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| 1 | New approaches in angiogenic targeting for colorectal cancer显示文摘Colorectal carcinoma (CRC) is one of the leading causes of cancer death worldwide. In the last decade, the addition of irinotecan and oxaliplatin to standard fluorouracil-based chemotherapy regimens have set the new benchmark of survival for patients with metastatic CRC at approximately 20 mo. Despite these advances in the management of CRC, there is a strong medical need for more effective and well-tolerated therapies. The dependence of tumor growth and metastasis on blood vessels makes angiogenesis a rational target for therapy. One of the major pathways involved in this process is the vascular endothelial growth factor (VEGF) and its receptors (VEGFR). In 2004, the first agent targeting angiogenesis, bevacizumab (BV), was approved as an adjunct to first-line cytotoxic treatment of metastatic CRC. The role of BV as part of adjuvant treatment and in combination with other targeted therapies is the subject of ongoing trials. However, BV is associated with an increase in the risk of arterial thromboembolic events, hypertension and gastrointestinal perforations and its use must be cautious. Novel VEGFR TK inhibitors with different ranges of nanomolar potencies, selectivities, and pharmacokinetic properties are entering phase Ⅲ trials for the treatment of cancer. Conversely, one of these novel agents, vatalanib, has been shown not to confer survival benefit in first and second-line treatment of advanced CRC. The basis of these findings is being extensively evaluated. Ongoing and new well-designed trials will define the optimal clinical application of the actual antiangiogenic agents, and, on the other hand, intensive efforts in basic research will identify new agents with different antiangiogenic approaches for the treatment of CRC. In this review we discuss and highlight current and future approaches in angiogenic targeting for CRC. | Aleix Prat Esther Casado Javier Cortés | 2007 | World Journal of Gastroenterology2007，13，44： | 6 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Advances and applications of in- duced pluripotent stem cells 显示文摘 | Pietronave S Prat M | 2012 | Can J Physiol Pharmacol2012，90，： | 1 |
| 4 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 5 | Development of real-time PCR systems based on SYBR(R) Green I, Amplifluor (TM) and TaqMan (R) technologies for specific quantitative detection of the transgenie maize event GA21 显示文摘 | Hernandez M Esteve T Prat S | 2004 | J Cereal Sci2004，39，： | 1 |
| 6 | Development of real-time PCR systems based on SYBR~ Green I, Am- plifluorTM and TaqMan~ technologies for specific quantitative detection of the transgenic maize event GA21显示文摘 | Hern6ndez M Esteve T Prat S | 2004 | Journal of Cereal Science2004，39，1： | 1 |
| 7 | Prolonged persistence of Listeria monocytogenes after intragastric infection in corticosteroid - treated mice显示文摘 | PRATS N LOPEZ S DOMINGO M | | Vet Microbiol0，58，1： | 1 |
| 8 | Conserved MYC transcription factors play a key role in jasmonae signaling both in tomato and Arabidopsis显示文摘 | BOTER M RUIZ-RIVERO O ABDEEN A PRAT S | 2004 | Genes2004，18，： | 1 |
| 9 | Evaluation of a Legionel-la urinary antigen enzyme immunoassay for rapid detection ofLegionella pneumophila in water samples显示文摘 | Blanco S Prat C Sa nchez MD | 2008 | Int J Hyg EnvironHealth2008，211，12： | 1 |
| 10 | Transforming shape in design: observations from studies of sketching 显示文摘 | PRATS M LIM S JOWERS I | 2009 | Design Studies2009，30，5： | 1 |
| 11 | Implication of the proprotein convertase PCSK9/NARC-1 in the development of the nervous system 显示文摘 | Poirier S Prat A Marcinkiewicz E | 2006 | J Neurochem2006，98，3： | 1 |
| 12 | A cDNA clone highly expressed in ripe banana fruit shows homology to pectate lyases显示文摘 | Dominguez-Puigianer E Llop I Vendrell M Prat S | 1997 | Plant Physiology1997，114，： | 1 |
| 13 | Feedback control and diurnal regulation of gibberellin 20-oxidase transcript levels in potato显示文摘 | Carrera E Jackson S D Prat S | 1999 | Plant Physiol1999，119，2： | 1 |
| 14 | Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long - lived species: the pigeon and human case显示文摘 | PAMPLONA R PRAT J CADENAS S | 1996 | Mech Ageing Dev1996，86，： | 1 |
| 15 | GenoType MTBDRplus Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Strains and Clinical Samples 显示文摘 | A Lacoma N Garcia-Sierra C Prat J Ruiz-Manzano L Haba S Ros6s J Maldonado J Dominguez | 2008 | J Clin Microbiol2008，46，11： | 1 |
| 16 | A renewable tissue resource of phenotypically stable,biologically and ethnically diverse,patient-derived human breast cancer xenograft models显示文摘 | Zhang X Claerhout S Prat A | | 0，，15： | 1 |
| 17 | Naturally occurring allele diversity allows potato cultivation in northern latitudes 显示文摘 | Kloosterman B Abelenda J A Gomez Mdel M Oortwijn M de Boer J M Kowitwanich K Horvath B M van Eck H J Smaczniak C Prat S Visser R G Baehem C W | 2013 | Nature2013，495，7440： | 1 |
| 18 | Spinal tuberculosis: early surgical treatment combined with midcal treatment 显示文摘 | Fuster S Sala P Prat S | 2001 | Med Clin (Bare)2001，117，12： | 1 |
| 19 | Cis regulatory elements directing tuber-specific and sucrose-inducible expression of a chimeric class I patatin promoter/GUS- gene fusion显示文摘 | Liu X J Prat S Willmitzer L | 1990 | Mol Gen Genet1990，223，3： | 1 |
| 20 | Regulation of Transcript Levels of a Potato Gibberellin 20-Oxidase Gene by Light and Phytochrome B显示文摘 | Jackson S D James P E Prat S | | 0，，： | 1 |
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