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| 1 | Role of Nrf2 in chronic liver disease显示文摘Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases. | Wei Tang Yong-Fang Jiang Murugavel Ponnusamy Mamadou Diallo | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 2 | Throughput Analysis of the IEEE 802.11 Distributed Coordination Function Considering Erroneous Channel and Capture Effects显示文摘This paper presents a performance study of the distributed coordination function (DCF) of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic access method.The aggregate throughput of a practical wireless local area network (WLAN) strongly depends on the channel conditions.In a real radio environment,the received signal power at the access point from a station is subjected to deterministic path loss,shadowing,and fast multipath fading.The binary exponential backoff (BEB) mechanism of IEEE 802.11 DCF severely suffers from more channel idle time under high bit error rate (BER).To alleviate the low performance of IEEE 802.11 DCF,a new mechanism is introduced,which greatly outperforms the existing methods under a high BER.A multidimensional Markov chain model is used to characterize the behavior of DCF in order to account both non-ideal channel conditions and capture effects. | Ponnusamy Kumar A.Krishnan | 2011 | International Journal of Automation and computing2011，8，2： | 6 |
| 3 | In vitro biofilm formation by uropathogenic Escherichia coli and their antimicrobial susceptibility pattern显示文摘Objective:To detect in vitro biofilm formation of uropathogenic Escherichia coli(E.coli)(UPEC) strains isolated from urine specimens and also to determine their antimicrobial susceptibility pattern using 13 commonly used antibiotics.Methods:The present study comprised of 166 urine specimens collected from tertiary care hospitals in and around Coimbatore.South India. All the specimens were subjected to gram staining,bacterial culture and the E.coli strains were screened for biofilm formation using Tube Method(TM),Congo Red Agar(CRA) and Tissue Culture Plate method(TCP) respectively.Subsequently,the antimicrobial susceptibility test was performed by Kirby Bauer-disk diffusion method for the biofilm and non-biofilm producing E. coli strains.Results:Of the 100(60.2%) E.coli strains,72 strains displayed a biofilm positive phenotype under the optimized conditions in the Tube Method and the strains were classified as highly positive(17,23.6%),moderate positive(19.26.3%) and weakly positive(36.50.0%). similarly under the optimized conditions on Congo Red agar medium,biofilm positive phenotype strains were classified as highly positive(23,23%).moderate positive(37.37%) and weakly positive(40,40%).While in TCP method,the biofilm positive phenotype strains were also classified as highly positive(6.6%),moderate positive(80.80%) and weakly positive(14,14%),it didn’t not correlate well with the tube method for detecting biofilm formation in E.coli.The rates of antibiotic resistance of biofilm producing E.coli were found to be 100%for chloramphenicol and amoxyclav(amoxicillin and clavulanic acid),86%for gentamicin and cefotaxime.84%for ceftazidime,83%for cotrimoxazole and piperacillin/tazobactam,75%for tetracycline and 70% for amikacin,Conclusions:This study reveals the prevalence and antimicrobial susceptibility pattern of biofilm and non-biofilm producing uropathogenic E.coli strains. | Poovendran Ponnusamy Vidhya Natarajan Murugan Sevanan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，3： | 5 |
| 4 | The effect of leaves extracts of Clitoria ternatea Linn against the fish pathogens显示文摘Objective:To investigate the antimicrobial activity of Clitoria ternatea(C.ternatea) against the fish pathogens viz.,Pseudomonas aeruginosa(P.aeruginosa),Escherichia coli(E.coli),Klebsiella pneumonia(K.pneumonia),Bacillus subtilis(B.subtilis),Aeromonas formican(A.formicans)s, Aeromonas hydrophila(A.hydrophila) and Streptococcus agalactiae(S.agalactiae )isolated from diseased Tilapia(Oreochromis niloticus).Methods:The extracts of C.ternatea was tested against P.aeruginosa,E.coli,K.pneumonia,B.subtilis,A.formicans,A.hydrophila and S.agalactiae by the agar well diffusion method.Results:Different extracts of C.ternatea showed inhibitory effects against P.aeruginosa,E.coli,K.pneumonia,B.subtilis,A.formicans,A.hydrophila and S. agalactiae.Ethyl acetate extracts of C.ternatea showed maximum of zone of inhibition against A. formicans(18 mm),A.hydrophilia(19 mm),B.subtilis(19 mm) and P.aeruginosa(21 mm) next to that ethanol extract of C.ternatea showed A.formicans(18 mm) and E.coli(14 mm) followed by Acetone extract showed maximum zone of inhibition S.agalactiae(19 mm) and K.pneumonia(17 mm).Conclusions:The antimicrobial activities of all the four plant extracts are comparable and their potential as alternative in the treatment of infectious by these microorganisms was present in the fish.Susceptibility testing is conducted on isolates using drugs selected on the basis of their importance to human medicine and use in fish production. | Selvamaleeswaran Ponnusamy Wesely Ebenezer Gnanaraj Johnson Marimuthu Antonisamy Velusamy Selvakumar Jeyakumar Nelson | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 4 |
| 5 | Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro显示文摘 | Sudha Ponnusamy Remya Ravindran Smita Zinjarde Shobha Bhargava Ameeta Ravi Kumar | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 3 |
| 6 | Alphabet Strategy for diabetes care: A multi-professional, evidence-based, outcome-directed approach to management显示文摘With the rising global prevalence in diabetes, healthcare systems are facing a growing challenge to provide efficient and effective diabetes care management in the face of spiralling treatment costs. Diabetes is a major cause of premature mortality and associated with devastating complications especially if managed poorly. Although diabetes care is improving in England and Wales, recent audit data suggests care remains imperfect with wide geographical variations in quality. Diabetes care is expensive with a sizeable amount of available expenditure used for treating the complications of diabetes. A target driven, long-term, multifactorial intervention in patients with type 2 diabetes has been shown to reduce mortality and morbidity. The alphabet strategy is a novel approach to effective diabetes care provision, aiming to address patient education and empowerment, provide consistent comprehensive care delivered in a timely fashion, and allowing multidisciplinary team work. | James D Lee Ponnusamy Saravanan Vinod Patel | 2015 | World Journal of Diabetes2015，6，6： | 3 |
| 7 | Electrospinning of curcumin loaded chitosan/poly (lactic acid) nanofilm and evaluation of its medicinal characteristics显示文摘curcumin 装载了 chitosan/poly (乳的酸)(PLA ) nanofibers 用 electrospinning 被生产。BoxBehnken 试验性的设计被用于变量的优化(1, 0, + 1 编码水平) 相似 chitosan/PLA 力量(% w/v ) , curcumin 力量(% w/v ) 和应用电压(kV ) 到获得一致纤维直径。nanofibers 的形态学被 SEM 显示出。分子的相互作用和 curcumin 的各化学的化合物的存在装载了 chitosan/PLA 纤维被 FTIR 和 EDX 分析描绘。抗氧化剂,药版本并且在 vitro cytotoxicity,测试被执行评估将被用于创伤愈合的 nanofibers 的适用性。在愈合弯屈在切除和切口上学习的 vivo,创伤在给创伤区域的重要减小看是否的老鼠模型上创造了与相比未经治疗。更好愈合的效率能被归因于 curcumin 和 chitosan 的存在。 | Bhaarathi DHURAI Nachimuthu SARASWATHY Ramasamy MAHESWARAN Ponnusamy SETHUPATHI Palanisamy VANITHA Sukumar VIGNESHWARAN~, and Venugopal RAMESHBABU | 2013 | Frontiers of Materials Science2013，7，4： | 2 |
| 8 | Intrusion Detection Systems in Internet of Things and Mobile Ad-Hoc Networks显示文摘Internet of Things(IoT)devices work mainly in wireless mediums;requiring different Intrusion Detection System(IDS)kind of solutions to leverage 802.11 header information for intrusion detection.Wireless-specific traffic features with high information gain are primarily found in data link layers rather than application layers in wired networks.This survey investigates some of the complexities and challenges in deploying wireless IDS in terms of data collection methods,IDS techniques,IDS placement strategies,and traffic data analysis techniques.This paper’s main finding highlights the lack of available network traces for training modern machine-learning models against IoT specific intrusions.Specifically,the Knowledge Discovery in Databases(KDD)Cup dataset is reviewed to highlight the design challenges of wireless intrusion detection based on current data attributes and proposed several guidelines to future-proof following traffic capture methods in the wireless network(WN).The paper starts with a review of various intrusion detection techniques,data collection methods and placement methods.The main goal of this paper is to study the design challenges of deploying intrusion detection system in a wireless environment.Intrusion detection system deployment in a wireless environment is not as straightforward as in the wired network environment due to the architectural complexities.So this paper reviews the traditional wired intrusion detection deployment methods and discusses how these techniques could be adopted into the wireless environment and also highlights the design challenges in the wireless environment.The main wireless environments to look into would be Wireless Sensor Networks(WSN),Mobile Ad Hoc Networks(MANET)and IoT as this are the future trends and a lot of attacks have been targeted into these networks.So it is very crucial to design an IDS specifically to target on the wireless networks. | Vasaki Ponnusamy Mamoona Humayun NZJhanjhi Aun Yichiet Maram Fahhad Almufareh | 2022 | Computer Systems Science & Engineering2022，40，3： | 2 |
| 9 | Separation of model mixtures of epsilon-globin positive fetal nucleated red blood cells and anucleate erythrocytes using a microfluidic device显示文摘 | Daniel L Ponnusamy S Aniza M | 2010 | Journal of Chromatography A2010，64，71： | 1 |
| 10 | Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis 显示文摘 | Ponnusamy MP Venkatraman G Singh AP | 2007 | Cancer Lett2007，251，2： | 1 |
| 11 | Anti-biofouling property of vanillin on Aeromonas hydrophila initial biofilm on various membrane surfaces显示文摘 | K. Ponnusamy S. Kappachery M. Thekeettle J. H. Song J. H. Kweon | 2013 | World Journal of Microbiology and Biotechnology2013，，9： | 1 |
| 12 | Rapid shortening of telomere length in response to eeramide in- voloves the inhibition of telomere binding activity of nu clear glyceraldehyde-3- phosphate dehydrogenase显示文摘 | Sundararaj K P Wood R E Ponnusamy S | 2004 | Journal of Biological Chemistry2004，9，7： | 1 |
| 13 | Indirubin potentiates ciprofloxacin activity in the Nora efflux pump of Staphylococcusaureus显示文摘 | PONNUSAMY K RAMASAMY M SAVARIMUTHU I | 2010 | Scand J Infect Dis2010，42，67： | 1 |
| 14 | Current practices of high and low flow oxygen therapy and humidification in UK neonatal units显示文摘 | Nath P Ponnusamy V Willis K | 2010 | Pediatr Int2010，52，6： | 1 |
| 15 | Properties of some class of planar harmonic and planar biharmonic mappings显示文摘 | CHEN S H PONNUSAMY S WANG X T | 2011 | Complex Analysis and Operator Thorey Oper Theory2011，5，3： | 1 |
| 16 | Management of acuterenal failure in the elderly patient: a clinician's guide 显示文摘 | Cheung CM Ponnusamy A Anderton JG | 2008 | DrugsAging2008，25，45： | 1 |
| 17 | A novel graphene nanosheets coated stainless steel fiber for microwave assisted headspace solid phase microextraction of organochlorine pesticides in aqueous samples followed by gas chromatography with electron capture detection显示文摘 | Ponnusamy V K Jen J F | 2011 | J Chromatogr A2011，1218，39： | 1 |
| 18 | Immunopathogenesis of ovarian cancer 显示文摘 | TORRES M P PONNUSAMY M P LAKSHMANAN I | 2009 | Minerva Med2009，100，： | 1 |
| 19 | Designing, structural, redox and biological investigation of copper ( II), nickel ( II ), cobalt ( II ), Zinc ( II ) and vanadium ( IV ) complexes derived from 1-phenyl-2,3-dimethyl-4- imino- ( 3-oxo-N-phenylbutamide ) -pyrozol-5- ( a-imino ) - indole-3-propionic acid 显示文摘 | Thavuduraj K Antonysamy K Ponnusamy T | 2013 | Journal of Pharmacy Re- search2013，1，2： | 1 |
| 20 | Equilibrium and thermodynamic studies on the adsorption of an organophosphorous pesticide onto 'waste' jute fiber carbon显示文摘 | Sadasivam S Krishna S K Ponnusamy K | 2010 | J Chem Eng Data2010，55，12： | 1 |
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