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| 1 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 2 | Recent studies on mechanical properties of recycled aggregate concrete in China-A review显示文摘Numerous experimental and theoretical studies on recycled aggregate concrete have been carried out in China in the past 10 years.This paper provides a comprehensive review of the related findings of research on the mechanical properties of RAC in China.The influences of the RCA on the strength and deformation characteristics of concrete,the statistical characteristics for the strength of RAC,fracture energy,stress-strain relationships under uniaxial compression,uniaxial tension as well as pure shear,and the residual strength of RAC after exposure to high temperatures,the bond between RAC and different kinds of steel rebar were also reviewed.Furthermore,some recent studies on the numerical simulation of the failure mechanism for RAC at the meso-structure level were discussed. | XIAO JianZhuang LI WenGui POON ChiSun | 2012 | Science China(Technological Sciences)2012，55，6： | 31 |
| 3 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 4 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 5 | Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation显示文摘AIM: To evaluate the outcome of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) <5 cm in diameter eligible for radiofrequency ablation (RFA).METHODS: The treatment-related mortality, morbidity,long-term survival, and prognostic factors of HCC patients who had TACE and fulfilled the present inclusion criteria for RFA were evaluated.RESULTS: Of the 748 patients treated with TACE between January 1990 and December 2002, 114 patients were also eligible for RFA. The treatment-related mortality and morbidity were 1% and 19%, respectively. Survival at 1, 3, and 5 years was 80%, 43%, and 23%, respectively. Older age and a high albumin level were associated with a better survival, whereas a high α-fetoprotein level (AFP) and the size of the largest tumor >3 cm in diameter were adverse prognostic factors in multivariate analysis.CONCLUSION: The morbidity, mortality, and survival data after TACE for small HCCs eligible for RFA are comparable to those reported after RFA in the literature. Our data suggest the need for a randomized comparison of the two treatment modalities for small HCCs. | Mike SL Liem Ronnie TP Poon Chung Mau Lo Wai Kuen Tso Sheung Tat Fan | 2005 | World Journal of Gastroenterology2005，11，29： | 15 |
| 6 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 7 | Compressive Strength, Pore Size Distribution and Chloride-ion Penetration of Recycled Aggregate Concrete Incorporating Class-F Fly Ash显示文摘The effects of fly ash on the compressive strength, pore size distribution and chloride-ion penetration of recycled aggregate concrete were investigated. Two series of concrete mixtures were prepared. The concrete mixtures in series I had a water-to-binder ratio and a cement content of 0.55 and 410 kg/m^3, respectively. The concrete mixtures in series II had a water-to-binder ratio and a cement content of 0.45 and 400 kg/m^3 respectively. Recycled aggregate was used as 20%, 50%, and 100% replacements of natural coarse aggregate in the concrete mixtures in both series. In addition, fly ash was used as 0%, 25% and 35% by weight replacements of cement. The results show that the compressive strengths of the concrete decreased as the recycled aggregate and the fly ash contents increased. The total porosity and average porosity diameter of the concrete increased as the recycled aggregate content increased. Furthermore, an increase in the recycled aggregate content decreased the resistance to chloride ion penetration. Nevertheless, the replacement of cement by 25% fly ash improved the resistance to chloride ion penetration and pore diameters and reduced the total porosity of the recycled aggregate concrete. | 寇世聪 C S Poon | 2006 | Journal of Wuhan University of Technology(Materials Science)2006，21，4： | 13 |
| 8 | Pharmacokinetic Studies of Factor VIII in Chinese Boys with Severe Hemophilia A: A Single-Center Study显示文摘 | Zhen-Ping Chen Pei-jing Li Gang Li Ling Tang Ying-Zi Zhen Xin-Yi Wu Xiao-Ling Cheng Koon Hung Luke Victor S Blanchette Man-Chiu Poon Qiu-Lan Ding Run-Hui Wu | 2018 | Chinese Medical Journal2018，，15： | 11 |
| 9 | A data-driven method for syndrome type identification and classification in traditional Chinese medicine显示文摘The efficacy of traditional Chinese medicine(TCM) treatments for Western medicine(WM) diseases relies heavily on the proper classification of patients into TCM syndrome types.The authors developed a data-driven method for solving the classification problem,where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data.The new method is a generalization of latent class analysis(LCA),which has been widely applied in WM research to solve a similar problem,i.e.,to identify subtypes of a patient population in the absence of a gold standard.A well-known weakness of LCA is that it makes an unrealistically strong independence assumption.The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA.This new method consists of six steps:data collection,symptom co-occurrence pattern discovery,statistical pattern interpretation,syndrome identification,syndrome type identification and syndrome type classification.A software package called Lantern has been developed to support the application of the method.The method was illustrated using a data set on vascular mild cognitive impairment. | Nevin Lianwen Zhang Chen Fu Teng Fei Liu Bao-xin Chen Kin Man Poon Pei Xian Chen Yun-ling Zhang | 2017 | Journal of Integrative Medicine2017，15，2： | 11 |
| 10 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma显示文摘 | Masao Omata Laurentius A. Lesmana Ryosuke Tateishi Pei-Jer Chen Shi-Ming Lin Haruhiko Yoshida Masatoshi Kudo Jeong Min Lee Byung Ihn Choi Ronnie T. P. Poon Shuichiro Shiina Ann Lii Cheng Ji-Dong Jia Shuntaro Obi Kwang Hyub Han Wasim Jafri Pierce Chow Seng | 2010 | Hepatology International2010，，2： | 11 |
| 11 | Prevention of diabetic microangiopathy by prophylactic transplant of mobilized peripheral blood mononuclear cells显示文摘目的:调查 mobilizedperipheral 血 mononuclear 房间( M-PBMNC )的预防本地交货是否能在 diabeticnude mice.Methods 阻止外部 microangiopathy :糖尿病的裸体老鼠与 intraperitoneal 注射 ofstreptozotocin.With 被导致糖尿病的时间功课,我们检测了毛状并且由 immuno-histopathy.In situ apoptosis 的小动脉密度 ofmice 内转肌肌肉被使用标记的 调停TdT 的 dUTPnick 结束( TUNEL )检测 methods.M-PBMNC 被标记并且 | Bin ZHOU Xiao-cang CAO Zhi-hong FANG Cui-lin ZHENG Zhi-bo HAN He REN Man-chiu POON Zhong-chao HAN | 2007 | Acta Pharmacologica Sinica2007，28，1： | 10 |
| 12 | 中国人地关系评价的理论模型与实证(英文)显示文摘China’s coupled human-environment system(CHES) is assessed here via a systems schema that emphasizes the complex interactions of components and their attributes. In addition to the human and environment components, we identified two other components to evaluate the relationship. The four components are human activity intensity, resource carrying capacity, ecological constraints and system’s openness. Based on their interactions, we derived a cognitive schema for classifying the level of strain or stress of an area. The analysis draws on 11 indicators and 29 sub-indicators including remote sensing data and statistical data that are used to estimate the four components. The findings indicate that human activities are highly intense in a few geographical areas, particularly large urban systems and trade and investment zones on the eastern coastal areas. Nonetheless, these areas are also well-endowed in water resources and fertile soils although urban systems are increasingly stressed from negative pollution externalities. They are also open systems which allow them to bear a higher level of pressure and adjust accordingly. Desertification and soil erosion point to relatively fragile biophysical systems in the west and southwest, but human activities are still relatively less intense compared to their coastal counterparts. As a whole, only 14% of areas may be said to be relatively or highly strained. This however belies another one-third of areas that are currently unstable, and likely to become strained and thereby vulnerable in the near future. | 杨宇 李小云 董雯 POON PH Jessie 洪辉 何则 刘毅 | 2019 | Journal of Geographical Sciences2019，29，8： | 9 |
| 13 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 14 | Little girl who conquered the 'ALPPS''显示文摘An insufficient future liver remnant(FLR)is associated with post-hepatectomy liver failure.Associating liver partition and portal vein ligation for stage hepatectomy(ALPPS)has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR.We hereby report our experience of this novel approach for a 6-year-old patient with hepatoblastoma.Computed tomography showed a hepatoblastoma measuring12.5 cm×9.9 cm×11.7 cm in the right liver(Couinaud segmentⅣ,ⅤandⅧ).Volumetric assessment of the FLR i.e.,left lateral section was 112.6 mL i.e.,21.2%of the estimated total liver volume.In view of the small-for-size FLR,ALPPS was contemplated.An anterior approach was adopted for the in-situ parenchymal split without mobilisation of the right liver.FLR volumetry on the seventh postoperative day was 160.7 mL,which represented a 46.1%gain in volume,and a FLR/ESLV ratio of 30.2%.A right trisectionectomy was performed on the eighth postoperative day.Postoperative recovery was uneventful.Patient was discharged on day 16 after the first operation.To our knowledge,this was the first report that showed the applicability of ALPPS to a paediatric patient. | Albert Chan Patrick HY Chung Ronnie TP Poon | 2014 | World Journal of Gastroenterology2014，20，29： | 8 |
| 15 | Synchronous resections of primary colorectal tumor and liver metastasis by laparoscopic approach显示文摘Liver metastasis of colorectal cancer is common. Resection of solitary tumors of primary and metastatic colorectal cancer can have a favorable outcome. Open resection of primary colorectal tumor and liver metastasis in one operation or in separate operations is currently common practice. Reports have shown that synchronous resections do not jeopardize short or long-term surgical outcomes and that this is a safe and effective approach in open surgery. The development of laparoscopic colorectal surgery and laparoscopic hepatectomy has made a minimally invasive surgical approach to treating colorectal cancer with liver metastasis feasible. Synchronous resections of primary colorectal tumor and liver metastasis by laparoscopy have recently been reported. The efficacy and safety of laparoscopic colorectal resection and laparoscopic hepatectomy have been proven separately but synchronous resections by laparoscopy are in hot debate. As it has been shown that open resection of primary colorectal tumor and liver metastasis in one operation results in an equally good short-term outcome when compared with that done in separate operations, laparoscopic resection of the same in one single operation seems to be a good option. Recent evidencehas shown that this new approach is a safe alternative with a shorter hospital stay. Large scale randomized controlled trials are needed to demonstrate the effectiveness of this minimally invasive approach. | Tan To Cheung Ronnie Tung Ping Poon | 2013 | World Journal of Hepatology2013，5，6： | 8 |
| 16 | Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly- developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON , one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73.CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. | Tan To Cheung See Ching Chan Kenneth SH Chok Albert CY Chan Wan Ching Yu Ronnie TP Poon Chung Mau Lo Sheung Tat Fan | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 8 |
| 17 | 血友病在加拿大的医疗状况显示文摘加拿大全国有24个血友病诊疗所,其中大多数负责治疗A、B型血友病,血管性血友病(vWD)及其它先天性出血性疾病。1997年5月31日加拿大血友病注册登记表明,在2066例血友病患者中,血友病A为1660例(80.3%),血友病B为406例(19.7%... | Poon,M 赵滨江 | 1998 | 中华血液学杂志1998，19，9： | 7 |
| 18 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 19 | Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report显示文摘Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT. | Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 20 | Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma显示文摘 | Chung-Mau Lo Henry Ngan Wai-Kuen Tso Chi-Leung Liu Chi-Ming Lam Ronnie Tung-Ping Poon Sheung-Tat Fan John Wong | 2002 | Hepatology2002，，5： | 7 |
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