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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Prevention of rifampicin resistance in Acinetobacter bau-mannii in an experimental pneumonia murine model,usingrifampicin associated with imipenem or sulbactam显示文摘 | Pachón-Ibáez ME Fernández-Cuenca F Docobo-Pérez F etal | 2006 | J Anti-microb Chemother2006，58，3： | 1 |
| 3 | When Worlds Collide: The Internal Dynamics of Organizational Responses to Conflicting Institutional Demands 显示文摘 | PACHE A SANTOS F | 2010 | Academy of Management Review2010，35，3： | 1 |
| 4 | Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3显示文摘 | Meixenberger K Pache F Eitel J | 2010 | J Immunol2010，184，2： | 1 |
| 5 | Inside the hybrid organization: se- lective coupling as a response to competing institutional logics 显示文摘 | Pache A C Santos F | 2013 | Academy of Management Journal2013，56，4： | 1 |
| 6 | Inside the Hybrid Organiza- tion: Selective Coupling As A Response To Compe- ting Institutional Logics 显示文摘 | Pache A Santos F | 2013 | Academy of Manage- ment Journal2013，56，4： | 1 |
| 7 | Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1 beta, depending on listeriolysin O and NLRP3 显示文摘 | Meixenberger K Pache F Eitel J | 2010 | J Immunol2010，184，2： | 1 |
| 8 | Growth patterns of nondominant ovarian follicles during the normal menstrual cycle显示文摘 | Pache T Wladimiroff J DeJong F | 1990 | Fertil Steril1990，54，： | 1 |
| 9 | Growth patterns of non dominant ovarian follicles during the normal menstrual cycle显示文摘 | Pache T Wladimiroff J DeJong F | 1990 | Fertil Steril1990，54，： | 1 |
| 10 | Luteal function following ovulation induction in polycystic ovary syndrome patients using exogenous gonadotrophins in combination with a gonadotrophin-releasing hormone agonist显示文摘 | Donderwinkel P F Schoot D C Pache T D | 1993 | Hum Reprod1993，8，12： | 1 |
| 11 | The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia显示文摘 | Witzenrath M Pache F Lorenz D | | 0，，： | 1 |
| 12 | Airborne particulate matter around the Cathedral of Burgos 显示文摘 | Esber R M Diaz Pache F Grossi C M | 2001 | Atmospheric Environment2001，35，2： | 1 |
| 13 | Strategy dynamics in the logistics industry: a transactional center perspective 显示文摘 | Fulconis F Saglietto L Pache G | 2007 | Management Decision2007，45，1： | 1 |
| 14 | Listeria monocytogenesinfected human peripheral biood mononuclear cells produce IL- 1 hera, depending on listeriolysin O and NLRP3 显示文摘 | Meixenberger K Pache F Eitel J et at | 2010 | J Immunol2010，184，2： | 1 |
| 15 | Three-year multicenter surveillance of community-acquired Listeria monocytogenes meningitis in adults显示文摘 | Amaya-Villar R García-Cabrera E Sulleiro-Igual E Fernández-Viladrich P Fontanals-Aymerich D Catalán-Alonso P Rodrigo-Gonzalo de Liria C Coloma-Conde A Grill-Díaz F Guerrero-Espejo A Pachón J Prats-Pastor G | 2010 | BMC Infect Dis2010，10，： | 1 |
| 16 | Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia murine model,using rifampicin associated with imipenem or sulbactam显示文摘 | Pachón-Ibánez ME Fernández-Cuenca F Docobo-Pérez F | 2006 | Journal Antimicrob Chemother2006，58，3： | 1 |
| 17 | When worlds collide:The internal dynamics of organizational responses to conflicting institu- tional demands 显示文摘 | Pache A C Santos F M | 2010 | Academy of Management Review2010，35，3： | 1 |
| 18 | Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3显示文摘 | Meixenberger K Pache F Eitel J | 2010 | J Immunol2010，184，2： | 1 |
| 19 | Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia murine model,using rifampicin associated with imipenem or sulbactam显示文摘 | Pachón-Ibá(n)ez ME Fernández-Cuenca F Docobo-Pérez F | 2006 | J Antimicrob Chemother2006，58，3： | 1 |
| 20 | Insider the hybrid organization: an organizational level view of responses to conflicting institutional demands 显示文摘 | Pache A C Santos F | 2013 | Academy of Management Journal2013，56，4： | 1 |
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