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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Our experience with 3D CT显示文摘 | Pach M Ditmar R HermanM | 1999 | Acta Aniv Palacki Olomuc Fac Med1999，142，： | 1 |
| 3 | Randomized clinical trial on preoperative radiotherapy 25 Gy in rectal cancer-treatment results at 5-year follow-up显示文摘 | Pach R Kulig J Richter P | 2012 | Langenbecks Arch Surg2012，397，5： | 1 |
| 4 | The history of treatment of groin hernia显示文摘 | Legutko J Pach R Solecki R | 2008 | Folia Med Cracov2008，49，12： | 1 |
| 5 | Varus supracondylar osteotomy of the femur-long-term results显示文摘 | Pach M Uvizl M Holibka R | 2005 | Acta Chir Orthop Traumatol Cech2005，72，6： | 1 |
| 6 | The prevalence by staged severity of various types of diabetic neuropathy,retinopathy,and nephropathy in a population based cohort:the rochester diabetic neuropathy study显示文摘 | Dyck PJ Kratz KM Karnes JL Litchy WJ Klein R Pach JM | 1993 | Neurology1993，43，4： | 1 |
| 7 | A thymoma as a cause of true ectopic hyperparathyroidism显示文摘 | Rizzoli R Pache J C Didierjean L | 1994 | J Clin Endocrinol Metab1994，79，3： | 1 |
| 8 | Renal tubular damage in fetu-ses with intrauterine growth retardation显示文摘 | PachìA Lubrano R Maggi E | 1993 | Fetal Diagn Ther1993，8，2： | 1 |
| 9 | Morphological control of precipitated calcium carbonates and phosphates by colloidal additives显示文摘 | Pach L Duncan S Roy R | 1996 | J Mater Sci1996，31，： | 1 |
| 10 | Identifying HIV-1 host cell factors by genome-scale RNAi screening显示文摘 | Pache L K?nig R Chanda SK | 2011 | Methods2011，53，1： | 1 |
| 11 | Investigating humanitarian logistics issues: from operations management to strategic action显示文摘 | Jér?me Chandes Gilles Paché | 2010 | Journal of Manufacturing Technology Management2010，，3： | 1 |
| 12 | tRNAs in trypanosoma brucei: genomic organization, expression and mitochondrial import 显示文摘 | Pach R Crausaz A | 2002 | Mol Cell Biol2002，22，： | 1 |
| 13 | Effects of a Magnetic Field on the Precipitation of Calcium Carbonate显示文摘 | Duncans R R | 1996 | Journal of Materials Science Letters1996，，15： | 1 |
| 14 | Who controls the placebo? Introducing a placebo quality check list for pharmaco- logical trials显示文摘 | BRINKHAUS B PACH D LUDTKE R | 2008 | Contemp Clin Trials2008，29，2： | 1 |
| 15 | Identifying HIV-1 host cell factors by genome-scale RNAi screening显示文摘 | Pache L Konig R Chanda SK | | 0，，： | 1 |
| 16 | Effects of a magnetic field on the precipitation of calcium carbonate显示文摘 | Pach L Duncans R | 1996 | Journal of Materials Science letters1996，，15： | 1 |
| 17 | The hippocampus as a cognitive graph 显示文摘 | Muller R U Stead M Pach J | 1996 | J Gen Physiol1996，107，6： | 1 |
| 18 | Varus supracondylar osteotomy of the femur-long-term results显示文摘 | Pach M Uvizl M Holibka R | 2005 | Acta Chir Orthop Traumatol Cech2005，72，6： | 1 |
| 19 | Melatonin MT- l-receptor immunoreactivity In the human eye显示文摘 | Meyer P Pache M Loeffler KU Brydon L dockers R Flammer J | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 20 | Airborne particulate matter around the Cathedral of Burgos 显示文摘 | Esber R M Diaz Pache F Grossi C M | 2001 | Atmospheric Environment2001，35，2： | 1 |
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