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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | 持续性胸痛预示无闭塞性冠状动脉疾病女性中的心血管事件:NIH-NHLBI发起的女性缺血综合征评价(WISE)研究的结果显示文摘Aims: Women with chest pain but without obstructive coronary artery disease(CAD) are considered at low risk for cardiovascular(CV) events, but half continue to experience debilitating chest pain over many years. This study compared CV outcomes in women with persistent chest pain(PChP) vs. those without PChP. Methods and results: We studied 673 Women’s Ischaemia Syndrome Evaluation(WISE) participants with chest pain undergoing coronary angiography for suspected myocardial ischaemia and at least 1 year of follow-up. PChP was defined as self-reported continuing chest pain after 1 year. Events occurring after that year were recorded for a median of 5.2 years. We compared CV event rates for women with and without PChP in subgroups with and without obstructive CAD. The median age was 58 years, 20%were racial minorities, 45%had PChP, 39%had obstructive CAD. Among women without CAD, those with PChP had more than twice the rate of composite CV events(P=0.03), that included non-fatal myocardial infarctions(P=0.11), strokes(P=0.03), congestive heart failure(P=0.38), and CV deaths(P=0.73), compared with those without PChP. In women with CAD, there was no difference in composite CV events in those with and without PChP(P=0.72). Conclusion: Among women undergoing coronary angiography for suspected myocardial ischaemia, PChP in women with no obstructive CAD predicted adverse CV outcomes. Such women might benefit from additional evaluation and aggressive risk factor modification therapy. | Johnson B.D. Shaw L.J. Pepine C.J. 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 8 |
| 3 | 罹患高血压的非洲裔美国人和美国白人的肠道微生物群及血清代谢物差异显示文摘非洲裔美国人高血压患病率、严重程度和高血压治疗抵抗均高于美国白人。肠道微生物菌群及其代谢产物的不同可能是造成这种现象的原因。为此,Walejko等收集研究人群的粪便和血液样本分别用于肠道微生物群的全基因组测序(whole genome sequencing,WGS)和血清整体非靶向代谢组学研究,对上述假设进行了验证。 | Walejko JM Kim S Goel R Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 7 |
| 4 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 5 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 6 | 青藏高原雪深变化主导其变暖海拔依赖性的演化模态显示文摘气候变暖海拔依赖性指海拔越高,变暖越快的现象,其可能会加速青藏高原高海拔区积雪、冰川等的消融,从而严重影响周边地区水资源的可持续供给.目前对青藏高原变暖的海拔依赖性是否存在及其驱动过程缺乏系统性认识,部分研究存在争议.利用1973~2018年期间30年滑动窗口所得17个时期的133个台站气温观测资料,本研究揭示了青藏高原变暖的海拔依赖性会随时间推移发生变化:在早期区域变暖较弱时,不同海拔雪深变化有限,不存在变暖的海拔依赖性;但随着时间推移,区域变暖加剧,高海拔雪深显著减少,导致变暖的海拔依赖性开始形成并越来越明显.这表明区域变暖加剧可通过减少高海拔区雪深,控制着青藏高原变暖海拔依赖性的演化模态.这解释了前人针对不同时期研究所得结果的分歧,并预示未来更暖背景下青藏高原变暖的海拔依赖性可能会加强.这一结论对评估青藏高原固态水资源长期可持续性具有重要意义. | 郭东林 Nick Pepin 阳坤 孙建奇 李多 | 2021 | Science Bulletin2021，66，11： | 4 |
| 7 | A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach显示文摘This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. | Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet | 2020 | Chinese Medical Journal2020，，13： | 3 |
| 8 | 母体卡托普利治疗可持续改善肠-脑轴并减轻雄性后代的高血压显示文摘母胎相互作用在后代的远期健康及跨代高血压的发生中发挥作用。然而,目前对于母体对后代肠道及肠道微生物环境的影响在后代高血压控制中的作用仍知之甚少。此研究旨在检验母体对后代肠-脑轴产生影响,继而影响后代高血压发生这一假设。本研究选用卡托普利进行实验,卡托普利是一种具有抗菌特性的血管紧张素转换酶抑制剂。在整个怀孕和哺乳期间,对怀孕的自发性高血压母鼠和正常血压的母鼠(WKY组)给予卡托普利水[100 mg/(kg·d)]或无菌水。 | 周卫(译) 叶鹏(校) Li H Yang T Richards EM Pepine CJ Raizada MK | 2020 | 中华高血压杂志2020，28，5： | 3 |
| 9 | Effects of cadmium on the performance and microbiology of laboratory-scale lagoons treating domestic sewage显示文摘 | BONNET J L BOHATIER J PEPIN D | 1999 | Chemosphere1999，38，3： | 1 |
| 10 | Assessment of women with suspected myocardial ischemia: review of findings of the Women's Ischemia Syndrome Evaluation (WISE) Study 显示文摘 | Lewis JF McGorray SP Pepine CJ | 2002 | Curr Womeus Health Rep2002，2，2： | 1 |
| 11 | 14 nights of intermittent hypoxiaelevate daytime blood pressure and sympathetic activity in healthy hu-mans显示文摘 | Tamisier R Pepin JL Remy al | 2011 | Eur Respir J2011，37，1： | 1 |
| 12 | Inflammation in atheroscle- rosis:some thoughts about acute coronary syndromes 显示文摘 | Lucas AR Korol R Pepine CJ | 2006 | Circulation2006，113，17： | 1 |
| 13 | An intravascular ultrasound analysis in women experiencing chest pain in the absence of obstructive coronary artery disease: a substudy from the National Heart,Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE) 显示文摘 | KHUDDUS M A PEPINE C J HANDBERG E M | 2010 | J Interv Cardiol2010，23，6： | 1 |
| 14 | Insights from theNHLB1-sponsored women’s ischemia syndrome evaluation (WISE)study: part1: gender differences in traditional and novel risk factors,symptom evaluation, and gender-optimized diagnostic strategies显示文摘 | Shaw LJ Bairey Merz CN Pepine CJ | 2006 | JAm Coll Cardial2006，47，3： | 1 |
| 15 | Vancomycin for the treatment of clostridium difficile Infection: for whom is this expensive bullet really magic显示文摘 | Pepin J | 2008 | Clin Infect Dis2008，46，10： | 1 |
| 16 | Increasing risk of relapse after treatment of Clostridium dif{icile colitis in Quebec, Canada显示文摘 | Pepin J Alary M E Valiquette L | 2005 | Clin Infect Dis2005，40，15： | 1 |
| 17 | Temperature trends at high elevations: patterns across the globe 显示文摘 | Pepin N C Lundquist J D | 2008 | Geophysical Research Letters2008，35，14： | 1 |
| 18 | Metabolic syndrome and cardiovascular disease: challenges and opportunities 显示文摘 | Cooper - dehoff RM Pepine CJ | 2007 | Clin Cardiol2007，30，12： | 1 |
| 19 | Carotid -artery intima and media thickness as a risk factor for myocardial infarction and stroke 显示文摘 | Nichols WW Pepine CJ O'Rourke MF | 1999 | New Eng J Med1999，340，22： | 1 |
| 20 | Cyclooxygenase-2 inhibition and cardiovascular events显示文摘 | Pitt B Pepine C Willerson JT | | 0，，02： | 1 |
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