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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 3 | Prognostic significance of progesterone receptor-positive tumor cells within immunohis- tochemically defined luminal a breast cancer 显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin On- col2013，31，2： | 1 |
| 4 | The biology and therapeutic targeting of the prop- rotein convertases显示文摘 | Seidah NG Prat A | 2012 | Nat Rev Drug Discov2012，11，5： | 1 |
| 5 | Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis 显示文摘 | Thienpont B Tingaud-Sequeira A Prats E | 2011 | Environ Sei Teehnol2011，45，17： | 1 |
| 6 | Lymphocyte migration and multiple sclerosis: relation with disease course and therapy显示文摘 | Prat A AI-Asmi A Duquette P | 1999 | Ann Neurol1999，46，： | 1 |
| 7 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 8 | The blood-brain barrier 显示文摘 | Daneman R Prat A | 2015 | Cold Spring Harb Perspect Biol2015，7，02： | 1 |
| 9 | Extracorporeal high-intensity focused ultrasound for VX2 liver tumors in therabbit显示文摘 | PRAT F CENTARTI M SIBILLE A etal | 1995 | Hepatology1995，21，2： | 1 |
| 10 | Glial cell influence on the human blood-brain barrier显示文摘 | Prat A Biernacki K Wosik K | 2001 | Glia2001，36，： | 1 |
| 11 | Paraquat intoxication显示文摘 | Serra A Domingos F Prat MM | | 0，，： | 1 |
| 12 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Mol Oncol2011，5，1： | 1 |
| 13 | Deconstructing the molecular portraits of breast cancer显示文摘 | PRAT A PEROU C M | 2011 | Molecular Oncology2011，5，1： | 1 |
| 14 | Inflammatory potential and migratory capacities across human brain endothelial cells of distinct glatiramer acetate-reactive T cells generated in treated multiple sclerosis patients显示文摘 | KIM HJ BIERNACKI K PRAT A | 2004 | Clin Immunol2004，111，1： | 1 |
| 15 | Ultrasound-assisted extraction for rapid determination of Zn,Cu,Fe,Mg andMn in liver of diabetic rats under different antioxidant treatments显示文摘 | Prat M L Lopez-Gonzalvez A Ruiz M A | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，49，4： | 1 |
| 16 | The propmtein convertases and their implication in sterol and/or lipid metabolism显示文摘 | Seidah NG Khatib AM Prat A | 2006 | Biol Chern2006，387，87： | 1 |
| 17 | Interpolation-free eoregistration and phase-correction of airborne SAR interferograms显示文摘 | Prats P Reigber A Mallorqui J J | 2004 | IEEE Geoscience Remote Sensing Letters2004，1，3： | 1 |
| 18 | Extrac orporeal ablation of liver tissue by highin tensity focused ultrasound显示文摘 | Sibille A Prat F Chapelon J Y | 1993 | Ontology1993，50，5： | 1 |
| 19 | Conserved MYC transcription factors play a key role in jasmonae signaling both in tomato and Arabidopsis显示文摘 | BOTER M RUIZ-RIVERO O ABDEEN A PRAT S | 2004 | Genes2004，18，： | 1 |
| 20 | Molecular characterization of basal-like and non-basal-like triple-negative breast cancer显示文摘 | Prat A Adamo B Cheang MC | 2013 | Oncologist2013，18，2： | 1 |
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