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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 3 | The p rog-nostic significance of membrane transport2associated multidrug resistance (MDR) proteins in leukenia 显示文摘 | Van der Heuvel-EibrinkM M Sonneveld P Pieters R | 2000 | Int J Clin Pharmacol Ther2000，38，3： | 1 |
| 4 | Mutation of Tyrosine Residues Involved in the Alkylation Half Reaction of Epoxide Hydrolase from Agrobacterium radiobacter AD1 Results in Improved Enantioselectivity显示文摘 | Spelberg J H K Pieters R J | 1999 | J Am Chem Soc1999，12，17： | 1 |
| 5 | In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia 显示文摘 | Kaspers GJ Veerman A J Pieters R | 1997 | Blood1997，90，7： | 1 |
| 6 | The N2myc paradox:N2myc overexpression in neurblastoma is associated wit h sensi2tivity as well as resistance to apoptosis显示文摘 | Nosel M M Pieters R Voute P A | 2003 | Cancer Lett2003，197，12： | 1 |
| 7 | Biological and therapeutic aspects of infant leukemia 显示文摘 | Biondi A Cimino G Pieters R | 2000 | Blood2000，96，： | 1 |
| 8 | Unrelated medi- cal costs in life-years gained 显示文摘 | DAVID R R PIETER H M B JOB A E | 2008 | Pharmacoeconomics2008，26，10： | 1 |
| 9 | Identification of tumor - related proteins by preteomic analysis of cerebrospinal fluid from patients with primary brain tumors 显示文摘 | Zheng PP Luider TM Pieters R | 2003 | Neurepathol Exp Neurol2003，62，8： | 1 |
| 10 | Eye fixations on advertisements and memory of brands:A model and findings显示文摘 | WedeI M Pieters R | | 0，，04： | 1 |
| 11 | Mutation of tyrosine residues involved in the alkylation half reaction of epoxide hydrolase from Agrobacterium radiobacter AD1 results in improved enantioselectivity显示文摘 | Rink R Spelberg J H L Pieters R J | | 0，，32： | 1 |
| 12 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 13 | Dynamic monolayer behavior of a photo - responsive azobenzene surfactant 显示文摘 | INSUN K JOHN F R PIETER S | 2000 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2000，171，： | 1 |
| 14 | Modeling of equiaxed microstructure formation in casting显示文摘 | Pieters R | 1987 | Phys Rev A1987，37，： | 1 |
| 15 | Sales Effects of Visual Attention tofeature ads: A Bayesian Mediation Analysis显示文摘 | Zhang J M Wedel R Pieters | 2009 | Journal of Mar-keting Research2009，46，5： | 1 |
| 16 | Towards targeted therapy for infant acute lymphoblastic leukaemia显示文摘 | Stam RW den Boer ML Pieters R | 2006 | Br J Haematol2006，132，5： | 1 |
| 17 | Murine models of drug hypersensitivity显示文摘 | Nierkens S Pieters R | 2005 | Curr Opin Allergy Clin Immunol2005，5，4： | 1 |
| 18 | prospective proof of concept study of the efficacy of tacrolimus ointment onuraemicpruritus (UP) in patients on chronic dialysis therapy显示文摘 | Dirk R Kuypers Kathleen Claes Pieter Eveneplel | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 19 | In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia 显示文摘 | STYCZYNSKI J PIETERS R HUISMANS D R | 2000 | Br J Haematol2000，110，： | 1 |
| 20 | Particle Erosion Resistance of Laser Nitrided Ti- 6A1 - 4V显示文摘 | Pieters R | 2001 | Surface Engineering2001，17，2： | 1 |
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