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| 1 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 2 | Long Term Salinity Stress Reveals Variety Specific Differences in Root Oxidative Stress Response显示文摘Salinity stress induces oxidative stress caused by reactive oxygen species(ROS):superoxide radicals,hydrogen peroxide(H2O2) and hydroxyl radicals.Activities of both enzymatic and non-enzymatic components of the antioxidant system and related growth parameters were studied in the roots of the salt tolerant rice variety FL478 and the sensitive variety IR29 in response to long term stress(12 d) induced by 50 mmol/L NaCl.The comparative study showed that FL478 maintained higher relative growth rate and lower Na+/K+ in the roots than IR29 due to a higher membrane stability index that effectively exclude Na+.Lower TBARS(thiobarbituric acid reactive substance) content in FL478 roots indicated that its membrane was relatively unaffected by ROS despite high H2O2 content recorded under the salinity stress.Relatively higher superoxide dismutase activity along with a parallel increase in transcript level of superoxide dismutase(Os07g46990) in FL478 indicated that this protein might make a vital contribution to salt stress tolerance.Although the content of ascorbic acid remained unchanged in FL478,the activity of ascorbic peroxidases(APOXs) was reduced comparably in the both varieties.Transcriptomic data showed that a larger number of peroxidase genes were upregulated in FL478 compared to IR29 and several of which might provide engineering targets to improve rice salt tolerance. | Prasad SENADHEERA Shamala TIRIMANNE Frans J M MAATHUIS | 2012 | Rice science2012，19，1： | 3 |
| 3 | Wound complications following operative fixation of calcaneal fractures显示文摘 | M Al-Mudhaffar C.V.R Prasad A Mofidi | 2000 | Injury2000，，6： | 2 |
| 4 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery显示文摘 | Jaya Mishra Catherine Dent Ridwan Tarabishi Mark M Mitsnefes Qing Ma Caitlin Kelly Stacey M Ruff Kamyar Zahedi Mingyuan Shao Judy Bean Kiyoshi Mori Jonathan Barasch Prasad Devarajan | 2005 | The Lancet . 2005 (9466)2005，，： | 2 |
| 5 | Inhibition of maize leaf chlorophylls,carotenoids and gas exchange functions by cadmium显示文摘 | Prasad M N V | 1995 | Photosythetica1995，31，： | 2 |
| 6 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 7 | The role of statistics in signal processing a brief review and some emerging trends显示文摘 | Prasad S Chakraborty M Parthasarathy H | 1995 | Indian J Pure Appl Math1995，26，： | 2 |
| 8 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 9 | Simulation of Frontal Barrier Offset Impacts and Comparison of Intrusions and Decelerations 显示文摘 | SAHA N K CALSO S M PRASAD P | 1995 | SAE Transactions1995，104，1： | 1 |
| 10 | Gamma surgery for vestibular schwannoma显示文摘 | Steiner M Steiner L | 2000 | J Neurosurg2000，92，5： | 1 |
| 11 | Potential of siderophore-producing bacteria for improving heavy metal phytoextraction显示文摘 | Rajkumar M Ae N Prasad MNV | 2009 | Trends in Biotechnology2009，28，3： | 1 |
| 12 | Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality显示文摘 | PRASAD A SINGH M LERMAN A | 2006 | J Am Coll Cardio12006，48，9： | 1 |
| 13 | Identification of major quantitative trait loci qSBR11-1 for sheath blight resistance in rice显示文摘 | Channamallikarjuna V Sonah H Prasad M | 2010 | Molecular Breeding2010，25，1： | 1 |
| 14 | Deformation and Fracture Behavior of Cast and Extruded 7075Al-SiCP Composites at Room and Elevated Temperature显示文摘 | Kulkarni M D Pobi P S Prasad R C | 1996 | Mater Trans JIM1996，37，： | 1 |
| 15 | Efficient and convenient polyethylene glyeol(PEG)-mediated synthesis of spiro-oxindoles显示文摘 | Meshram H M Kumar D A Prasad B R V | 2010 | Helvetica Chimica ACTA2010，93，4： | 1 |
| 16 | Synthesis of a re- usable oxotungsten-containing SBA-15 mesoporous catalyst for the organic solvent-free conversion of cyclohexene to a- dipic acid显示文摘 | Cheng C Y Lin K J Prasad M R | 2007 | Catal Commun2007，8，7： | 1 |
| 17 | What to do when war- farin therapy goes too far显示文摘 | Prasad S Wootten M R Kulinski N | 2009 | J Fam Pract2009，58，7： | 1 |
| 18 | Experimen- tal study of an air-cooled thermal rnanagement system for high capacity lithium-titanate batteries 显示文摘 | Giuliano M R Ajay Prasad K Advani S G | 2012 | Journal of Power Sources2012，216，： | 1 |
| 19 | Influence of solid acids as co-catalysts on glycerol hydrogenolysis to propy- lene glycol over Ru/C catalysts 显示文摘 | BalaraJu M Rekha V Prasad P S | 2009 | Applied Catalysis A: General2009，354，1： | 1 |
| 20 | The effects of exercise and two levels of dietary iron on iron status显示文摘 | Prasad M C.Pratt | | 0，，11： | 1 |
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