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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Formanilide and Carbanilide from aniline and carbon dioxide显示文摘 | Pradip M David J H Erin P M | 2003 | Tetrahedron Lett2003，44，： | 1 |
| 3 | Anion water in gypsum(CaSO4·2H2O)and hemihydrate(CaSO4/2H2O)显示文摘 | Pradip K M T anuj K M | 2002 | Cement Concrete Research2002，32，2： | 1 |
| 4 | Role of powder size, packing, solid loading and dispersion in colloidal processing of ceramics显示文摘 | M Subbanna P.C Kapur Pradip | 2002 | Ceramics International2002，，4： | 1 |
| 5 | Anion water in gypsum (CaSO4· 2H20) and hemihydrate (CaSO4 · 1/2H2 O) 显示文摘 | Pradip K M Tanuj K M | 2002 | Cem Coner Res2002，32，2： | 1 |
| 6 | Structural studiesof a heteropolysaccharide (PS-I) isolated from hot waterextract of fruits of Psidium guajava (Guava)显示文摘 | Soumitra M Ransankar S Pradip P | 2009 | CarbohydrateResearch2009，334，： | 1 |
| 7 | Preparation of calcium sulphoaluminate cement using fertiliser plant wastes 显示文摘 | Singh M P C Kapur Pradip | 2008 | Journal of Hazardous Materials2008，157，1： | 1 |
| 8 | Zeta Potentials in the Flotation of Oxide and Silicate Minerals显示文摘 | Fuerstenau D W Pradip M J | 2005 | Advances in Colloid and Interface Science2005，，： | 1 |
| 9 | Incidence of Oronasal Fistula Formation After Nasoalveolar Mold- ing and Primary Cleft Repair显示文摘 | Dec Wojciech M D Shetye Pradip R Grayson Barry H | 2013 | Journal of Craniofacial surgery2013，24，1： | 1 |
| 10 | Challenges in processor modeling and validation显示文摘 | Pradip Bose Tomas M Conte Todd M Austin | 1999 | Micro1999，，5： | 1 |
| 11 | Live virtual machinemigration techniques in cloud computing: A survey 显示文摘 | Pradip D Miren K Bhavsar M | 2014 | International Journal of Computer Applications2014，86，16： | 1 |
| 12 | Characterization of a continu ous C02 laser-welded Fe-Cu dissimilar couple显示文摘 | Grandham P Sambandam M Pradip D | 2005 | Metal- lurgical and Materials Translations A2005，36，8： | 1 |
| 13 | Molecular modeling of interactions of alkyl hydroxamates with calcium minerals显示文摘 | PRADIP RAI B RAO T K SHAILAJA K VETRIVEL R MIELCZARSKI J CASES J M | 2002 | Journal of Colloid and Interface Science2002，256，1： | 1 |
| 14 | Molecular modelling of interactions of diphosphonic acid based surfactants with calcium minerals 显示文摘 | PRADIP PAl B RAO T K KR/SHNAMURTHY S VETRIVEL R MIELCZARSKI J CASES J M | 2002 | Langmuir2002，18，3： | 1 |
| 15 | A study on en- docrine changes in patients in intensive care unit显示文摘 | Pranab KS Asutosh G Pradip M | 2008 | J In- dian Med Assoc2008，106，6： | 1 |
| 16 | Halogen-free room-tem- perature brnsted acidic ionic liquid HSO4 as a reeyclable green'dual reagent' catalysis for the synthesis of triarylmethanes (TRAMs) 显示文摘 | Chhanda M Amp D Pradip K T | 2012 | Synth Commun2012，42，6： | 1 |
| 17 | Molecular modeling of interactions of alkyl hydroxamates with calcium minerals显示文摘 | PRADIP M RAI B RAO T K | 2002 | Journal of Colloid and Interface Science2002，256，： | 1 |
| 18 | Design and dev-elopment of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability显示文摘 | PRADIP K G RITA J M MANISH L U | 2006 | AAPS Pharm Sci Tech2006，7，3： | 1 |
| 19 | Stimulating Knowledge Sharing: Strengthening Your Organization's Internal Knowledge Market显示文摘 | Eric M Pradip P Tan S | 2003 | Organizational Dynamics2003，，32： | 1 |
| 20 | Preparation of calcium sulphoaluminute cement using fcrtiliscr plant wastes 显示文摘 | SINGH M KAPUR P C PRADIP | 2008 | J Hazard Mater2008，157，： | 1 |
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