|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 新型分子靶向药物联合放疗在肺癌中的应用显示文摘非小细胞肺癌(non-small cell lung cancer,NSCLC)约占肺癌总病例数的80%-85%,对于Ⅲ期患者来说,NSCLC约占肺癌总病例数的40%。不可切除Ⅲ期NSCLC的治疗为以铂类为基础的化疗联合胸部放疗。本文将综述正在研发中且有可能用于联合治疗的新型靶向制剂。其中最具前景的策略之一为表皮生长因子受体(epidermal growth factor receptor,EGFR)通路的抑制。放疗可激活EGFR信号,通过诱导细胞增殖并增强DNA修复而导致放疗抵抗。几项临床前模型研究表明西妥昔单抗与放疗联合具有协同效应。几项Ⅱ期试验评估了西妥昔单抗与放疗同步使用的安全性与疗效,结果喜人。吉非替尼对多种细胞系具有放疗增敏作用,其与放疗的联合已被试验用于不可切除Ⅲ期NSCLC的治疗。然而,放化疗后使用吉非替尼作为维持治疗的结果不容乐观。一项Ⅰ期试验评估了厄洛替尼与放化疗联合的疗效。放疗可通过损伤细胞膜、DNA以及微血管内皮细胞而诱导肿瘤死亡,而这反过来可增加促血管生成生长因子的产生。抗血管生长制剂可降低血管密度,但可改善肿瘤的含氧量。应用血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)抑制剂可通过阻断亚致死量辐射损伤的修复而增强放疗对人NSCLC的疗效。厄洛替尼、贝伐珠单抗与胸部放疗联合试验正在进行中。该三种药物联合治疗的新策略尚需制订。由于放疗可增强HSP90分子伴侣的功能从而引起肺癌细胞的放疗抵抗,此通路的阻断剂可通过抑制HIF-1a和VEGF的表达进而抑制肺癌细胞的生存和血管生成,因而可能用于减少放疗抵抗。在NSCLC和间皮瘤的临床前模型中,Aurora激酶抑制剂似乎对放疗具有增效作用。 | Mariano PROVENCIO Antonio SANCHEZ Pilar GARRIDO Francisco VALCARCEL 丁燕 李军 | 2010 | 中国肺癌杂志2010，，8： | 6 |
| 2 | New Molecular Targeted Therapies Integrated With Radiation Therapy in Lung Cancer显示文摘 | Mariano Provencio Antonio Sánchez Pilar Garrido Francisco Valcárcel | 2010 | Clinical Lung Cancer2010，，2： | 2 |
| 3 | Heterogeneous growth of metal clusters from solutions of seed nanoparticles 显示文摘 | WILCOXON J P PROVENCIO P P | 2004 | J Am Chem Soc2004，126，： | 1 |
| 4 | Does the presence of hepatitis virus B and C influence the evolution of diffuse large B-cell lymphoma?显示文摘 | Judit Rubio Fernando Franco Antonio Sá nchez Blanca Cantos Miriam Mé ndez Virginia Calvo Constanza Maximiano David Perez Isabel Millá n Margarita Sá nchez-Beato Mariano Provencio | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 5 | Untrahard carbon nanocomposite films 显示文摘 | Siegal M P Tallant D R Provencio P N | 2000 | Appl Phys Left2000，76，： | 1 |
| 6 | lntracerebral Hemorrhage New Challenges and Steps Forward显示文摘 | Jose Javier Provencio lvan gocha Ferreira Da Silva Edward Michael Manno | 2015 | Neurosurg Clin N Am2015，，24： | 1 |
| 7 | A novel human opsin in the inner retina显示文摘 | Provencio I Rodriguez I R Jiang G | 2000 | J Neurosci2000，20，： | 1 |
| 8 | Optical and electronic properties of Si nanoclusters syn thesized in inverse micelles 显示文摘 | WILCOXON J P SAMARA G A PROVENCIO P N | 1999 | Phys Rev B1999，60，4： | 1 |
| 9 | Retinal ganglion cell projections to the hamster suprachiasmatic nucleus, intergeniculate leaflet, and visual midbrain: bifurcation and melanopsin immunoreactivity 显示文摘 | Morin LP Blanchard JH Provencio I | 2003 | J Comp Neurol2003，465，3： | 1 |
| 10 | Photoreceptive net in the mammalian retina显示文摘 | Provencio I Rollag M D Castruccim A M | 2002 | Nature2002，415，： | 1 |
| 11 | Low-frequency circumferential magnetization curves in magnetostric tive amorphous wires显示文摘 | OLIVERA J PROVENCIO M PRID V M | 2005 | J Magn Magn Mater2005，294，： | 1 |
| 12 | Melanopsin: an opsin in melanophores, brain, and eye 显示文摘 | Provencio I Jiang G De Grip WJ | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，1： | 1 |
| 13 | Ultrahard Carbon Nanocomposite Films显示文摘 | Tallant D R Provencio P N | 2000 | Appl Phys Lett2000，76，： | 1 |
| 14 | Systemic administration of LPS worsens delayed deterioration associated with vasospasm after subarachnoid hemorrhage through a myeloid cell-dependent mechanism显示文摘 | Smithason S Moore SK Provencio JJ | | 0，，02： | 1 |
| 15 | Synthesis of Large Arrays of Well-aligned Carbon Nanotubes On Glass显示文摘 | ZF Ren ZP Huang JW Xu JH Wang P Bush M P Siegal P N Provencio | 1998 | Science1998，282，： | 1 |
| 16 | New molecu- lar targeted therapies imeqrated with radiatian therapy in Lung Cancer 显示文摘 | Provencio M Sanchez A Garrido P | 2010 | Clin Lung Canaer2010，11，1： | 1 |
| 17 | Therapeutic integration of new molecule - targeted therapies with radiotherapy in lung cancer 显示文摘 | Provencio M Senchez A | 2014 | Transl Lung Cancer Res2014，3，2： | 1 |
| 18 | Depletion of Ly6G/C(+)cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage显示文摘 | Provencio JJ Altay T Smithason S | 2011 | J Neuroimmunol2011，232，12： | 1 |
| 19 | Melanopsin retinal ganglion cells receive bipolar and amacrine cell synapses 显示文摘 | Belenky MA Smeraski CA Provencio I | 2003 | J Comp Neurol2003，460，3： | 1 |
| 20 | Cisplatin plus gemcitabine versus a cisplatin-based triplet versus nonplatinum sequential doublets in advanced non-small cell lung cancer:a Spanish Lung Cancer Group phase Ⅲ randomized trial 显示文摘 | Alberola V Camps C Provencio M | 2003 | J Clin Oncol2003，21，17： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员