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| 1 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Subcutaneous implantable defibrillator: State-of-the art 2013显示文摘The subcutaneous implantable cardioverter-defibrillator(S-ICD)has recently been approved for commercial use in Europe,New Zealand and the United States.It is comprised of a pulse generator,placed subcutaneously in a left lateral position,and a parasternal subcutaneous lead-electrode with two sensing electrodes separated by a shocking coil.Being an entirely subcutaneous system it avoids important periprocedural and long-term complications associated with transvenous implantable cardioverter-defibrillator(TV-ICD)systems as well as the need for fluoroscopy during implant surgery.Suitable candidates include pediatric patients with congenital heart disease that limits intracavitary lead placements,those with obstructed venous access,chronic indwelling catheters or high infection risk,as well as young patients with electrical heart disease(e.g.,Brugada Syndrome,long QT syndrome,and hypertrophic cardiomyopathy).Nevertheless,given the absence of intracavitary leads,the S-ICD is unable to offer pacing(apart from shortterm post-shock pacing).It is therefore not suitable in patients with an indication for antibradycardia pacing or cardiac resynchronization therapy,or with a history of repetitive monomorphic ventricular tachycardia that would benefit from antitachycardia pacing.Current data from initial clinical studies and post-commercialization'real-life'case series,including over 700 patients,have so far been promising and shown that the S-ICD successfully converts induced and spontaneous ventricular tachycardia/ventricular fibrillation episodes with associated complication and inappropriate shock rates similar to that of TV-ICDs.Furthermore,by using far-field electrograms better tachyarrhythmia discrimination when compared to TV-ICDs has been reported.Future results from ongoing clinical studies will determine the S-ICD system’s long-term performance,and better define suitable patient profiles. | Finn Akerstrm Miguel A Arias Marta Pachón Alberto Puchol Jesús Jiménez-Lópezl | 2013 | World Journal of Cardiology2013，5，9： | 2 |
| 4 | lntracoronary stentlng and angiographic results : strut thickness effect on restenosis outcome ( ISAR-STEREO-2 ) trial 显示文摘 | Pache J Kastrati A MehiUi J | 2003 | J Am Coll Cardiol2003，41，8： | 1 |
| 5 | When Worlds Collide: The Internal Dynamics of Organizational Responses to Conflicting Institutional Demands 显示文摘 | PACHE A SANTOS F | 2010 | Academy of Management Review2010，35，3： | 1 |
| 6 | Clopido- grel therapy in patients undergoing coronary stenting:value of a high - loading - dose regimen 显示文摘 | Pache J Kastrati A Mehilli J | 2002 | Catheter Cardiovasc Interv2002，55，： | 1 |
| 7 | Analysis of 14 trials comparing sirolimuseluting stents with bare-metal stents 显示文摘 | Kastrati A Mehilli J Pache J | 2007 | N Engl J Med2007，356，： | 1 |
| 8 | Analysis of 14 trials comparing sirolimus- eluting stents with bare-metal stents显示文摘 | Kastrati A Mehilli J Pache J | 2007 | N Engl J Med2007，356，： | 1 |
| 9 | Inside the hybrid organization: se- lective coupling as a response to competing institutional logics 显示文摘 | Pache A C Santos F | 2013 | Academy of Management Journal2013，56，4： | 1 |
| 10 | hatial experience with 64- slice cardiac CT: non-invasive visualization of coronary artery bypass grafts 显示文摘 | Pache G Saueressig U Frydrychowicz A | 2006 | Eur Heart J2006，27，8： | 1 |
| 11 | Comparison of reconstruction intervals in routine ECG-pulsed 64-row-MSCT coronary angiography in frequency controlled patients显示文摘 | Frydrychowicz A Pache G Saueressig U | 2007 | Cardiovasc Intervent Radiol2007，30，1： | 1 |
| 12 | Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents 显示文摘 | Kastrati A Mehilli J Pache J | 2007 | N Engl J Med2007，356，10： | 1 |
| 13 | Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents显示文摘 | Kastrati A Mehilli J Pache J | 2007 | N Engl J Med2007，356，10： | 1 |
| 14 | Self-assembly of ZnO: From nanodots to nanorods显示文摘 | PACH C KORNOWSKI A WELLER H | 2002 | Angew Chem Int Ed2002，1，7： | 1 |
| 15 | Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents 显示文摘 | Kastrati A Mehilli J Pache J | 2007 | N Engl J Med2007，356，10： | 1 |
| 16 | A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy 显示文摘 | Pache J Kastrati A Mehilli J | 2004 | Am Heart J2004，148，1： | 1 |
| 17 | Diabetes mellitus and the clinical and angiographic outcome after coronary stent placement显示文摘 | ELEZI S KASTRATI A PACHE J | 1998 | J Am Coll Cardiol1998，32，7： | 1 |
| 18 | Drug eluting stents compared with thin-strut bare stents for the reduction of restenosis:a prospec- tive,randomized trial显示文摘 | Pache J Dibra A Mehill IJ | 2005 | Eur Heart J2005，26，19： | 1 |
| 19 | Carcinoma arising in congenital lung cysts显示文摘 | Deperrot M Pache JC Spiliopouos A | 2001 | Thorac Cardiovasc Sarg2001，49，： | 1 |
| 20 | Drug eluting stents compared with thin-strut bare stents for the reduction of restenosis:a prospective,randomized trial显示文摘 | Pache J Dibra A Mehilli J et a1 | | 0，，13： | 1 |
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