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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Ultrafast and memory- ef{cient alignment of short DNA sequences to the human ge- nome 显示文摘 | Langmead B Trapnell C Pop M | 2009 | Genome Biology2009，，： | 1 |
| 3 | Human caspases:activation,specificity and regulation显示文摘 | Pop C Salvesen G S | | 0，，33： | 1 |
| 4 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome 显示文摘 | Langmead B Trapnell C Pop M | 2009 | Genome Biology2009，10，3： | 1 |
| 5 | Limitations of Sum-of-sinusoids Fading Channel 8imulators显示文摘 | Pop M F Beaulie U Norman C | 2001 | IEEE Trans Commun2001，49，04： | 1 |
| 6 | Global DNA dem-ethylation during mouse erythropoiesis in vivo 显示文摘 | Shearstone JR Pop R Bock C | 2011 | Sci-ence2011，334，： | 1 |
| 7 | Free Convection in a Square Porous Cavity Using a Thermal Nonequilibrium Model显示文摘 | Baytas A C Pop I | 2002 | Int J Thermal Sciences2002，41，9： | 1 |
| 8 | Inducible dimeriza- tion and inducible cleavage reveal a requirement for both processes in caspase-8 activation显示文摘 | Oberst A Pop C Tremblay AG | 2010 | J Biol Chem2010，285，16： | 1 |
| 9 | Limitations of sum-of-sinusoids fading channel simulators显示文摘 | Pop M F Beaulieu N C | 2001 | IEEE Trans- actions on Communication2001，49，4： | 1 |
| 10 | Single cell analysis shows decreasing FoxP3 and TGF { beta } 1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes显示文摘 | Wong C P Culton D A | 2005 | J Exp Med2005，201，8： | 1 |
| 11 | Assessing the benefits of us- ing mate-pairs to resolve repeats in de novo short-read pro- karyotic assemblies显示文摘 | Wetzel J Kingsford C Pop M | 2011 | BMC Bioinf2011，12，1： | 1 |
| 12 | Physical activities for overweight and obese children-an inclusive approach显示文摘 | POP C | 2014 | Soc Behav Sci2014，163，： | 1 |
| 13 | A constitutively active and uninhibitable caspase-3 zymogen effieiently induces apoptosis 显示文摘 | Walters J Pop C Scott FL et d | 2009 | Biochem J2009，424，3： | 1 |
| 14 | A comparison of two- and four-electrode techniques to characterize blood impedance for the frequency range of 100 Hz to 100 MHz 显示文摘 | Chang Z Pop G A M Meijer G C M | 2008 | IEEE T Biomed Eng2008，55，3： | 1 |
| 15 | Free convection in a square porous cavity using a thermal non equilibrium model 显示文摘 | BAYTAS A C POP I | 2002 | Int J Therm Sci2002，41，9： | 1 |
| 16 | Conjugate natural convection in a square porous cavity显示文摘 | BAYTAS A C LIAQAT A POP I | 2001 | Heat and Mass transfer2001，，37： | 1 |
| 17 | Limitations of sum-of-sinusoids fading channel simulators 显示文摘 | POP M F BEAULIEU N C | 2001 | IEEE Trans Commun2001，149，4： | 1 |
| 18 | Free convection in a square porous cavity using a thermal non-equilibrium model 显示文摘 | BAYTAS A C POP I | 2002 | Int J Thermal Sci2002，41，9： | 1 |
| 19 | Ultrafast and memory- efficient alignment of short DNA sequences to the human genome 显示文摘 | Langmead B Trapnell C Pop M | 2009 | Genome Biol2009，10，： | 1 |
| 20 | Ul-trafast and memory-efficient alignment of short DNA sequences to the human genome显示文摘 | Langmead B Trapnell C Pop M Salzberg S.L | | 0，，： | 1 |
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