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| 1 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 2 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 3 | Formation of epitaxial and polycrystalline films of the electron doped system La1-xCexMnO3 through pulsed laser deposition 显示文摘 | Mitra C Raychaudhuri P Dhar S K Nigam A K Pinto R | 2001 | Journal of Magnetism and Magnetic Materials2001，22，： | 1 |
| 4 | Sizing of MOS transistors for amplifier design显示文摘 | Pinto R L D Schneider M C Montoro C G | 2002 | IEEE International Symposium on Circuits and Systems2002，5，： | 1 |
| 5 | Cellular distributionof growth hormone-releasing hormone receptor in humanreproductive system and breast and prostate cancers显示文摘 | Gallego R Pintos E Garcia-Caballero T | 2005 | HistolHistopathoi2005，20，3： | 1 |
| 6 | Arterial bleeding in pelvic trau-ma !priorities in angiographic embolization显示文摘 | Niola R Pinto A Sparano A | 2012 | Curr Probl DiagnRadiol2012，41，3： | 1 |
| 7 | Cellular immune responses to HPV-I 8, -3 I, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles 显示文摘 | Pinto LA Viscidi R Harro CD | 2006 | Virology2006，353，2： | 1 |
| 8 | Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients 显示文摘 | Grassi R Romano S Pinto A | 2004 | Ear J Radiol2004，50，1： | 1 |
| 9 | Volume replacement with lactated Ringer's or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury显示文摘 | Pinto FC Capone-Neto A Prist R | | 0，，04： | 1 |
| 10 | CT evaluationof appendicitis and its complications:Imaging techniques and key diagnostic findings显示文摘 | Pinto Leite N Pereira JM Cunha R | 2005 | AJR Am J Roentgenol2005，184，2： | 1 |
| 11 | Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not dif- fer in symptom intensity or response to onabotulinum toxin A 显示文摘 | Pinto R Lopes T Costa D | 2014 | Urology2014，83，5： | 1 |
| 12 | Long-term resuits of percutaneous ethanol injection therapy for hcpatocellular carcinoma in cirrhosis: a European experience 显示文摘 | Lencioni R Pinto F Armillotta N | 1997 | Eur Radiol1997，7，： | 1 |
| 13 | 显示文摘 | Rao K S Naidu B S Hussain O M Pinto R | 2002 | J Mater Sci: Mater Electro2002，13，： | 1 |
| 14 | Geographical distribution of Tilland- sia lomas in the Atacama Desert, northern Chile 显示文摘 | Pinto R Barria I Maarquet P A | 2006 | Journal of Arid Environments2006，65，： | 1 |
| 15 | In-house method validation: Application in arsenic analysis显示文摘 | de Souza S V C Pinto C T Junqueira R G | 2007 | Food Composition and Analysis2007，20，34： | 1 |
| 16 | Skull base cephalometrie changes in cranial expansion by springs 显示文摘 | deFaria Valle Dornelles R Cardim VL de Campos Fonseca Pinto AC | 2011 | J CraniofacSurg2011，22，： | 1 |
| 17 | Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis显示文摘 | Pinto R Frias B Allen S | 2010 | Neuroscience2010，166，： | 1 |
| 18 | Subrrigationreduces water use,nitrogen loss and moss growth in a containernursery显示文摘 | Dumroese R K Pinto J R Jacobs D F | 2006 | Native plants2006，7，3： | 1 |
| 19 | Origins andfunctional impact of copy number variation in the hu-man genome显示文摘 | Conrad D F Pinto D Redon R | 2010 | NaZwr^2010，464，： | 1 |
| 20 | Origins and functional impact of copy number variation in the human genome显示文摘 | Conrad DF Pinto D Redon R | | 0，，： | 1 |
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