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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | Relationship between ratio of pristane to phytane, crude oil composition and geological environment in Australia显示文摘 | POWELL T G MCKIRDY D M | 1973 | Nature1973，243，124： | 1 |
| 4 | An efficient method for finding the niinimum of a function of several variables without calculating derivatives显示文摘 | Powell M J D | 1964 | Comput J1964，7，： | 1 |
| 5 | Introduction of gaseous hydrides into an inductively coupled plasma mass spectrometer显示文摘 | POWELL M J BOOMER D W MCVICARS R J | 1986 | Analytical Chemistry1986，58，13： | 1 |
| 6 | Relationship between ratio of pristine to phytane, crude oil composition and geological environments inAustralia显示文摘 | Powell T Mckirdy D M | 1973 | Nature1973，243，： | 1 |
| 7 | Proteinase inhibition of the detection of Listeria monocytogenes in milk using the polymerase chain reaction 显示文摘 | Powell H A Gooding C M Garrett S D | 1994 | Lett Appl Microbiol1994，18，： | 1 |
| 8 | Reduced drag coefficient for high wind speeds in tropical cyclones显示文摘 | POWELL M D VICKERY P J REINHOLD T A | 2003 | Nature2003，422，： | 1 |
| 9 | A fast algorithm for nonlinearly constrained optimization calculations 显示文摘 | Powell M J D | 1978 | Numerical Analysis1978，，630： | 1 |
| 10 | Hydraulic conductivity of a recent estuarine silty clay at Bothkennar显示文摘 | LEROUEIL S LERAT P HIGHT D W POWELL J J M | 1992 | Geotechnique1992，42，2： | 1 |
| 11 | Reduced drag coefficient for high wind speeds in tropical cyclones 显示文摘 | POWELL M D VICKERY P J REINHOLD T A | 2005 | Nature2005，422，6929： | 1 |
| 12 | Pilot fatigue in short-haul operations : effects of number of sectors, duty length, and time of day显示文摘 | Powell D M C Spencer M B Holland D | 2007 | Aviation Space and Environmental Medicine2007，78，7： | 1 |
| 13 | LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporterl (SGLT1)- mediated absorption of intestinal glucose 显示文摘 | Powell D R Smith M Greer J | 2013 | J Pharmacol Exp Ther2013，345，2： | 1 |
| 14 | Fast evaluation ofpolyharmonic splines in three dimensions显示文摘 | Beatson R K Powell M J D Tan A M | 2006 | IMA Jour-nal of Numerical Analysis2006，27，3： | 1 |
| 15 | An efficient method for finding the minimum of a function of several variables without calculation derivatives显示文摘 | POWELL M J D | 1964 | Computer Journal1964，7，2： | 1 |
| 16 | A comparisonof commercial enzymes for the aqueous enzymatic extraction ofcom oil from com germ显示文摘 | Moreau R A Johnston D B Powell M J^ | 2004 | J Am Oil Chem Soc2004，81，11： | 1 |
| 17 | Proteinase inhibition of the detection of Listeria monocytogenes in milk using the polymerase chain reaction显示文摘 | Powell H A Gooding C M Garrett S D | 1994 | Letters in Applied Microbiology1994，18，1： | 1 |
| 18 | Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent eytokine secretion显示文摘 | Powell N D Bailey M T Mays J W | 2009 | Brain Behav Immun2009，23，2： | 1 |
| 19 | Effect of LX4211 on glucose homeostasis and body composition in preclinical models 显示文摘 | Powell D R DaCosta C M Smith M | 2014 | J Pharmacol Exp Ther2014，350，2： | 1 |
| 20 | Falls efficacy as a measure of fear of falling显示文摘 | Tinetti M Richman D Powel L | 1990 | J Georntol1990，45，： | 1 |
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