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| 1 | 普萘洛尔治疗婴幼儿血管瘤的分子机制显示文摘血管瘤是婴幼儿最常见的肿瘤,虽然85%。90%的血管瘤可自发消退,但仍有部分患者存在生命危险或功能障碍,需要积极治疗。先前的治疗方法包括激光、冷冻、激素、干扰素、环磷酰胺等,所有这些方法都有其严重副反应。口服普萘洛尔是治疗复杂血管瘤的最新方法,疗效确定且患者耐受性好。但普萘洛尔治疗血管瘤的机制知之甚少。该文总结普萘洛尔对血管内皮细胞、血管生成及细胞凋亡的作用。 | Storch CH Hoeger PH | 2010 | 中国口腔颌面外科杂志2010，8，3： | 149 |
| 2 | 植物生长建模与可视化——回顾与展望显示文摘回顾了植物生长的建模与可视化研究 .为了加深对不同模型的目的、内涵与局限性的理解 ,该文对植物生长模型进行了分类 .在植物生长机研究中 ,对目前常见的分形方法、随机过程、人工智能等建模方法的特点进行了比较分析 .分别介绍了植物仿真与可视化方面的研究进展及其相关技术 ,以及植物生长软件的发展状况 .最后 ,总结了该领域研究中存在的主要问题 。 | 胡包钢 赵星 严红平 de Reffye Ph Blaise F 熊范纶 王一鸣 | 2001 | 自动化学报2001，27，6： | 142 |
| 3 | 关于空腹血糖、空腹胰岛素乘积的倒数在流行病学研究中应用的补充说明显示文摘高胰岛素正糖钳夹技术可以测定活体的胰岛素敏感性,但它并不适用于大规模流行病学研究。流行病学研究需要简单的胰岛素抵抗测定法。本文补充报告在空腹血糖(FPG)(75~306mg/dl或4.2~17.1mmol/L)及空腹胰岛素(FIns)(9.7~120mU/L)范围很宽的Pima印第安人群中,正糖钳夹技术测定的胰岛素介导的葡萄糖代谢率(M)与涉及FPG、FIns的多种复合的胰岛素敏感指数的相关性:胰岛素作用指数(IAI)=1/(FPG×FIns)在非糖尿病人群及2型糖尿病人群都与M显著正相关(r>0.7,P=0.0001),而且这两者的相关性强于M与其他指数如FIns或FPG/FIns比值的相关性,也不弱于M与糖负荷后3~5个时间点的血糖、胰岛素曲线下面积乘积的相关性。IAI的五分变量分布情况表明有90.4%的IAI落在所预测的M值五分变量区域或与之相邻的一个五分变量区域之内。1/FPG×FIns虽相对简单但确实与机体的胰岛素敏感性密切相关,它可以做为胰岛素敏感指数在流行病学研究中应用。 | 李光伟 Bennett PH | 2005 | 中华糖尿病杂志(1006-6187)2005，13，4： | 43 |
| 4 | 糖尿病流行病学研究中应用OGTT资料评估胰岛β细胞功能的可能性——468例非糖尿病Pima印第安人葡萄糖钳研究资料分析显示文摘目的 探讨以口服葡萄糖耐量试验 (OGTT)的简单参数在糖尿病流行病研究中评估胰岛 β细胞功能的可能性。方法 美国Pima印第安人糖耐量正常者 332例、糖耐量低减者 1 36例参与本试验。各例均做静脉葡萄糖耐量试验 (IVGTT) ,OGTT及正葡萄糖钳试验。计算Homa IR ,Homa β ,第一时相胰岛素分泌量 (AIR) ,胰岛素曲线下面积 ,ΔI30 /ΔG30 ,胰岛素介导的葡萄糖代谢率 (M ,mg·kg- 1 ·min- 1 )。从基本病理生理学概念推导新 β细胞功能指数MBCI=(FINS×FPG) / (PG2h +PG1h- 2×FPG) (FINS :空腹胰岛素 ;FPG :空腹血糖 ;PG1h和PG2h分别为OGTT 1h和 2h的血糖 )。以线性回归分析正葡萄糖钳技术测定的胰岛素敏感性与不同的β细胞功能指数的组合对血糖水平的贡献 ,探讨以OGTT的简单参数评估β细胞功能的可能性。 结果 (1 )调整M后 ,IGT组AIR、ΔI30 /ΔG30 、Homa β和MBCI与OGTT 2h血糖水平的偏相关系数分别为 - 0 .30、- 0 .30、- 0 .2 9及 - 0 .37(P均 <0 .0 0 1 ) ,但在NGT组则分别为 - 0 .0 6(P >0 .0 5)、0 .0 1 (P >0 .0 5)、- 0 .30 (P <0 .0 0 1 )及 - 0 .43(P <0 .0 0 1 )。 (2 )以OGTT 2h血糖为因变量 ,分别以M +AIR ,M +ΔI30 /ΔG30 ,M +Homa β,M +MBCI为自变量做线性回归分析 ,显示M | 李光伟 Bennett PH | 2003 | 中华内分泌代谢杂志2003，19，1： | 45 |
| 5 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019，26，12： | 23 |
| 6 | WONCA研究论文摘要汇编——对乙酰氨基酚治疗脊椎疼痛和骨关节炎的疗效和安全性:对随机安慰剂对照试验的系统综述和荟萃分析显示文摘目的探讨对乙酰氨基酚(扑热息痛)治疗脊椎疼痛和骨关节炎(髋关节、膝关节)的有效性和安全性。设计系统综述和荟萃分析。数据来源Medline、荷兰医学文摘数据库(EMBase)、AMED、CINAHL、Web of Science、LILACS、国际药学文摘、Cochrane对照试验中心注册库,时间自建库至2014年12月。研究的纳入标准研究须为随机对照试验,比较扑热息痛和安慰剂治疗脊椎疼痛(颈痛或下腰痛)和骨关节炎(髋关节、膝关节)的疗效和安全性。数据的提取由2名独立的研究人员分别提取关于疼痛、失能和生活质量的数据。次要结果指标包括:不良反应、患者依从性和急救药物的使用。疼痛和失能评分转换为0(没有疼痛或失能)到100(疼痛加重和失能)的数值。采用随机效应模型计算加权均数差(WMD)或风险比(HR)以及95%可信区间(95%CI)。应用Cochrane协作工具对偏倚风险进行评估,采用GRADE方法对证据的质量进行评估,并对结论进行总结。结果共纳入12篇报道(13项随机试验)。对于下腰痛患者,扑热息痛在短期内减少疼痛强度〔WMD=-0.5,95%CI(-2.9,1.9)〕、失能〔WMD=0.4,95%CI(-1.7,2.5)〕或提高生活质量〔WMD=0.4,95%CI(-0.9,1.7)〕等方面均是无效的。对于髋关节炎或膝关节炎患者,扑热息痛在短期内减轻疼痛〔WMD=-3.7,95%CI(-5.5,1.9)〕、失能〔WMD=-2.9,95%CI(-4.9,0.9)﹞方面有显著作用,尽管在临床意义上不重要。报告任何不良反应〔HR=1.0,95%CI(0.9,1.1)〕、任何严重不良反应〔HR=1.2,95%CI(0.7,2.1)〕或因为不良事件退出研究〔HR=1.2,95%CI(0.9,1.5)〕的患者数量,在扑热息痛组和安慰剂组中类似。坚持治疗的患者数量〔HR=1.0,95%CI(0.9,1.1)〕和使用急救药物〔HR=0.7,95%CI(0.4,1.3)〕的患者数量,在两组之间也是相似的。扑热息痛组患者发生肝功能异常的概率是安慰剂组患者的4倍〔HR=3.8,95%CI(1.9,7.4)〕,但这种效应的临床意义是不确定的。结论扑热息痛在治疗腰痛方面是无效的,但可以对骨关节炎患者提供最小的短期利益。现有的临床实践指南推荐对下腰痛患者、髋关节或膝关节骨关节炎患者使用扑热息痛治疗,以上研究结果支持对这些推荐进行重新审议。 | Machado GC Maher CG Ferreira PH 本刊编辑部 | 2015 | 中国全科医学2015，18，15： | 17 |
| 7 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 8 | Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘 | Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 9 | 白炭黑用于降低轮胎滚动阻力的研究显示文摘轮胎材料的设计者在轮胎胎面中使用了沉淀法白炭黑和溶聚聚合物似乎成功地得到了低的滚动阻力和高的湿路面行驶性能。但滚动阻力仍需要进一步改善 ,而沉淀法白炭黑可能还是解决这个问题的要素之一。配合沉淀法白炭黑的胶料 ,尤其是配合高分散性白炭黑 ,可以改进轮胎的滚动阻力和许多轮胎部件的其它性能。我们认为它不但有助于满足轿车轮胎 ,而且也有助于满足其它种类轮胎新的低滚动阻力要求。 | Bomal Y Touzet S Barruel R Cochet Ph Dejean B 王军 | 2002 | 轮胎工业2002，22，6： | 12 |
| 10 | Evaluation of hepatic cystic lesions显示文摘Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. | Marten A Lantinga Tom JG Gevers Joost PH Drenth | 2013 | World Journal of Gastroenterology2013，19，23： | 12 |
| 11 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 12 | 中国人地关系评价的理论模型与实证(英文)显示文摘China’s coupled human-environment system(CHES) is assessed here via a systems schema that emphasizes the complex interactions of components and their attributes. In addition to the human and environment components, we identified two other components to evaluate the relationship. The four components are human activity intensity, resource carrying capacity, ecological constraints and system’s openness. Based on their interactions, we derived a cognitive schema for classifying the level of strain or stress of an area. The analysis draws on 11 indicators and 29 sub-indicators including remote sensing data and statistical data that are used to estimate the four components. The findings indicate that human activities are highly intense in a few geographical areas, particularly large urban systems and trade and investment zones on the eastern coastal areas. Nonetheless, these areas are also well-endowed in water resources and fertile soils although urban systems are increasingly stressed from negative pollution externalities. They are also open systems which allow them to bear a higher level of pressure and adjust accordingly. Desertification and soil erosion point to relatively fragile biophysical systems in the west and southwest, but human activities are still relatively less intense compared to their coastal counterparts. As a whole, only 14% of areas may be said to be relatively or highly strained. This however belies another one-third of areas that are currently unstable, and likely to become strained and thereby vulnerable in the near future. | 杨宇 李小云 董雯 POON PH Jessie 洪辉 何则 刘毅 | 2019 | Journal of Geographical Sciences2019，29，8： | 9 |
| 13 | 喷施乙烯利抑制甘蔗开花提高糖产量显示文摘 | Moor.,PH 欧仕益 | 1990 | 国外农学(甘蔗)1990，，2： | 7 |
| 14 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 15 | 云南腾冲地区含锡花岗岩及其与成矿关系显示文摘 | 毛景文 张士鲁 Ph Rossi. | 1987 | 岩石学报1987，，4： | 6 |
| 16 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 17 | Over-expression of a hydroxypyruvate reductase in Methylobacterium sp MB200 enhances glyoxylate accumulation显示文摘 | Shen, PH Wu, B | 2007 | 中国生物学文摘2007，21，10： | 6 |
| 18 | 活性氧化铝除氟研究显示文摘针对目前活性氧化铝饮水除氟中存在的问题,进行了生产性试验研究,通过采用原水投加CO_2气体降低pH值、小颗粒活性氧化铝、大流量短历时的NaOH循环再生法等新技术,提高了活性氧化铝的吸附容量和处理水的能力,克服滤料板结和假疲劳,除氟效果稳定可靠,水质好,再生时间短,用药省,降低了基建投资和运转费用。 | North China Municipal Engineering Design Institute A full-scale plant was set up for studying the existing problems on the fluoride removal from drinking water by activated alumina. Some new methods was adopted,such as the addition of CO2to reduce water pH value,the use of small-sized activated alumina,and the employment of a cyclic regeneration at large flow rate with NaOH as regenerant,which result in the improvement of adsorption capacity of activated alumina and treatment capacity, the elimination of the hardening of filtration materials and false fatigue,stable and reliable effectiveness,good quality in water,short regeneration time,small consumption of regenerant. And then the capital and openational costs were reduced. | 1989 | 中国给水排水1989，5，3： | 5 |
| 19 | 抗艾滋病病毒疫苗研究现状(摘要)显示文摘发现艾滋病病毒(HIV)已有近30年,尽管其他病毒性疾病(如脊髓灰质炎、麻疹、腮腺炎、风疹、乙型病毒性肝炎和流行性感冒等)的疫苗研究都取得了成功,研制有效的抗HIV疫苗却一直未能有所突破。和其他感染性病毒相比,HIV具有一些独特的特性,使其疫苗研发面临更大的挑战。HIV主要感染免疫系统,尤其是特异性地攻击CD4+T淋巴细胞,具有逃避免疫清除的一些机制,同时还可以通过整合到宿主的染色体中建立1种潜伏的贮库。 | Yong Gao M D and Ph D Professor | 2011 | 抗感染药学2011，8，1： | 5 |
| 20 | 高分散性沉淀法白炭黑在轮胎中的应用研究显示文摘利用沉淀法白炭黑与溶液聚合物和偶联剂配合 ,配方设计人员在成功地降低了轮胎胎面滚动阻力的同时提高了湿路面牵引性。用高分散性白炭黑替代普通白炭黑能改善胶料的加工性能和提高耐磨性能。仍有必要进一步降低滚动阻力 ,而使用沉淀法白炭黑是方法之一。含沉淀法白炭黑尤其是高分散性白炭黑的胶料降低了轮胎的滚动阻力和提高了轮胎多个部位的其它性能。我们认为 ,使用沉淀法白炭黑不仅有助于轿车轮胎 ,而且有助于其它轮胎产品达到新的低滚动阻力要求。 | Ph Cochet D.Petit L.Barriquand B.Dejean Y.Bomal 黄家明 | 2001 | 轮胎工业2001，21，8： | 5 |
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