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| 1 | Small bowel tumors detected and missed during capsule endoscopy: Single center experience显示文摘AIM:To characterize small bowel(SB)tumors detected by capsule endoscopy(CE),and identify missed tumors.METHODS:The study included 145 consecutive patients in whom 150 CEs were performed.Following CE,the medical records of the study population were reviewed.Results of double-or single-balloon enteroscopy performed after CE and the results of surgery in all patients operated on were retrieved.The patients were contacted through telephone interviews or postal mail.In addition,the national cancer registry and the polish clinical gastrointestinal stromal tumor(GIST)Registry were searched to identify missed neoplasms.RESULTS:Indications for CE included overt and occult obscure gastrointestinal bleeding(n=81,53.7%),anemia(n=19,12.7%),malabsorption(n=18,12%),abnormal CB follow through(n=9,6%),abdominal pain(n=7,5%),celiac disease(n=5,3%),neuroendocrine tumor(n=3,2%),Crohn’s disease(n=2,<2%),Peutz-Jeghers syndrome(n=2,<2%),other polyposes(n=2,<2%),and diarrhea(n=2,<2%).The capsule reached the colon in 115(76.6%)examinations.In 150 investigations,CE identified 15SB tumors(10%),14 of which were operated on or treated endoscopically.Malignancies included metastatic melanoma(n=1),adenocarcinoma(n=2),and GIST(n=3).Benign neoplasms included dysplastic Peutz-Jeghers polyps(n=4).Non-neoplastic masses included venous malformation(n=1),inflammatory tumors(n=2),and a mass of unknown histology(n=1).During the follow-up period,three additional SB tumors were found(2 GISTs and one mesenteric tumor of undefined nature).The National Cancer Registry and Polish Clinical GIST Registry revealed no additional SB neoplasms in the post-examination period(follow-up:range 4.2-102.5 mo,median 39 mo).The sensitivity of CE for tumor detection was 83.3%,and the negative predictive value was 97.6%.The specificity and positive predictive value were both 100%.CONCLUSION:Neoplasms may be missed by CE,especially in the proximal SB.In overt obscure gastrointestinal bleeding,complementary endoscopic and/or radiologic diagnostic tests are indicated. | Edyta S Zagorowicz Anna M Pietrzak Ewa Wronska Jacek Pachlewski Piotr Rutkowski Ewa Kraszewska Jaroslaw Regula | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 2 | Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation显示文摘AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. | Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec | 2013 | World Journal of Gastroenterology2013，19，27： | 8 |
| 3 | Prey reduce risk-taking and abundance in the proximity of predators显示文摘 | Anders. R MФLLER Zbigniew KWIECINSKI Piotr TRYJANOWSKI | 2017 | Current Zoology2017，63，6： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 5 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 6 | Linear inertial piezoelectric motor with bimorph disc显示文摘 | DALIUS M PIOTR V | 2013 | Mechanical Systems and Signal Processing2013，36，： | 1 |
| 7 | Hemorheological changes dependent on the time from the onset of ischemic stroke 显示文摘 | Piotr K Anna M G | 2007 | Journal of the Neurological Sciences2007，258，： | 1 |
| 8 | Minimum spanning tree based one-class classifier显示文摘 | Piotr J Tax D M J Elzbieta P | 2009 | Neurocomputing2009，72，79： | 1 |
| 9 | Automated Diagnostics of Analog Systems Using Fuzzy Logic Approach显示文摘 | Piotr Bilski Jacek M W | 2007 | IEEE Transaction on Instrumentation and Measurement2007，56，6： | 1 |
| 10 | The effect of dexamedetomidine sedation on brachial plexus block in patients with end-stage renal disease显示文摘 | Katarzyna R Piotr K Hanna M | 2009 | Eur J Anaesthesiol2009，26，10： | 1 |
| 11 | Fast pyrolysis of sweet sorghum and sweet sorghum bagasse 显示文摘 | JAN P PIOTR M | 1998 | Journal of Analytical Pyrolysis1998，，46： | 1 |
| 12 | Effects of concentration on the performance of erbium-doped fiber amplifiers 显示文摘 | PIOTR M DUNG N JACEK C | 1997 | Journal of Lightzoave Technology1997，15，1： | 1 |
| 13 | The effect of dexamed- etomidine sedation on brachial plexus block in patients with end - stage renal disease 显示文摘 | KATARZYNA R PIOTR K HANNA M | 2009 | Eur J Anaesthesiol2009，26，10： | 1 |
| 14 | The effect of dexmedetomidine sedation on brachial plexus block in patients with endstage renal disease显示文摘 | Katarzyna R Piotr K Hanna M | | 0，，10： | 1 |
| 15 | The effect of dexmedeto- midine sedation on brachial plexus block in patients with end-stage renal disease 显示文摘 | Katarzyna R Piotr K Hanna M | 2009 | European Journal of Anaesthe- siology2009，26，10： | 1 |
| 16 | Effect of temperature on the physical, functional, and mechanical characteristics of hot-air-puffed amaranth seeds显示文摘 | Piotr Z Marek M Katarzyna M | 2006 | Journal of Food Engineering2006，76，： | 1 |
| 17 | The effect of dexmedetomidine sedation on braehial plexus block in patients with end - stage renal disease 显示文摘 | Katarzyna R Piotr K Hanna M | 2009 | European Journal of Anaesthesiology2009，26，10： | 1 |
| 18 | Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma显示文摘 | Gary Hudes M D Michael Carducci M D Piotr Tomczak M D | 2007 | N Engl J Med2007，22，356： | 1 |
| 19 | Isolation and quantitative determi- nation of ergosterol peroxide in various mushroom species 显示文摘 | Wojciech K Eliza M Piotr S | 2009 | Food chemistry2009，113，1： | 1 |
| 20 | The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease显示文摘 | Katarzyna R Piotr K Hanna M | 2009 | Eur J Anaesthesiol2009，26，10： | 1 |
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