WANG YuanBin ZHENG Pai PENG Tao YANG HuaYong ZOU Jun | 2020 | Science China(Technological Sciences)2020，63，9： | 2 |
| 7 | Achieving Safe Deep Reinforcement Learning via Environment Comprehension Mechanism显示文摘Deep reinforcement learning(DRL), which combines deep learning with reinforcement learning, has achieved great success recently. In some cases, however,during the learning process agents may reach states that are worthless and dangerous where the task fails. To address the problem, we propose an algorithm, referred as Environment comprehension mechanism(ECM) for deep reinforcement learning to attain safer decisions. ECM perceives hidden dangerous situations by analyzing object and comprehending the environment, such that the agent bypasses inappropriate actions systematically by setting up constraints dynamically according to states. ECM, which calculates the gradient of the states in Markov tuple, sets up boundary conditions and generates a rule to control the direction of the agent to skip unsafe states. ECM is able to be applied to basic deep reinforcement learning algorithms to guide the selection of actions. The experiment results show that the algorithm promoted safety and stability of the control tasks. | PENG Pai ZHU Fei LIU Quan ZHAO Peiyao WU Wen | 2021 | Chinese Journal of Electronics2021，30，6： | 2 |
| 8 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 9 | Isolation of bacteria with antibiotic resistance from household cockroaches (Periplaneta americana and Blattella germanica)显示文摘 | PAI H H CHEN W C PENG C F | 2005 | Acta Trop2005，93，3： | 1 |
| 10 | The impacts of continuous veno-venous hemofiltration on plasma cytokines and monocyte human leukocyte antigen-DR expression in septic patients显示文摘 | Peng Z Pai P Hong-Bao L | 2010 | Cytokine2010，50，2： | 1 |
| 11 | Degradation and Transformation of Atrazine Under Catalyzed Ozonation Process with TiO2 as Catalyst 显示文摘 | YANG Yi-xin CAO Hong-bin PENG Pai | 2014 | Journal of Hazardous Materials2014，279，： | 1 |
| 12 | The impacts of continuous veno-venoushemofiltration on plasma cytokines and monocyte human leukocyteantigen-DRexpression in septic patients显示文摘 | Peng Z Pai P Hong BL | 2010 | Cytokine2010，50，2： | 1 |
| 13 | Evaluation of the effects ofpulse high - volume hemofiltration in patients with severe sepsis : apreliminary study显示文摘 | Peng Z Pai P Han Min W | 2010 | Int J Artif Organs2010，33，8： | 1 |
| 14 | Thermomechanical finite-element analysis and dynamics characterization of three-plug oscilla- ting heat pipes 显示文摘 | Pai P F Peng H Ma H | 2013 | International Journal of Heat and Mass Transfer2013，64，： | 1 |
| 15 | STX5 Inhibits Hepatocellular Carcinoma Adhesion and Promotes Metastasis by Regulating the PI3K/mTOR Pathway显示文摘Background and Aims:Syntaxin 5(STX5)is a member of the syntaxin or target-soluble SNAP receptor(t-SNARE)fam-ily and plays a critical role in autophagy.However,its function and molecular mechanism in tumor cell migration are still un-known.The role of STX5 in influencing hepatocellular carci-noma(HCC)is an important topic in our research.Methods:By using quantitative reverse transcription polymerase chain reaction(qPCR),western blotting,and immunohistochemical analysis of RNA and protein in tissues,we comprehensively evaluated data sets from public databases and clinical patient cohorts for STX5.The correlation of STX5 expression with the clinicopathological characteristics of HCC patients were assessed.In addition,we predicted signal pathways from dif-ferentially expressed genes(DEGs)and the Cancer Genome Atlas(TCGA)databases,and confirmed the prediction using integrated transcriptome and RNA-seq.We further investi-gated the underlying mechanisms of STX5 in the migration and adhesion of HCC cells both in vitro and in vivo.Results:In the TCGA dataset and our patient cohort,STX5 levels were significantly higher in HCC tissues than in adjacent normal liver tissues.At the same time,high expression of STX5 pre-dicted worse prognosis in patients with liver cancer.High ex-pression of STX5 indicates the decrease of adhesion and the increase of migration of HCC cells,and the conversion of epi-thelial-mesenchymal transition(EMT)in vitro via PI3K/mTOR pathway activation.Conversely,when Sirolimus,a phospho-inositide 3-kinase(PI3K)/AKT/mechanistic target of rapa-mycin(mTOR)inhibitor acts on cells simultaneously,STX5 overexpression-mediated enhancement of HCC metastasis is reversed.Double-negative regulation of STX5 and mTOR further enhanced the inhibitory effect of STX5 on HCC me-tastasis.In vivo,STX5 knockdown inhibited the metastasis of HCC cells.Conclusions:Our study demonstrates a novel research result that STX5 promotes HCC metastasis through PI3K/mTOR pathway.We believe that combined inhibition of STX5 and mTOR is a potential treatment for effectively pro-longing patient survival and inhibiting HCC metastasis. | Bin Zhang Ziyin Zhao Youpeng Wang Tingting Guo Mingyang He Ge Guan Pai Peng Jinzhen Cai Bingyuan Zhang Xutao Liu Qiaoling Song | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 16 | Isolation of bacteria with antibiotic resistance from household cockroaches (Periplaneta americana and Blattelia germanica)显示文摘 | Pai HH Chen WC Peng CF | 2005 | Acta Trop2005，93，3： | 1 |
| 17 | Isolation and fractionation of hemicelluloses by graded ethanol precipitation from Caragana korshinskii 显示文摘 | JING BIAN FENG PENG PAI PENG | 2010 | Carbohy- drate Research2010，345，6： | 1 |
| 18 | Influence of relative hypparath- yr0idismon the responsiveness to recombinant human erythropoietin in hemodialysis patients 显示文摘 | Hsu SP Peng YS Pai MF | 2003 | Blood Puri2003，，21： | 1 |
| 19 | Evaluation of the effects of pulse high- volume hemofihration in patients with severe sepsis:a preliminary study 显示文摘 | Peng Z Pai P Han- Min W | 2010 | Int J Artif Organs2010，33，8： | 1 |
| 20 | Isolation of bacteria with antibiotic resistance from household cockroaches (Periplaneta americana and Blattella germanica) 显示文摘 | Pai H H Chen W C Peng C F | 2005 | Acta Trop2005，93，3： | 1 |
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